{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=ALS&page=11&q=motor+neuron+disease", "query": { "q": "motor neuron disease", "condition": "ALS", "page": 11 }, "page_size": 10 }, "pagination": { "page": 11, "page_size": 10, "total_count": 442, "total_pages": 45, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=ALS&page=12&q=motor+neuron+disease&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=ALS&page=10&q=motor+neuron+disease&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-14T23:24:46.446Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06704347", "title": "Safety Study of XT-150 in Participants With ALS", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Amyotrophic Lateral Sclerosis (ALS)" ], "interventions": [ { "name": "XT-150", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Xalud Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 8, "start_date": "2027-03", "completion_date": "2028-06", "has_results": false, "last_update_posted_date": "2026-07-29", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 4, "location_summary": "Phoenix, Arizona • Baltimore, Maryland • Boston, Massachusetts + 1 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Detroit", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT06704347" }, { "nct_id": "NCT05035823", "title": "COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Neurologic Disorder", "Paralysis", "Paralysis; Stroke", "Amyotrophic Lateral Sclerosis", "Muscular Dystrophies", "Spinal Cord Injuries", "Stroke, Lacunar", "Stroke Brainstem", "Cervical Spinal Cord Injury", "Spinal Muscular Atrophy", "Tetraplegic; Paralysis", "Quadriplegia/Tetraplegia" ], "interventions": [ { "name": "Motor Neuroprosthesis (MNP)", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Synchron Medical, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "21 Years to 75 Years" }, "enrollment_count": 6, "start_date": "2022-04-27", "completion_date": "2028-09", "has_results": false, "last_update_posted_date": "2026-09-08", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 3, "location_summary": "Buffalo, New York • New York, New York • Pittsburgh, Pennsylvania", "locations": [ { "city": "Buffalo", "state": "New York" }, { "city": "New York", "state": "New York" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT05035823" }, { "nct_id": "NCT06392126", "title": "Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALS", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Amyotrophic Lateral Sclerosis" ], "interventions": [ { "name": "nL-CHCHD-001", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "n-Lorem Foundation", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "48 Years", "maximum_age": null, "sex": "MALE", "summary": "48 Years and older · Male only" }, "enrollment_count": 1, "start_date": "2024-04-16", "completion_date": "2027-04", "has_results": false, "last_update_posted_date": "2026-07-13", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 1, "location_summary": "Jacksonville, Florida", "locations": [ { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06392126" }, { "nct_id": "NCT05276349", "title": "Home-based Remote Digital Monitoring to Assess ALS Progression (Track ALS)", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "ALS (Amyotrophic Lateral Sclerosis)" ], "interventions": [], "intervention_types": [], "sponsor": "St. Joseph's Hospital and Medical Center, Phoenix", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 80, "start_date": "2022-02-21", "completion_date": "2024-08-28", "has_results": false, "last_update_posted_date": "2024-11-12", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 2, "location_summary": "Phoenix, Arizona • Atlanta, Georgia", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT05276349" }, { "nct_id": "NCT00537641", "title": "Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Amyotrophic Lateral Sclerosis", "Motor Neuron Disease" ], "interventions": [], "intervention_types": [], "sponsor": "Columbia University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 25, "start_date": "2007-05", "completion_date": "2011-06", "has_results": false, "last_update_posted_date": "2015-07-07", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00537641" }, { "nct_id": "NCT04615923", "title": "HEALEY ALS Platform Trial - Regimen D Pridopidine", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Amyotrophic Lateral Sclerosis" ], "interventions": [ { "name": "Pridopidine", "type": "DRUG" }, { "name": "Matching Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merit E. Cudkowicz, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 