{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acidosis%2C+Lactic", "query": { "condition": "Acidosis, Lactic" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 25, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acidosis%2C+Lactic&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-07-22T14:53:54.882Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00031161", "title": "Prevention of Dichloroacetate Toxicity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Acidosis, Lactic", "Chronic Disease" ], "interventions": [ { "name": "Nitisinone (NTBC)", "type": "DRUG" }, { "name": "Dichloroacetate", "type": "DRUG" }, { "name": "Low-tyrosin diet", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Months", "maximum_age": "21 Years", "sex": "ALL", "summary": "3 Months to 21 Years" }, "enrollment_count": 30, "start_date": "2001-09", "completion_date": "2005-09", "has_results": false, "last_update_posted_date": "2015-03-25", "last_synced_at": "2026-07-22T14:53:54.882Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00031161" }, { "nct_id": "NCT00739089", "title": "Presep and Vascath Interaction Study", "overall_status": "WITHDRAWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hemodynamics", "Renal Dialysis", "Sepsis", "Shock" ], "interventions": [], "intervention_types": [], "sponsor": "Wake Forest University Health Sciences", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2008-08", "completion_date": "2009-12", "has_results": false, "last_update_posted_date": "2017-11-08", "last_synced_at": "2026-07-22T14:53:54.882Z", "location_count": 1, "location_summary": "Winston-Salem, North Carolina", "locations": [ { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00739089" }, { "nct_id": "NCT01797276", "title": "Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access", "overall_status": "NO_LONGER_AVAILABLE", "study_type": "EXPANDED_ACCESS", "phases": [], "conditions": [ "Mitochondrial Enzyme Deficiencies" ], "interventions": [ { "name": "Dichloroacetate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2017-08-08", "last_synced_at": "2026-07-22T14:53:54.882Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01797276" }, { "nct_id": "NCT00638040", "title": "The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression", "overall_status": "WITHDRAWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hypoxia", "Lactic Acidosis" ], "interventions": [], "intervention_types": [], "sponsor": "Duke University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "18 Years to 50 Years · Female only" }, "enrollment_count": 0, "start_date": "2009-09", "completion_date": "2012-09", "has_results": false, "last_update_posted_date": "2014-07-11", "last_synced_at": "2026-07-22T14:53:54.882Z", "location_count": 1, "location_summary": "Durham, North Carolina", "locations": [ { "city": "Durham", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00638040" }, { "nct_id": "NCT06402123", "title": "A Phase 2b Study of Zagociguat in Patients With MELAS", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)" ], "interventions": [ { "name": "zagociguat 15mg", "type": "DRUG" }, { "name": "zagociguat 30mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tisento Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 43, "start_date": "2024-09-10", "completion_date": "2026-06-29", "has_results": false, "last_update_posted_date": "2026-07-07", "last_synced_at": "2026-07-22T14:53:54.882Z", "location_count": 10, "location_summary": "La Jolla, California • Aurora, Colorado • Atlanta, Georgia + 5 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT06402123" }, { "nct_id": "NCT02073747", "title": "The Various Effects of Gaseous Albuterol on Serum Lactate", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Asthma" ], "interventions": [ { "name": "Normal Saline", "type": "DRUG" }, { "name": "Albuterol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University Medical Center of Southern Nevada", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 28, "start_date": "2015-04", "completion_date": "2015-08", "has_results": true, "last_update_posted_date": "2017-08-14", "last_synced_at": "2026-07-22T14:53:54.882Z", "location_count": 1, "location_summary": "Las Vegas, Nevada", "locations": [ { "city": "Las Vegas", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT02073747" }, { "nct_id": "NCT02482597", "title": "Whole Body Periodic Acceleration on Blood Lactate and Recovery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Acidosis, Lactic" ], "interventions": [ { "name": "Whole Body Periodic Acceleration", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "New York Institute of Technology", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "35 Years", "sex": "ALL", "summary": "18 Years to 35 Years" }, "enrollment_count": 32, "start_date": "2015-06", "completion_date": "2017-06-01", "has_results": false, "last_update_posted_date": "2018-03-29", "last_synced_at": "2026-07-22T14:53:54.882Z", "location_count": 1, "location_summary": "Old Westbury, New York", "locations": [ { "city": "Old Westbury", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02482597" }, { "nct_id": "NCT03122678", "title": "Thiamine Supplementation in Patients With Septic Shock", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Septic Shock", "Shock, Septic", "Lactic Acidosis", "Thiamine Deficiency" ], "interventions": [ { "name": "Thiamine", "type": "DRUG" }, { "name": "Placebos", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2016-11-05", "completion_date": "2019-03-14", "has_results": false, "last_update_posted_date": "2019-03-15", "last_synced_at": "2026-07-22T14:53:54.882Z", "location_count": 1, "location_summary": "Weston, Florida", "locations": [ { "city": "Weston", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03122678" }, { "nct_id": "NCT06451757", "title": "KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Mitochondrial Diseases", "Maternally Inherited Diabetes and Deafness (MIDD)", "Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)", "Mitochondrial DNA tRNALeu(UUR) m.3243A