{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Amputation+Stump",
    "query": {
      "condition": "Amputation Stump"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 27,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Amputation+Stump&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:21:37.169Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03253328",
      "title": "N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Diabetes Mellitus",
        "Critical Limb Ischemia",
        "Lower Limb Amputation Knee",
        "Peripheral Arterial Disease"
      ],
      "interventions": [
        {
          "name": "Active Arm N-acetyl cysteine (NAC)",
          "type": "DRUG"
        },
        {
          "name": "Placebo Arm",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "30 Years to 90 Years"
      },
      "enrollment_count": 33,
      "start_date": "2017-03-01",
      "completion_date": "2022-06-27",
      "has_results": true,
      "last_update_posted_date": "2024-08-16",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03253328"
    },
    {
      "nct_id": "NCT01734837",
      "title": "TICAP - Titanium Clips for Appendiceal Stump Closure",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Appendicitis"
      ],
      "interventions": [
        {
          "name": "DS-Ligature Clip",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Aesculap AG",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 390,
      "start_date": "2011-10",
      "completion_date": "2013-08",
      "has_results": false,
      "last_update_posted_date": "2015-09-09",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 2,
      "location_summary": "Marina del Rey, California • Bethlehem, Pennsylvania",
      "locations": [
        {
          "city": "Marina del Rey",
          "state": "California"
        },
        {
          "city": "Bethlehem",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01734837"
    },
    {
      "nct_id": "NCT03544853",
      "title": "Computational Design, Fabrication, and Evaluation of Optimized Patient-Specific Transtibial Prosthetic Sockets",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation Stump"
      ],
      "interventions": [
        {
          "name": "Prosthetic socket for transtibial amputee",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts Institute of Technology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 10,
      "start_date": "2017-09-15",
      "completion_date": "2022-08-31",
      "has_results": false,
      "last_update_posted_date": "2022-09-30",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "Cambridge, Massachusetts",
      "locations": [
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03544853"
    },
    {
      "nct_id": "NCT01473992",
      "title": "Comparative Outcomes Assessment of the C-Leg With a New Knee Prosthesis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Other and Unspecified Complications of Amputation Stump"
      ],
      "interventions": [
        {
          "name": "Otto Bock C-Leg",
          "type": "DEVICE"
        },
        {
          "name": "Otto Bock Genium",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Jason Highsmith",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 25,
      "start_date": "2011-01",
      "completion_date": "2013-02",
      "has_results": true,
      "last_update_posted_date": "2023-12-12",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01473992"
    },
    {
      "nct_id": "NCT01800604",
      "title": "Power Over Pain (POP) Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Multiple Sclerosis",
        "Spinal Cord Injury",
        "Chronic Pain",
        "Other and Unspecified Amputation Stump Complications",
        "Muscular Dystrophies",
        "Low Back Pain"
      ],
      "interventions": [
        {
          "name": "Pain Self-Management Intervention #1",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pain Self-Management Intervention #2",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pain Self-Management Intervention #3",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Pain Self-Management Intervention #4",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 177,
      "start_date": "2013-02",
      "completion_date": "2018-01",
      "has_results": false,
      "last_update_posted_date": "2018-10-17",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01800604"
    },
    {
      "nct_id": "NCT00383682",
      "title": "Efficacy of Opioids and Mexiletine for the Treatment of Postamputation Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Amputation",
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "morphine and mexiletine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 60,
      "start_date": "1997-07",
      "completion_date": "2003-04",
      "has_results": false,
      "last_update_posted_date": "2006-10-03",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00383682"
    },
    {
      "nct_id": "NCT04427007",
      "title": "Moisture Management Liner Effectiveness Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation Stumps",
        "Amputees",
        "Amputation",
        "Lower Limb Deformities, Congenital",
        "Prosthesis User",
        "Prosthesis"
      ],
      "interventions": [
        {
          "name": "Moisture Management Liner",
          "type": "DEVICE"
        },
        {
          "name": "Control Liner",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Liberating Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 2,
      "start_date": "2020-07-01",
      "completion_date": "2022-01-16",
      "has_results": true,
      "last_update_posted_date": "2025-05-11",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "Holliston, Massachusetts",
      "locations": [
        {
          "city": "Holliston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04427007"
    },
    {
      "nct_id": "NCT01632709",
      "title": "Pathophysiology of Post Amputation Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Amputation Stumps",
        "Neuroma"
      ],
      "interventions": [
        {
          "name": "Bupivacaine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Shirley Ryan AbilityLab",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2012-05",
      "completion_date": "2014-12",
      "has_results": true,
      "last_update_posted_date": "2015-07-21",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01632709"
    },
    {
      "nct_id": "NCT05124873",
      "title": "Moisture Management Liner At-Home Evaluation",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Amputation Stump",
        "Amputation",
        "Amputees",
        "Lower Limb Deformity",
        "Prosthesis User",
        "Prosthesis"
      ],
      "interventions": [
        {
          "name": "Moisture Management Liner",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Liberating Technologies, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 1,
      "start_date": "2021-05-12",
      "completion_date": "2022-09-27",
      "has_results": true,
      "last_update_posted_date": "2025-06-17",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "Holliston, Massachusetts",
      "locations": [
        {
          "city": "Holliston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05124873"
    },
    {
      "nct_id": "NCT00771862",
      "title": "Prevention of Phantom Limb and Stump Pain Using Ambulatory Continuous Peripheral Nerve Blocks: A Pilot Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Amputation",
        "Phantom Limb Pain",
        "Stump Pain"
      ],
      "interventions": [
        {
          "name": "perineural ropivicaine",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 16,
      "start_date": "2008-10",
      "completion_date": "2017-05-30",
      "has_results": false,
      "last_update_posted_date": "2018-03-19",
      "last_synced_at": "2026-05-22T08:21:37.169Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00771862"
    }
  ]
}