{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Severe+Pain&page=5",
    "query": {
      "condition": "Acute Severe Pain",
      "page": 5
    },
    "page_size": 10
  },
  "pagination": {
    "page": 5,
    "page_size": 10,
    "total_count": 463,
    "total_pages": 47,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Severe+Pain&page=6&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Acute+Severe+Pain&page=4&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-13T05:26:10.978Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03633604",
      "title": "Expanded Access IND Administration of HBOC-201 in Patients With Severe Acute Anemia",
      "overall_status": "NO_LONGER_AVAILABLE",
      "study_type": "EXPANDED_ACCESS",
      "phases": [],
      "conditions": [
        "Anemia Severe"
      ],
      "interventions": [
        {
          "name": "HBOC-201",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Michael Boisen",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2026-07-20",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03633604"
    },
    {
      "nct_id": "NCT05142306",
      "title": "A COVID-19 Study to Evaluate Safety and PK of COVID-HIG Administered Through IM, SC, or IV Routes to SARS-CoV-2 Uninfected Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "SARS-CoV-2 Infection"
      ],
      "interventions": [
        {
          "name": "COVID-HIG",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Emergent BioSolutions",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "18 Years to 59 Years"
      },
      "enrollment_count": 23,
      "start_date": "2021-12-07",
      "completion_date": "2022-05-31",
      "has_results": true,
      "last_update_posted_date": "2025-06-08",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 2,
      "location_summary": "Miami, Florida • Springfield, Missouri",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Springfield",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05142306"
    },
    {
      "nct_id": "NCT04421664",
      "title": "Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Corona Virus Infection",
        "SARS-CoV Infection",
        "Coronavirus"
      ],
      "interventions": [
        {
          "name": "Hydroxychloroquine",
          "type": "DRUG"
        },
        {
          "name": "Placebo oral tablet",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "McGill University Health Centre/Research Institute of the McGill University Health Centre",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2020-03-25",
      "completion_date": "2020-08-17",
      "has_results": false,
      "last_update_posted_date": "2024-10-15",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04421664"
    },
    {
      "nct_id": "NCT05263921",
      "title": "Relative Bioavailability Study of PF-07321332/Ritonavir Oral Powder Relative to the Commercial Tablets in Healthy Participants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Bioavailability"
      ],
      "interventions": [
        {
          "name": "PF-07321332/ritonavir",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 12,
      "start_date": "2022-03-10",
      "completion_date": "2022-05-19",
      "has_results": true,
      "last_update_posted_date": "2024-06-06",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05263921"
    },
    {
      "nct_id": "NCT02222714",
      "title": "Safety Evaluation of 3K3A-APC in Ischemic Stroke",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Ischemic Stroke"
      ],
      "interventions": [
        {
          "name": "3K3A-APC",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DRUG"
      ],
      "sponsor": "ZZ Biotech, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 110,
      "start_date": "2014-10",
      "completion_date": "2017-06-29",
      "has_results": true,
      "last_update_posted_date": "2018-11-08",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 15,
      "location_summary": "Los Angeles, California • Chicago, Illinois • Kansas City, Kansas + 12 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02222714"
    },
    {
      "nct_id": "NCT04077411",
      "title": "Approaches and Decisions for Acute Pediatric TBI Trial",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Severe Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Observational",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "Up to 18 Years"
      },
      "enrollment_count": 1000,
      "start_date": "2014-02-20",
      "completion_date": "2018-08-28",
      "has_results": false,
      "last_update_posted_date": "2023-12-08",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 30,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • La Jolla, California + 25 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04077411"
    },
    {
      "nct_id": "NCT04846010",
      "title": "Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Sequelae of; Infection",
        "Post Infection Glomerulonephritis",
        "Post-Infectious Peripheral Neuralgia",
        "Post-Infectious Disorder (Disorder)",
        "Post-Infectious Arthritis",
        "Post-Infectious Polyneuritis",
        "Post-Infectious Parkinsonism",
        "Post-Infectious Hypothyroidism",
        "Post Infectious Osteoarthritis",
        "Anxiety Disorders",
        "Depression",
        "Depression, Anxiety",
        "Depression, Bipolar",
        "Insomnia",
        "GERD",
        "Gastro Esophageal Reflux",
        "Hepatitis",
        "Glomerulonephritis"
      ],
      "interventions": [
        {
          "name": "PurWet",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "FurFat",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "PurApo",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "PurPhl",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "PurClo",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "PurInf",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Smoliv",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "All Natural Medicine Clinic, LLC",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 2000,
      "start_date": "2021-03-01",
      "completion_date": "2022-10-01",
      "has_results": false,
      "last_update_posted_date": "2021-05-26",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 1,
      "location_summary": "Rockville, Maryland",
      "locations": [
        {
          "city": "Rockville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04846010"
    },
    {
      "nct_id": "NCT00169962",
      "title": "Study of Pulmozyme to Treat Severe Asthma Episodes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Asthma"
      ],
      "interventions": [
        {
          "name": "rhDNAse (pulmozyme)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 51,
      "start_date": "2004-01",
      "completion_date": "2006-09",
      "has_results": false,
      "last_update_posted_date": "2015-10-12",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 1,
      "location_summary": "Queens, New York",
      "locations": [
        {
          "city": "Queens",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00169962"
    },
    {
      "nct_id": "NCT02598674",
      "title": "Severe Sepsis in Children - IMPRESS-C",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Kidney Injury",
        "Chronic Kidney Disease",
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Iodohippurate",
          "type": "DRUG"
        },
        {
          "name": "24 hour ambulatory Blood Pressure",
          "type": "PROCEDURE"
        },
        {
          "name": "Peripheral Arterial Tonometry",
          "type": "PROCEDURE"
        },
        {
          "name": "Pulse Wave Velocity",
          "type": "PROCEDURE"
        },
        {
          "name": "Gadolinium",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "7 Years to 17 Years"
      },
      "enrollment_count": 0,
      "start_date": "2019-10",
      "completion_date": "2021-09",
      "has_results": false,
      "last_update_posted_date": "2020-12-09",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 1,
      "location_summary": "Gainesville, Florida",
      "locations": [
        {
          "city": "Gainesville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02598674"
    },
    {
      "nct_id": "NCT01892709",
      "title": "Titration of Intravenous Hydromorphone",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Acute Severe Pain"
      ],
      "interventions": [
        {
          "name": "Hydromorphone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Montefiore Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "21 Years to 64 Years"
      },
      "enrollment_count": 215,
      "start_date": "2013-06",
      "completion_date": "2014-04",
      "has_results": true,
      "last_update_posted_date": "2023-05-31",
      "last_synced_at": "2026-10-13T05:26:10.978Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01892709"
    }
  ]
}