{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Adverse+Local+Tissue+Reaction",
    "query": {
      "condition": "Adverse Local Tissue Reaction"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T14:21:13.168Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04821245",
      "title": "Defining Normal Postoperative Magnetic Resonance Imaging After Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Local Anesthetic Complication",
        "Local Anesthetic Drug Adverse Reaction"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Benaroya Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 36,
      "start_date": "2018-12-04",
      "completion_date": "2019-08-02",
      "has_results": true,
      "last_update_posted_date": "2021-05-25",
      "last_synced_at": "2026-07-22T14:21:13.168Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04821245"
    },
    {
      "nct_id": "NCT05109000",
      "title": "Comparison of Subcutaneous Injection of Normal Saline and Bacteriostatic Saline",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Injection Site Irritation",
        "Injection Site Bruising",
        "Injection Site Discomfort",
        "Benzoic Acid Adverse Reaction",
        "Anesthesia, Local"
      ],
      "interventions": [
        {
          "name": "Sodium Chloride 0.9% Inj",
          "type": "DRUG"
        },
        {
          "name": "Bacteriostatic Sodium Chloride 0.9 % INJECTION VIAL (ML)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Jeffrey Alan Klein, MD",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 32,
      "start_date": "2021-11",
      "completion_date": "2022-01",
      "has_results": false,
      "last_update_posted_date": "2021-11-05",
      "last_synced_at": "2026-07-22T14:21:13.168Z",
      "location_count": 1,
      "location_summary": "San Juan Capistrano, California",
      "locations": [
        {
          "city": "San Juan Capistrano",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05109000"
    },
    {
      "nct_id": "NCT02255331",
      "title": "Using MRI To Detect Soft Tissue Reactions And Implant Integration As Related To Implant Modularity",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Complications; Arthroplasty",
        "Complications; Arthroplasty, Mechanical"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "21 Years to 95 Years"
      },
      "enrollment_count": 240,
      "start_date": "2017-09-15",
      "completion_date": "2026-08",
      "has_results": false,
      "last_update_posted_date": "2025-06-19",
      "last_synced_at": "2026-07-22T14:21:13.168Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02255331"
    },
    {
      "nct_id": "NCT01884532",
      "title": "ASR-XL Metal-on-Metal 522 Post-Market Surveillance Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Adverse Local Tissue Reaction",
        "Total Hip Arthroplasty"
      ],
      "interventions": [
        {
          "name": "ASR-XL Metal-on-Metal",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "DePuy Orthopaedics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 146,
      "start_date": "2013-05",
      "completion_date": "2016-08",
      "has_results": false,
      "last_update_posted_date": "2016-09-26",
      "last_synced_at": "2026-07-22T14:21:13.168Z",
      "location_count": 7,
      "location_summary": "Fort Collins, Colorado • Glenview, Illinois • Rockford, Illinois + 4 more",
      "locations": [
        {
          "city": "Fort Collins",
          "state": "Colorado"
        },
        {
          "city": "Glenview",
          "state": "Illinois"
        },
        {
          "city": "Rockford",
          "state": "Illinois"
        },
        {
          "city": "Las Vegas",
          "state": "Nevada"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01884532"
    },
    {
      "nct_id": "NCT01828801",
      "title": "Pinnacle Metal-on-Metal 522 Post-Market Surveillance Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pinnacle Metal-on-Metal",
        "Revised Pinnacle Metal-on-Metal",
        "Adverse Local Tissue Reaction",
        "Metal Ions",
        "Total Hip Arthroplasty"
      ],
      "interventions": [
        {
          "name": "Pinnacle Metal-on Metal",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "DePuy Orthopaedics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 276,
      "start_date": "2013-03",
      "completion_date": "2016-08",
      "has_results": false,
      "last_update_posted_date": "2016-09-26",
      "last_synced_at": "2026-07-22T14:21:13.168Z",
      "location_count": 8,
      "location_summary": "Orange, California • Fort Collins, Colorado • Lone Tree, Colorado + 5 more",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Fort Collins",
          "state": "Colorado"
        },
        {
          "city": "Lone Tree",
          "state": "Colorado"
        },
        {
          "city": "Syracuse",
          "state": "New York"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01828801"
    }
  ]
}