{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Brain+Injury",
    "query": {
      "condition": "Acute Brain Injury"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 135,
    "total_pages": 14,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Brain+Injury&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-21T23:18:49.177Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04677829",
      "title": "Safety and Tolerability of PNT001 in Patients With Acute Traumatic Brain Injury (TBI)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "PNT001",
          "type": "BIOLOGICAL"
        },
        {
          "name": "%5 dextrose for infusion",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Pinteon Therapeutics, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 1,
      "start_date": "2021-03-29",
      "completion_date": "2021-04-12",
      "has_results": false,
      "last_update_posted_date": "2022-06-29",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04677829"
    },
    {
      "nct_id": "NCT01013870",
      "title": "Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Traumatic Brain Injury",
        "Post-traumatic Stress Disorder"
      ],
      "interventions": [
        {
          "name": "Atorvastatin",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 52,
      "start_date": "2010-02",
      "completion_date": "2015-06",
      "has_results": true,
      "last_update_posted_date": "2017-01-09",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 2,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01013870"
    },
    {
      "nct_id": "NCT02525432",
      "title": "Autologous Stem Cell Study for Adult TBI (Phase 2b)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Brain Injuries, Traumatic",
        "Brain Injuries, Acute",
        "TBI (Traumatic Brain Injury)"
      ],
      "interventions": [
        {
          "name": "Placebo Infusion",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Autologous BMMNC Infusion",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 37,
      "start_date": "2016-11-21",
      "completion_date": "2025-01",
      "has_results": false,
      "last_update_posted_date": "2024-05-09",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02525432"
    },
    {
      "nct_id": "NCT02064959",
      "title": "To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Subdural Hematoma, Traumatic"
      ],
      "interventions": [
        {
          "name": "Temperature management Zoll Intravascular Temperature Management device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 32,
      "start_date": "2014-03-22",
      "completion_date": "2019-02-07",
      "has_results": true,
      "last_update_posted_date": "2020-10-19",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 5,
      "location_summary": "Miami, Florida • Atlanta, Georgia • Cincinnati, Ohio + 2 more",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02064959"
    },
    {
      "nct_id": "NCT03287557",
      "title": "Dysregulated CNS Inflammation After Acute Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Traumatic Brain Injury",
        "Aneurysmal Subarachnoid Hemorrhage"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Kentucky",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "101 Years",
        "sex": "ALL",
        "summary": "18 Years to 101 Years"
      },
      "enrollment_count": 8,
      "start_date": "2018-01-02",
      "completion_date": "2019-05-24",
      "has_results": false,
      "last_update_posted_date": "2019-08-29",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03287557"
    },
    {
      "nct_id": "NCT04685772",
      "title": "Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Post-Concussion Syndrome",
        "Headache"
      ],
      "interventions": [
        {
          "name": "Methylprednisolone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 25,
      "start_date": "2021-04-01",
      "completion_date": "2026-12-01",
      "has_results": false,
      "last_update_posted_date": "2024-11-12",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 1,
      "location_summary": "Manhasset, New York",
      "locations": [
        {
          "city": "Manhasset",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04685772"
    },
    {
      "nct_id": "NCT07219108",
      "title": "Transcutaneous Auricular Vagus Enhanced Recovery in the NeuroICU",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Neurological Injury",
        "Acute Medical Conditions"
      ],
      "interventions": [
        {
          "name": "Auricular Vagus Nerve Stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Sham Auricular Vagus nerve Stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 160,
      "start_date": "2025-09-24",
      "completion_date": "2027-09-23",
      "has_results": false,
      "last_update_posted_date": "2025-10-21",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07219108"
    },
    {
      "nct_id": "NCT05049057",
      "title": "Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Posttraumatic Headache",
        "Mild Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Erenumab 140 Mg/mL Subcutaneous Solution",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Henry M. Jackson Foundation for the Advancement of Military Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 404,
      "start_date": "2022-07-19",
      "completion_date": "2027-05-19",
      "has_results": false,
      "last_update_posted_date": "2024-02-22",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 4,
      "location_summary": "Fort Bragg, North Carolina • Pittsburgh, Pennsylvania • El Paso, Texas + 1 more",
      "locations": [
        {
          "city": "Fort Bragg",
          "state": "North Carolina"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "El Paso",
          "state": "Texas"
        },
        {
          "city": "Tacoma",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05049057"
    },
    {
      "nct_id": "NCT01964664",
      "title": "Mindfulness Meditation for Subjects With Severe Speech and Physical Impairments",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Physical Impairments",
        "Cerebral Palsy",
        "Cerebral Ataxia",
        "locked-in Syndrome"
      ],
      "interventions": [
        {
          "name": "Mindfulness Meditation Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Audio Group",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 8,
      "start_date": "2013-01",
      "completion_date": "2016-10",
      "has_results": false,
      "last_update_posted_date": "2017-04-13",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 1,
      "location_summary": "Portland Metropolitan Area, Oregon",
      "locations": [
        {
          "city": "Portland Metropolitan Area",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01964664"
    },
    {
      "nct_id": "NCT04758052",
      "title": "Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stroke, Acute",
        "TBI",
        "Neuromuscular Diseases",
        "Status Epilepticus",
        "Coma",
        "Cerebrovascular Disorders",
        "Spinal Cord Injuries",
        "Neurological Injury",
        "Neurologic Injury"
      ],
      "interventions": [
        {
          "name": "Timing of placement",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Mississippi Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 0,
      "start_date": "2021-03-31",
      "completion_date": "2022-08",
      "has_results": false,
      "last_update_posted_date": "2021-06-09",
      "last_synced_at": "2026-05-21T23:18:49.177Z",
      "location_count": 1,
      "location_summary": "Jackson, Mississippi",
      "locations": [
        {
          "city": "Jackson",
          "state": "Mississippi"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04758052"
    }
  ]
}