{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Adverse+Effect",
    "query": {
      "condition": "Adverse Effect"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 816,
    "total_pages": 82,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Adverse+Effect&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T03:49:57.172Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05411315",
      "title": "Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mechanical Ventilation Complication",
        "Arterial Thrombosis",
        "Limb Ischemia",
        "Shock",
        "Hypotension",
        "Bloodstream Infection",
        "Vasopressor Adverse Reaction",
        "Renal Failure"
      ],
      "interventions": [
        {
          "name": "Restricted-use of arterial catheter",
          "type": "OTHER"
        },
        {
          "name": "Standard-use of arterial catheter",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Dartmouth-Hitchcock Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 700,
      "start_date": "2022-10-17",
      "completion_date": "2023-07-14",
      "has_results": false,
      "last_update_posted_date": "2024-02-26",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 1,
      "location_summary": "Lebanon, New Hampshire",
      "locations": [
        {
          "city": "Lebanon",
          "state": "New Hampshire"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05411315"
    },
    {
      "nct_id": "NCT03038997",
      "title": "Early Detection of Cardiac Toxicity in Childhood Cancer Survivors",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Heart Failure",
        "Cardiotoxicity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Niti Dham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "8 Years to 25 Years"
      },
      "enrollment_count": 42,
      "start_date": "2014-11",
      "completion_date": "2018-03-11",
      "has_results": false,
      "last_update_posted_date": "2018-12-04",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03038997"
    },
    {
      "nct_id": "NCT04722497",
      "title": "Noise in the OR: A Quality Improvement Program",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Noise; Adverse Effect"
      ],
      "interventions": [
        {
          "name": "Sound Education",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1200,
      "start_date": "2021-01",
      "completion_date": "2023-12",
      "has_results": false,
      "last_update_posted_date": "2021-01-25",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04722497"
    },
    {
      "nct_id": "NCT02897843",
      "title": "The Effect of Transcranial Direct Current Stimulation on Cognitive Side Effects of Electroconvulsive Therapy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "transcranial magnetic stimulation",
          "type": "DEVICE"
        },
        {
          "name": "sham tDCS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 32,
      "start_date": "2017-02-16",
      "completion_date": "2019-04-19",
      "has_results": false,
      "last_update_posted_date": "2019-05-22",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 1,
      "location_summary": "Glen Oaks, New York",
      "locations": [
        {
          "city": "Glen Oaks",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02897843"
    },
    {
      "nct_id": "NCT06926478",
      "title": "Subconjunctival Humira for Boston Keratoprosthesis",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Penetrating Keratoplasty",
        "Multiple Graft Failure",
        "Ocular Cicatricial Pemphigoid",
        "Stevens-Johnson Syndrome"
      ],
      "interventions": [
        {
          "name": "Adalimumab Injection",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts Eye and Ear Infirmary",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 8,
      "start_date": "2026-06-01",
      "completion_date": "2028-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-03-27",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06926478"
    },
    {
      "nct_id": "NCT00047476",
      "title": "D-MPH in the Treatment of Fatigue and Neurobehavioral Function Related to Chemotherapy in Adult Cancer Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Fatigue",
        "Neoplasms"
      ],
      "interventions": [
        {
          "name": "dexmethylphenidate(d-mph)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Celgene Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 160,
      "start_date": "2002-06",
      "completion_date": "2004-03",
      "has_results": false,
      "last_update_posted_date": "2005-06-24",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 21,
      "location_summary": "Birmingham, Alabama • Flagstaff, Arizona • Tucson, Arizona + 17 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Flagstaff",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Berkeley",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00047476"
    },
    {
      "nct_id": "NCT03887247",
      "title": "Reducing Concurrent Opioid-Benzodiazepine Prescriptions",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Adverse Drug Effect of Opioids",
        "Adverse Drug Effect of Benzodiazepines"
      ],
      "interventions": [
        {
          "name": "E-mail Alert",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Walter Reed National Military Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2234,
      "start_date": "2019-06-06",
      "completion_date": "2022-06-01",
      "has_results": false,
      "last_update_posted_date": "2021-05-19",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03887247"
    },
    {
      "nct_id": "NCT01172717",
      "title": "Study of Panitumumab in the Treatment of Carcinoid Syndrome",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Carcinoid Syndrome"
      ],
      "interventions": [
        {
          "name": "Panitumumab",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Boston Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2013-07",
      "completion_date": "2013-07",
      "has_results": false,
      "last_update_posted_date": "2013-07-26",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • Burlington, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Burlington",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01172717"
    },
    {
      "nct_id": "NCT02076997",
      "title": "Individualized High Dose Methotrexate to Treat Cancer in Children Who Have a Significant Risk for Side Effects to Methotrexate",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cancer"
      ],
      "interventions": [
        {
          "name": "Methotrexate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Baylor College of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "22 Years",
        "sex": "ALL",
        "summary": "1 Year to 22 Years"
      },
      "enrollment_count": 23,
      "start_date": "2014-01-01",
      "completion_date": "2019-05-10",
      "has_results": true,
      "last_update_posted_date": "2021-02-24",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02076997"
    },
    {
      "nct_id": "NCT00003070",
      "title": "Enalapril in Treating Heart Damage Patients Who Received Anthracycline Chemotherapy for Childhood Cancer",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Cardiac Toxicity",
        "Unspecified Childhood Solid Tumor, Protocol Specific"
      ],
      "interventions": [
        {
          "name": "enalapril maleate",
          "type": "DRUG"
        },
        {
          "name": "quality-of-life assessment",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "Children's Oncology Group",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "8 Years and older"
      },
      "enrollment_count": 13,
      "start_date": "2000-09",
      "completion_date": "2007-03",
      "has_results": false,
      "last_update_posted_date": "2014-08-05",
      "last_synced_at": "2026-06-11T03:49:57.172Z",
      "location_count": 55,
      "location_summary": "Birmingham, Alabama • Mobile, Alabama • Little Rock, Arkansas + 43 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00003070"
    }
  ]
}