{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Respiratory+Insufficiency&page=6",
    "query": {
      "condition": "Acute Respiratory Insufficiency",
      "page": 6
    },
    "page_size": 10
  },
  "pagination": {
    "page": 6,
    "page_size": 10,
    "total_count": 214,
    "total_pages": 22,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Respiratory+Insufficiency&page=7&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Respiratory+Insufficiency&page=5&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-08T20:47:22.676Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06501118",
      "title": "Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure",
        "Acute Hypoxemic Respiratory Failure",
        "Acute Hypoxic Respiratory Failure",
        "Hypoxemia",
        "Hypoxia",
        "Hypoxic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Education",
          "type": "OTHER"
        },
        {
          "name": "Epic notification alert",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 3600,
      "start_date": "2024-09-01",
      "completion_date": "2026-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-09-28",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06501118"
    },
    {
      "nct_id": "NCT06701682",
      "title": "JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome (ARDS)",
        "ARDS",
        "ARDS (Acute Respiratory Distress Syndrome)",
        "Acute Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Cohort A: vilobelimab",
          "type": "DRUG"
        },
        {
          "name": "Cohort A: placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "PPD Development, LP",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2025-06-21",
      "completion_date": "2028-09",
      "has_results": false,
      "last_update_posted_date": "2026-07-31",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 41,
      "location_summary": "Birmingham, Alabama • Fresno, California • Long Beach, California + 34 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Fresno",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06701682"
    },
    {
      "nct_id": "NCT04381923",
      "title": "COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Severe Acute Respiratory Syndrome Coronavirus 2",
        "Hypoxemic Respiratory Failure",
        "Pneumonia, Viral",
        "COVID"
      ],
      "interventions": [
        {
          "name": "Helmet Continuous Positive Airway Pressure (CPAP)",
          "type": "DEVICE"
        },
        {
          "name": "High Flow Nasal Oxygen (HFNO)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2021-11-15",
      "completion_date": "2022-12-15",
      "has_results": false,
      "last_update_posted_date": "2022-04-05",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04381923"
    },
    {
      "nct_id": "NCT03885726",
      "title": "HVNI Ambulation Feasibility Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Insufficiency",
        "Dyspnea"
      ],
      "interventions": [
        {
          "name": "Precision Flow Plus",
          "type": "DEVICE"
        },
        {
          "name": "Treatment as Usual",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vapotherm, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 32,
      "start_date": "2018-11-21",
      "completion_date": "2019-03-11",
      "has_results": true,
      "last_update_posted_date": "2020-10-19",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 3,
      "location_summary": "Saint Charles, Missouri • Mount Vernon, Ohio • Newport News, Virginia",
      "locations": [
        {
          "city": "Saint Charles",
          "state": "Missouri"
        },
        {
          "city": "Mount Vernon",
          "state": "Ohio"
        },
        {
          "city": "Newport News",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03885726"
    },
    {
      "nct_id": "NCT07224243",
      "title": "Impact of Intraoperative Oxygenation Practices on Patient Outcomes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Surgeries Undergoing General Anesthesia"
      ],
      "interventions": [
        {
          "name": "Lower FiO2",
          "type": "OTHER"
        },
        {
          "name": "Intermediate FiO2",
          "type": "OTHER"
        },
        {
          "name": "Higher FiO2",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Frederic T Billings IV",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 54000,
      "start_date": "2025-12-01",
      "completion_date": "2028-04",
      "has_results": false,
      "last_update_posted_date": "2026-09-16",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 4,
      "location_summary": "Ann Arbor, Michigan • Omaha, Nebraska • Nashville, Tennessee + 1 more",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Omaha",
          "state": "Nebraska"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07224243"
    },
    {
      "nct_id": "NCT01206166",
      "title": "Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Critical Illness",
        "Acute Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Olimel (5.7%E / N9E)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Clinical Evaluation Research Unit at Kingston General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 125,
      "start_date": "2011-06",
      "completion_date": "2015-07",
      "has_results": true,
      "last_update_posted_date": "2021-03-16",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 7,
      "location_summary": "Boulder, Colorado • St Louis, Missouri • Cleveland, Ohio + 3 more",
      "locations": [
        {
          "city": "Boulder",
          "state": "Colorado"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01206166"
    },
    {
      "nct_id": "NCT06701669",
      "title": "JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome (ARDS)",
        "ARDS",
        "ARDS (Acute Respiratory Distress Syndrome)",
        "Acute Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Cohort B: paridiprubart",
          "type": "DRUG"
        },
        {
          "name": "Cohort B: placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "PPD Development, LP",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2025-06-10",
      "completion_date": "2028-09",
      "has_results": false,
      "last_update_posted_date": "2026-07-31",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 41,
      "location_summary": "Birmingham, Alabama • Fresno, California • Long Beach, California + 34 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Fresno",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06701669"
    },
    {
      "nct_id": "NCT03642002",
      "title": "The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome",
        "Acute Hypoxemic Respiratory Failure",
        "Acute Hypercapnic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Toning",
          "type": "OTHER"
        },
        {
          "name": "Ocean drum & SOK melody",
          "type": "OTHER"
        },
        {
          "name": "SOK",
          "type": "OTHER"
        },
        {
          "name": "Process",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Holding Harmonic Container",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 178,
      "start_date": "2018-12-12",
      "completion_date": "2028-12",
      "has_results": false,
      "last_update_posted_date": "2025-04-09",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 3,
      "location_summary": "New York, New York • Houston, Texas",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Houston",
          "state": "Texas"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03642002"
    },
    {
      "nct_id": "NCT06934876",
      "title": "Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Colorimetric carbon dioxide (CO2) detection",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Waveform capnography",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Brian Driver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2092,
      "start_date": "2025-04-21",
      "completion_date": "2027-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-11",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 9,
      "location_summary": "Chicago, Illinois • Burlington, Massachusetts • Minneapolis, Minnesota + 6 more",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Burlington",
          "state": "Massachusetts"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Saint Paul",
          "state": "Minnesota"
        },
        {
          "city": "Albany",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06934876"
    },
    {
      "nct_id": "NCT04694638",
      "title": "Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation to Prevent Intubation in COVID-19 Infection",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prone Positioning",
        "Covid19",
        "Hypoxemic Respiratory Failure",
        "ARDS",
        "Non Invasive Ventilation",
        "High Flow Nasal Cannulla"
      ],
      "interventions": [
        {
          "name": "Body position change",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "110 Years",
        "sex": "ALL",
        "summary": "18 Years to 110 Years"
      },
      "enrollment_count": 6,
      "start_date": "2020-05-21",
      "completion_date": "2023-05-10",
      "has_results": false,
      "last_update_posted_date": "2023-10-05",
      "last_synced_at": "2026-10-08T20:47:22.676Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04694638"
    }
  ]
}