{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Amputation+of+Lower+Limb+Below+Knee", "query": { "condition": "Amputation of Lower Limb Below Knee" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 28, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Amputation+of+Lower+Limb+Below+Knee&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-30T02:41:30.510Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07215442", "title": "Skin Temperature Perception and Prosthetic Thermoregulation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lower Limb Amputation Below Knee", "Diabetes (DM)", "Skin Temperature Change", "Vascular Reactivity" ], "interventions": [ { "name": "Warming stimulus starting at 30 C initial temperature", "type": "OTHER" }, { "name": "Warming stimulus starting at 32 C initial temperature", "type": "OTHER" }, { "name": "Warming stimulus starting at 34 C initial temperature", "type": "OTHER" }, { "name": "Warming stimulus starting at 35 C initial temperature", "type": "OTHER" }, { "name": "Cooling stimulus starting at 30 C initial temperature", "type": "OTHER" }, { "name": "Cooling stimulus starting at 32 C initial temperature", "type": "OTHER" }, { "name": "Cooling stimulus starting at 34 C initial temperature", "type": "OTHER" }, { "name": "Cooling stimulus starting at 35 C initial temperature", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "VA Puget Sound Health Care System", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 56, "start_date": "2011-04-28", "completion_date": "2013-08-09", "has_results": false, "last_update_posted_date": "2025-10-10", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT07215442" }, { "nct_id": "NCT06711588", "title": "Automatic Prosthetic Foot Stiffness Modulation to Improve Balance", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lower Limb Amputation Below Knee" ], "interventions": [ { "name": "As-prescribed stiffness", "type": "DEVICE" }, { "name": "Two categories stiffer than the as-prescribed stiffness", "type": "DEVICE" }, { "name": "Two categories less stiff than the as-prescribed stiffness", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Seattle Institute for Biomedical and Clinical Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 21, "start_date": "2024-12-19", "completion_date": "2026-07-24", "has_results": false, "last_update_posted_date": "2026-08-07", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT06711588" }, { "nct_id": "NCT05265403", "title": "Evaluation of High-Performance, Customized, Rapidly-Manufacturable Prosthetic Feet That Provide Improved Mobility", "overall_status": "UNKNOWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Amputation of Lower Limb Below Knee" ], "interventions": [ { "name": "Commercially-available energy storage and return prosthetic foot", "type": "DRUG" }, { "name": "MIT-Lower Leg Trajectory Error (LLTE) customized prosthetic feet", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Massachusetts Institute of Technology", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 40, "start_date": "2022-03-03", "completion_date": "2022-08-31", "has_results": false, "last_update_posted_date": "2022-04-12", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT05265403" }, { "nct_id": "NCT07664995", "title": "Determining the Effects of Ischemic Conditioning and Neuromuscular Electrical Stimulation on Overall Function After Lower Limb Amputation", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lower Limb Amputation Above Knee", "Below Knee Amputation" ], "interventions": [ { "name": "Blood pressure cuff", "type": "DEVICE" }, { "name": "Neuromuscular Electrical Stimulation", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Illinois at Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 24, "start_date": "2026-07-01", "completion_date": "2027-12", "has_results": false, "last_update_posted_date": "2026-06-24", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT07664995" }, { "nct_id": "NCT04937179", "title": "The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Peripheral Arterial Disease", "Peripheral Vascular Disease", "Amputation", "Lower Limb Amputation Knee", "Lower Limb Amputation Above Knee (Injury)", "Lower Limb Amputation Below Knee (Injury)" ], "interventions": [ { "name": "Ischemic Conditioning Low - Sham Comparator", "type": "PROCEDURE" }, { "name": "Ischemic Conditioning High - Active Comparator", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "University of Illinois at Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 21, "start_date": "2022-07-01", "completion_date": "2024-12-31", "has_results": false, "last_update_posted_date": "2025-02-27", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04937179" }, { "nct_id": "NCT07397169", "title": "Adjustable Prosthetic Sockets for Individuals With Lower Limb Amputation", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lower Extremity Amputation" ], "interventions": [ { "name": "Adjustable prosthetic socket", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 25, "start_date": "2026-10-01", "completion_date": "2029-08-01", "has_results": false, "last_update_posted_date": "2026-07-20", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT07397169" }, { "nct_id": "NCT05915065", "title": "VR to Evaluate Phantom Limb Pain", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Phantom Limb Pain", "Phantom Pain", "Phantom Sensation", "Phantom Limb Syndrome With Pain", "Phantom Pain Following Amputation of Lower Limb", "Phantom Pain Following Amputation of Upper Limb", "Amputation", "Upper Limb Amputation at the Hand", "Upper Limb Amputation at the Wrist", "Upper Limb Amputation Below Elbow (Injury)", "Upper Limb Amputation Above Elbow (Injury)", "Lower Limb Amputation Knee", "Lower Limb Amputation Above Knee (Injury)", "Lower Limb Amputation Below Knee (Injury)", "Lower Limb Amputation at Ankle (Injury)" ], "interventions": [ { "name": "Coapt Phantom Limb Pain Management System", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Shirley Ryan AbilityLab", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 48, "start_date": "2020-10-01", "completion_date": "2025-09-30", "has_results": false, "last_update_posted_date": "2025-03-14", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT05915065" }, { "nct_id": "NCT03532100", "title": "Pivot-Flex Foot: Optimal Coupling Ratio Between Transverse and Sagittal-plane Motions Using a Torsionally Adaptive Prosthesis for Individuals With Lower Limb Amputation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lower Extremity Amputation" ], "interventions": [ { "name": "Torsionally adaptive prosthesis with 0:1 coupling ratio", "type": "DEVICE" }, { "name": "Torsionally adaptive prosthesis with 1:6 coupling ratio", "type": "DEVICE" }, { "name": "Torsionally adaptive prosthesis with 1:4 coupling ratio", "type": "DEVICE" }, { "name": "Torsionally adaptive prosthesis with 1:3 coupling ratio", "type": "DEVICE" }, { "name": "Torsionally adaptive prosthesis with 1:2 coupling ratio", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 14, "start_date": "2018-04-18", "completion_date": "2024-11-18", "has_results": true, "last_update_posted_date": "2025-11-19", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT03532100" }, { "nct_id": "NCT05425810", "title": "R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Lower Limb Amputation Below Knee (Injury)" ], "interventions": [ { "name": "Apply ENABLE sensing pad", "type": "DEVICE" }, { "name": "Insert small pads at pressure tolerant locations", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "North Carolina State University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "99 Years", "sex": "ALL", "summary": "18 Years to 99 Years" }, "enrollment_count": 3, "start_date": "2021-04-20", "completion_date": "2026-02-27", "has_results": false, "last_update_posted_date": "2025-05-20", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Raleigh, North Carolina", "locations": [ { "city": "Raleigh", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT05425810" }, { "nct_id": "NCT02124915", "title": "Influence of Socket Volume on Prosthesis Performance", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Lower Limb Amputation Below Knee (Injury)" ], "interventions": [], "intervention_types": [], "sponsor": "University of Washington", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 9, "start_date": "2013-02", "completion_date": "2014-12", "has_results": false, "last_update_posted_date": "2017-08-24", "last_synced_at": "2026-09-30T02:41:30.510Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT02124915" } ] }