{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acetaminophen+Toxicity",
    "query": {
      "condition": "Acetaminophen Toxicity"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 16,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acetaminophen+Toxicity&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T17:36:33.372Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05517668",
      "title": "Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Acetaminophen",
        "Drug Overdose",
        "Acetaminophen Overdose",
        "Acetaminophen Poisoning",
        "Drug-induced Liver Injury",
        "Liver Failure",
        "Liver Toxicity"
      ],
      "interventions": [
        {
          "name": "Intravenous infusion of N-acetylcysteine",
          "type": "DRUG"
        },
        {
          "name": "Intravenous infusion of Fomepizole (4-MP)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Richard Dart, MD, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "10 Years to 99 Years"
      },
      "enrollment_count": 29,
      "start_date": "2022-09-12",
      "completion_date": "2025-11-08",
      "has_results": false,
      "last_update_posted_date": "2025-11-25",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 1,
      "location_summary": "Denver, Colorado",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05517668"
    },
    {
      "nct_id": "NCT00166608",
      "title": "Cytokines Polymorphisms and Acetaminophen Toxicity",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Drug Toxicity"
      ],
      "interventions": [
        {
          "name": "Blood sampling",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Arkansas Children's Hospital Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 111,
      "start_date": "2002-12",
      "completion_date": "2007-09",
      "has_results": false,
      "last_update_posted_date": "2012-04-12",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 7,
      "location_summary": "Little Rock, Arkansas • Louisville, Kentucky • Detroit, Michigan + 4 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "Kansas City",
          "state": "Missouri"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00166608"
    },
    {
      "nct_id": "NCT00743093",
      "title": "Aminotransferase Trends During Prolonged Acetaminophen Dosing",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Drug Toxicity",
        "Healthy"
      ],
      "interventions": [
        {
          "name": "acetaminophen",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Denver Health and Hospital Authority",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 398,
      "start_date": "2008-08",
      "completion_date": "2011-08",
      "has_results": true,
      "last_update_posted_date": "2013-09-18",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 2,
      "location_summary": "Aurora, Colorado • Denver, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00743093"
    },
    {
      "nct_id": "NCT01246713",
      "title": "Effect on Acetaminophen Metabolism by Liquid Formulations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acetaminophen Metabolism",
        "Acetaminophen Poisoning",
        "Drug Metabolism by Excipients"
      ],
      "interventions": [
        {
          "name": "Acetaminophen liquid formulation",
          "type": "DRUG"
        },
        {
          "name": "Acetaminophen solid formulation",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 15,
      "start_date": "2010-12",
      "completion_date": "2012-07",
      "has_results": true,
      "last_update_posted_date": "2017-05-08",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01246713"
    },
    {
      "nct_id": "NCT02322879",
      "title": "Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Acetaminophen Toxicity"
      ],
      "interventions": [
        {
          "name": "First Treatment Period",
          "type": "DRUG"
        },
        {
          "name": "Washout",
          "type": "OTHER"
        },
        {
          "name": "Second Treatment Period",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "20 Years to 40 Years"
      },
      "enrollment_count": 21,
      "start_date": "2013-05",
      "completion_date": "2016-12",
      "has_results": true,
      "last_update_posted_date": "2017-09-01",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02322879"
    },
    {
      "nct_id": "NCT01328808",
      "title": "Metabolism and Toxicity of Acetaminophen",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Pain"
      ],
      "interventions": [
        {
          "name": "Acetaminophen/APAP",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "John van den Anker",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Weeks",
        "maximum_age": "37 Weeks",
        "sex": "ALL",
        "summary": "22 Weeks to 37 Weeks"
      },
      "enrollment_count": 31,
      "start_date": "2011-10",
      "completion_date": "2022-12",
      "has_results": false,
      "last_update_posted_date": "2022-03-02",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 2,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01328808"
    },
    {
      "nct_id": "NCT02786836",
      "title": "13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Acute Liver Failure"
      ],
      "interventions": [
        {
          "name": "13C-Methacetin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Texas Southwestern Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 76,
      "start_date": "2016-06-10",
      "completion_date": "2019-09-18",
      "has_results": true,
      "last_update_posted_date": "2020-12-22",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 11,
      "location_summary": "Birmingham, Alabama • San Francisco, California • New Haven, Connecticut + 8 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02786836"
    },
    {
      "nct_id": "NCT00725179",
      "title": "Treatment of Acetaminophen Toxicity With N-acetylcysteine",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acetaminophen Toxicity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Akron Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 130,
      "start_date": "2008-08",
      "completion_date": "2008-10",
      "has_results": false,
      "last_update_posted_date": "2011-09-09",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 1,
      "location_summary": "Akron, Ohio",
      "locations": [
        {
          "city": "Akron",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00725179"
    },
    {
      "nct_id": "NCT06214468",
      "title": "Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicity",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Drug Toxicity"
      ],
      "interventions": [
        {
          "name": "Acetaminophen and Nicotinamide Riboside",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Acetaminophen",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT",
        "DRUG"
      ],
      "sponsor": "University of South Alabama",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 26,
      "start_date": "2024-01-15",
      "completion_date": "2025-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-06",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 1,
      "location_summary": "Mobile, Alabama",
      "locations": [
        {
          "city": "Mobile",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06214468"
    },
    {
      "nct_id": "NCT01575847",
      "title": "Adduct Dipstick for Diagnosis of Acetaminophen Toxicity",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acetaminophen Toxicity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Arkansas Children's Hospital Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 120,
      "start_date": "2011-08",
      "completion_date": "2016-09",
      "has_results": false,
      "last_update_posted_date": "2017-01-04",
      "last_synced_at": "2026-06-10T17:36:33.372Z",
      "location_count": 1,
      "location_summary": "Little Rock, Arkansas",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01575847"
    }
  ]
}