163, "start_date": "2020-12-18", "completion_date": "2022-07-14", "has_results": true, "last_update_posted_date": "2023-08-23", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04615923" }, { "nct_id": "NCT02936635", "title": "A Study for Patients Who Completed VITALITY-ALS (CY 4031)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Amyotrophic Lateral Sclerosis (ALS)" ], "interventions": [ { "name": "tirasemtiv", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cytokinetics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 280, "start_date": "2016-10-17", "completion_date": "2018-10-26", "has_results": true, "last_update_posted_date": "2021-06-15", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 41, "location_summary": "Phoenix, Arizona • Los Angeles, California • Orange, California + 36 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02936635" }, { "nct_id": "NCT01785550", "title": "Neuromuscular Ultrasound in ALS", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "ALS" ], "interventions": [ { "name": "Ultrasound of nerve and muscle", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2013-02", "completion_date": "2015-03", "has_results": false, "last_update_posted_date": "2015-03-11", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT01785550" }, { "nct_id": "NCT07298486", "title": "Impact of Robotic Glove Use on Quality of Life, Grip Strength and Fine Motor Control in ALS", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Amyotrophic Lateral Sclerosis (ALS)" ], "interventions": [ { "name": "Robotic Glove Use", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Nova Southeastern University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 5, "start_date": "2026-02-09", "completion_date": "2026-07-30", "has_results": false, "last_update_posted_date": "2026-02-25", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 1, "location_summary": "Davie, Florida", "locations": [ { "city": "Davie", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07298486" }, { "nct_id": "NCT04031469", "title": "A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease", "overall_status": "SUSPENDED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Gut Microbiome", "Gastrointestinal Microbiome", "Autism", "Autism Spectrum Disorder", "Autism Spectrum Disorder High-Functioning", "Alzheimer Disease", "Alzheimer Dementia (AD)", "Alzheimer Dementia", "Alzheimer Disease (AD)", "Crohn", "Crohn Colitis", "Crohn Disease (CD)", "Crohn Disease Colon", "Myalgic Encephalomyelitis", "ME/CFS", "Myalgic Encephalomyelitis (ME)", "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", "Psoriasis", "Psoriasis Annularis", "Psoriasis Chronic", "Chronic Urinary Tract Infection", "Ulcerative Colitis (Disorder)", "Ulcerative Colitis (UC)", "Ulcerative Colitis Acute", "Ulcerative Colitis Chronic", "Multiple Sclerosis", "Multiple Sclerosis (MS) - Relapsing-remitting", "Multiple Sclerosis (MS) Primary Progressive", "Constipation Chronic Idiopathic", "Constipation", "Celiac", "Celiac Disease", "Celiac Sprue", "Lyme Arthritis", "Lyme Borreliosis, Nervous System", "Lyme Disease, Chronic", "Cholesterol", "Cholesterol Level, High", "Cancer", "Colon Cancer", "Amyotrophic Lateral Sclerosis (ALS)", "Amyotrophic Lateral Sclerosis", "Rheumatoid Arthritis (RA)", "Rheumatoid Arthritis - Rheumatism", "Chronic Fatigue Syndrome (CFS)", "PARKINSON DISEASE (Disorder)", "Parkinson Disease", "Parkinson Disease (PD)", "Depression", "Major Depressive Disorder (MDD)", "Depression Disorder", "Depression in Adults", "Anxiety", "Anxiety Disorder Generalized", "Obsessive Compulsive Disorder (OCD)", "Obsessive Compulsive Disorder OCD", "Obsessive - Compulsive Disorder", "Bipolar", "Bipolar 1 Disorder", "Bipolar Disorder (BD)", "Bipolar Disorder I and II", "Bipolar and Related Disorders", "Migraine", "Migraine Disorder", "Diabetes (DM)", "Diabetes", "Lupus", "Lupus Erythematosus", "Epidermolysis Bullosa (EB)", "Mesothelioma", "Mesothelioma Malignant", "IBS (Irritable Bowel Syndrome)", "Irritable Bowel", "IBS - Irritable Bowel Syndrome", "Irritable Bowel Syndrome (IBS)", "Eczema", "Eczema Atopic Dermatitis", "Acne", "Myasthaenia Gravis", "Gout" ], "interventions": [ { "name": "There is no intervention in this study", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "ProgenaBiome", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 1000, "start_date": "2019-07-11", "completion_date": "2030-12-10", "has_results": false, "last_update_posted_date": "2026-09-21", "last_synced_at": "2026-10-14T23:24:46.446Z", "location_count": 1, "location_summary": "Ventura, California", "locations": [ { "city": "Ventura", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04031469" } ] }