{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Appendicitis",
    "query": {
      "condition": "Acute Appendicitis"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 78,
    "total_pages": 8,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Appendicitis&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:18:52.916Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00414375",
      "title": "Early Versus Delayed Operation for Perforated Appendicitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Appendiceal Abscess"
      ],
      "interventions": [
        {
          "name": "Operation on Admission",
          "type": "PROCEDURE"
        },
        {
          "name": "Drainage and Interval Appendectomy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Children's Mercy Hospital Kansas City",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "Up to 18 Years"
      },
      "enrollment_count": 30,
      "start_date": "2006-12",
      "completion_date": "2009-03",
      "has_results": false,
      "last_update_posted_date": "2009-03-03",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 1,
      "location_summary": "Kansas City, Missouri",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00414375"
    },
    {
      "nct_id": "NCT04200729",
      "title": "Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Acute, Perforated Appendicitis"
      ],
      "interventions": [
        {
          "name": "Irrigation with PVI",
          "type": "DRUG"
        },
        {
          "name": "Usual care",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Years to 17 Years"
      },
      "enrollment_count": 1750,
      "start_date": "2027-03-01",
      "completion_date": "2030-03-01",
      "has_results": false,
      "last_update_posted_date": "2025-02-10",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04200729"
    },
    {
      "nct_id": "NCT04253899",
      "title": "The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Perforated Appendicitis"
      ],
      "interventions": [
        {
          "name": "Appendectomy",
          "type": "PROCEDURE"
        },
        {
          "name": "Observation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "OTHER"
      ],
      "sponsor": "Marshall University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 100,
      "start_date": "2020-02-20",
      "completion_date": "2023-11",
      "has_results": false,
      "last_update_posted_date": "2023-04-04",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 1,
      "location_summary": "Huntington, West Virginia",
      "locations": [
        {
          "city": "Huntington",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04253899"
    },
    {
      "nct_id": "NCT02784704",
      "title": "Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Complicated Intra-abdominal Infections",
        "Complicated Appendicitis"
      ],
      "interventions": [
        {
          "name": "Eravacycline",
          "type": "DRUG"
        },
        {
          "name": "Meropenem",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tetraphase Pharmaceuticals, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2016-10-13",
      "completion_date": "2017-05-19",
      "has_results": true,
      "last_update_posted_date": "2022-01-06",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 6,
      "location_summary": "Los Angeles, California • Indianapolis, Indiana • Las Vegas, Nevada + 3 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "Somers Point",
          "state": "New Jersey"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02784704"
    },
    {
      "nct_id": "NCT05488080",
      "title": "PAINED: Project Addressing INequities in the Emergency Department",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pain",
        "Appendicitis",
        "Bias, Racial",
        "Fractures, Bone"
      ],
      "interventions": [
        {
          "name": "Department-level audit and feedback and electronic health record-embedded clinical decision support",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Children's National Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "0 Years and older"
      },
      "enrollment_count": 22032,
      "start_date": "2023-02-27",
      "completion_date": "2026-08-23",
      "has_results": false,
      "last_update_posted_date": "2025-07-17",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05488080"
    },
    {
      "nct_id": "NCT01734837",
      "title": "TICAP - Titanium Clips for Appendiceal Stump Closure",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Appendicitis"
      ],
      "interventions": [
        {
          "name": "DS-Ligature Clip",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Aesculap AG",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 390,
      "start_date": "2011-10",
      "completion_date": "2013-08",
      "has_results": false,
      "last_update_posted_date": "2015-09-09",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 2,
      "location_summary": "Marina del Rey, California • Bethlehem, Pennsylvania",
      "locations": [
        {
          "city": "Marina del Rey",
          "state": "California"
        },
        {
          "city": "Bethlehem",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01734837"
    },
    {
      "nct_id": "NCT04168866",
      "title": "Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Appendicitis"
      ],
      "interventions": [
        {
          "name": "Operative management",
          "type": "PROCEDURE"
        },
        {
          "name": "Drainage or antibiotics",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 180,
      "start_date": "2020-03-11",
      "completion_date": "2029-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-08-29",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04168866"
    },
    {
      "nct_id": "NCT00323453",
      "title": "Wound Infection Alexis Wound Retractor",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Appendicitis"
      ],
      "interventions": [
        {
          "name": "Open appendectomy using Alexis Wound Retractor followed by standardized wound closure",
          "type": "DEVICE"
        },
        {
          "name": "Open appendectomy with standardized wound closure",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "Santa Barbara Cottage Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 109,
      "start_date": "2006-03",
      "completion_date": "2008-06",
      "has_results": true,
      "last_update_posted_date": "2018-11-23",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 1,
      "location_summary": "Santa Barbara, California",
      "locations": [
        {
          "city": "Santa Barbara",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00323453"
    },
    {
      "nct_id": "NCT01192620",
      "title": "Pediatric Appendicitis Pathway Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Appendicitis"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "3 Years to 18 Years"
      },
      "enrollment_count": 178,
      "start_date": "2010-10",
      "completion_date": "2011-08-31",
      "has_results": false,
      "last_update_posted_date": "2019-04-10",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01192620"
    },
    {
      "nct_id": "NCT02991937",
      "title": "Comparison of Medical and Surgical Treatment of Uncomplicated Acute Appendicitis in Children",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Appendicitis"
      ],
      "interventions": [
        {
          "name": "Piperacillin/Tazobactam",
          "type": "DRUG"
        },
        {
          "name": "Surgical Treatment",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "NYU Langone Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "6 Years to 17 Years"
      },
      "enrollment_count": 39,
      "start_date": "2016-12",
      "completion_date": "2020-12-01",
      "has_results": true,
      "last_update_posted_date": "2022-01-21",
      "last_synced_at": "2026-05-22T09:18:52.916Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02991937"
    }
  ]
}