{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Anxious+Major+Depressive+Disorder&page=4",
    "query": {
      "condition": "Anxious Major Depressive Disorder",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 140,
    "total_pages": 14,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Anxious+Major+Depressive+Disorder&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Anxious+Major+Depressive+Disorder&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-08T09:53:26.505Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04293341",
      "title": "Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder",
        "Posttraumatic Stress Disorder",
        "Panic Disorder and Agoraphobia"
      ],
      "interventions": [
        {
          "name": "Transdiagnostic Behavior Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Processing Therapy for PTSD",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Behavioral Therapy for MDD",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Behavioral Therapy for Panic Disorder",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 304,
      "start_date": "2020-10-01",
      "completion_date": "2025-03-31",
      "has_results": true,
      "last_update_posted_date": "2025-11-06",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04293341"
    },
    {
      "nct_id": "NCT06646692",
      "title": "Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Posttraumatic Stress Disorder (PTSD)",
        "Anxiety",
        "Depression - Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Mindful Self Compassion",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Treatment as Usual (TAU)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 230,
      "start_date": "2024-05-05",
      "completion_date": "2025-11-21",
      "has_results": false,
      "last_update_posted_date": "2026-06-01",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 1,
      "location_summary": "Pomona, California",
      "locations": [
        {
          "city": "Pomona",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06646692"
    },
    {
      "nct_id": "NCT05189977",
      "title": "A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Post-traumatic Stress Disorder (PTSD)"
      ],
      "interventions": [
        {
          "name": "Propranolol",
          "type": "DRUG"
        },
        {
          "name": "Prazosin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 34,
      "start_date": "2022-09-07",
      "completion_date": "2023-08-03",
      "has_results": false,
      "last_update_posted_date": "2024-01-23",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 1,
      "location_summary": "Princeton, New Jersey",
      "locations": [
        {
          "city": "Princeton",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05189977"
    },
    {
      "nct_id": "NCT06493825",
      "title": "Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tinnitus",
        "Misophonia"
      ],
      "interventions": [
        {
          "name": "Aurora Mindfulness app versus sham",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "10 Years to 18 Years"
      },
      "enrollment_count": 30,
      "start_date": "2024-09-01",
      "completion_date": "2025-12-15",
      "has_results": false,
      "last_update_posted_date": "2025-04-16",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06493825"
    },
    {
      "nct_id": "NCT03925168",
      "title": "Music Therapy and Dialysis: A Pilot Investigation Into the Effectiveness of Patient-Selected Music Interventions on Physiological, Psychological, and Quality-of-Life Outcomes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "End Stage Renal Disease",
        "Depression",
        "Anxiety",
        "Major Depressive Disorder",
        "Generalized Anxiety Disorder",
        "Compliance, Patient",
        "Compliance, Medication",
        "Mood",
        "Pain",
        "Energy Supply; Deficiency",
        "Quality of Life",
        "Blood Pressure",
        "Heart Rate Fast"
      ],
      "interventions": [
        {
          "name": "Music therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Tulane University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2019-03-08",
      "completion_date": "2020-01-01",
      "has_results": false,
      "last_update_posted_date": "2021-01-15",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 3,
      "location_summary": "New Orleans, Louisiana • Terrytown, Louisiana",
      "locations": [
        {
          "city": "New Orleans",
          "state": "Louisiana"
        },
        {
          "city": "New Orleans",
          "state": "Louisiana"
        },
        {
          "city": "Terrytown",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03925168"
    },
    {
      "nct_id": "NCT01652768",
      "title": "PRESENCE Project: An Early Palliative Care Intervention in Brain Tumors",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Malignant Brain Tumors"
      ],
      "interventions": [
        {
          "name": "Research Questionnaires",
          "type": "OTHER"
        },
        {
          "name": "Palliative Care Team",
          "type": "OTHER"
        },
        {
          "name": "Educational Information Session for Patients and Caregivers",
          "type": "OTHER"
        },
        {
          "name": "Contact every 2 weeks",
          "type": "OTHER"
        },
        {
          "name": "Follow-up Surgical Visit Session",
          "type": "OTHER"
        },
        {
          "name": "Medical and/or Radiation Oncology Appointment Session",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Case Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1,
      "start_date": "2011-12",
      "completion_date": "2013-08",
      "has_results": false,
      "last_update_posted_date": "2013-08-29",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01652768"
    },
    {
      "nct_id": "NCT02196506",
      "title": "Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Depressive Disorder",
        "Depression",
        "Depressive Disorder, Major",
        "Mood Disorders",
        "Mental Disorders"
      ],
      "interventions": [
        {
          "name": "Placebo + ADT",
          "type": "DRUG"
        },
        {
          "name": "Brexpiprazole +ADT",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 837,
      "start_date": "2014-07",
      "completion_date": "2016-05",
      "has_results": true,
      "last_update_posted_date": "2018-08-21",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 30,
      "location_summary": "Birmingham, Alabama • Beverly Hills, California • Denver, Colorado + 27 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Hialeah",
          "state": "Florida"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02196506"
    },
    {
      "nct_id": "NCT03674138",
      "title": "Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depression",
        "Anxiety",
        "Generalized Anxiety Disorder",
        "Depressive Disorder",
        "Major Depressive Disorder",
        "Cancer"
      ],
      "interventions": [
        {
          "name": "DNA-guided choice of therapy",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Clinical management",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST",
        "OTHER"
      ],
      "sponsor": "H. Lee Moffitt Cancer Center and Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 99,
      "start_date": "2018-09-12",
      "completion_date": "2024-10-27",
      "has_results": false,
      "last_update_posted_date": "2026-02-06",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03674138"
    },
    {
      "nct_id": "NCT01230047",
      "title": "Mindfulness and Lifestyle Interventions for Depression and Anxiety: A Pilot Study",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depression",
        "Anxiety",
        "Major Depression"
      ],
      "interventions": [
        {
          "name": "Psychoeducational course",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Arizona State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 30,
      "start_date": "2010-10",
      "completion_date": "2011-10",
      "has_results": false,
      "last_update_posted_date": "2010-10-28",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01230047"
    },
    {
      "nct_id": "NCT06823024",
      "title": "Assess the Utility of a Speech-based Machine Learning Algorithm to Predict Treatment Response to Psychiatric Interventions",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Obsessive Compulsive Disorder (OCD)",
        "Bipolar Disorders",
        "Major Depressive Disorder",
        "Post-Traumatic Stress Disorder, PTSD",
        "Generalized Anxiety Disorder (GAD)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Psyrin Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "68 Years",
        "sex": "ALL",
        "summary": "18 Years to 68 Years"
      },
      "enrollment_count": 200,
      "start_date": "2025-02-18",
      "completion_date": "2026-03",
      "has_results": false,
      "last_update_posted_date": "2025-03-18",
      "last_synced_at": "2026-10-08T09:53:26.505Z",
      "location_count": 2,
      "location_summary": "Sunnyvale, California • New York, New York",
      "locations": [
        {
          "city": "Sunnyvale",
          "state": "California"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06823024"
    }
  ]
}