{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Aphasia+Non+Fluent",
    "query": {
      "condition": "Aphasia Non Fluent"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 17,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Aphasia+Non+Fluent&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T08:57:41.176Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01818661",
      "title": "Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "PPA",
        "Non-fluent Aphasia",
        "Apraxia of Speech",
        "Primary Progressive Non-fluent Aphasia",
        "Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "AV-1451",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2018-07-01",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2025-11-12",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01818661"
    },
    {
      "nct_id": "NCT02226796",
      "title": "Transcranial Direct Stimulation (tDCS) and Behavioral Intervention in Aphasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aphasia"
      ],
      "interventions": [
        {
          "name": "Transcranial direct current stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "20 Years to 85 Years"
      },
      "enrollment_count": 3,
      "start_date": "2015-09-01",
      "completion_date": "2018-12-01",
      "has_results": true,
      "last_update_posted_date": "2022-10-18",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02226796"
    },
    {
      "nct_id": "NCT03887481",
      "title": "Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Logopenic Progressive Aphasia",
        "Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "High-definition active tDCS (HD-tDCS) + \"Repeat After Me\" (RAM) Treatment",
          "type": "DEVICE"
        },
        {
          "name": "Sham + \"Repeat After Me\" (RAM) Treatment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "50 Years to 80 Years"
      },
      "enrollment_count": 60,
      "start_date": "2022-10-15",
      "completion_date": "2027-10-31",
      "has_results": false,
      "last_update_posted_date": "2025-09-15",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03887481"
    },
    {
      "nct_id": "NCT00903266",
      "title": "Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Aphasia",
        "Stroke",
        "Cerebrovascular Accident",
        "Apoplexy",
        "Cerebral Infarction"
      ],
      "interventions": [
        {
          "name": "Melodic Intonation Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Speech-Repetition-Therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 30,
      "start_date": "2008-02",
      "completion_date": "2020-06",
      "has_results": false,
      "last_update_posted_date": "2020-09-21",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00903266"
    },
    {
      "nct_id": "NCT02514044",
      "title": "Dextroamphetamine and tDCS to Improve the Fluency",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Stroke"
      ],
      "interventions": [
        {
          "name": "Dexedrine",
          "type": "DRUG"
        },
        {
          "name": "Active tDCS",
          "type": "DEVICE"
        },
        {
          "name": "Speech Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        },
        {
          "name": "Sham tDCS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE",
        "BEHAVIORAL"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2015-03",
      "completion_date": "2015-12",
      "has_results": true,
      "last_update_posted_date": "2018-08-03",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02514044"
    },
    {
      "nct_id": "NCT06185023",
      "title": "Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aphasia, Acquired",
        "Aphasia",
        "Aphasia, Fluent",
        "Aphasia Non Fluent"
      ],
      "interventions": [
        {
          "name": "Low-intensity physical exercise",
          "type": "BEHAVIORAL"
        },
        {
          "name": "High-intensity physical exercise",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of California, Berkeley",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 12,
      "start_date": "2023-12-11",
      "completion_date": "2026-01-15",
      "has_results": false,
      "last_update_posted_date": "2026-02-17",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 4,
      "location_summary": "Berkeley, California • Hayward, California • San Francisco, California",
      "locations": [
        {
          "city": "Berkeley",
          "state": "California"
        },
        {
          "city": "Hayward",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06185023"
    },
    {
      "nct_id": "NCT03313011",
      "title": "The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Apraxia of Speech",
        "Non-fluent Aphasia",
        "Primary Progressive Aphasia",
        "Primary Progressive Nonfluent Aphasia"
      ],
      "interventions": [
        {
          "name": "Testing protocol for the study",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 47,
      "start_date": "2017-08-01",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2026-05-01",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03313011"
    },
    {
      "nct_id": "NCT07036406",
      "title": "Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Aphasia",
        "Aphasia Following Cerebral Infarction",
        "Aphasia, Acquired",
        "Aphasia, Rehabilitation",
        "Aphasia, Anomic",
        "Aphasia, Broca",
        "Aphasia, Conduction",
        "Aphasia, Expressive",
        "Aphasia Non Fluent",
        "Aphasia, Mixed"
      ],
      "interventions": [
        {
          "name": "Semantic Feature Analysis (traditional)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Semantic Feature Analysis + Metacognitive Strategy Training",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Teachers College, Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 40,
      "start_date": "2025-07-28",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2026-06-25",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07036406"
    },
    {
      "nct_id": "NCT03406429",
      "title": "rTMS as a Treatment for PPA",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Logopenic Variant Primary Progressive Aphasia",
        "Non-Fluent Primary Progressive Aphasia"
      ],
      "interventions": [
        {
          "name": "Active rTMS",
          "type": "DEVICE"
        },
        {
          "name": "SHAM rTMS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 12,
      "start_date": "2019-12-01",
      "completion_date": "2022-01-01",
      "has_results": false,
      "last_update_posted_date": "2022-04-07",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03406429"
    },
    {
      "nct_id": "NCT05561400",
      "title": "Combining tDCS and CILT in Non-fluent Aphasia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Aphasia",
        "Non-fluent Aphasia",
        "Stroke",
        "Brain Injuries"
      ],
      "interventions": [
        {
          "name": "tDCS",
          "type": "DEVICE"
        },
        {
          "name": "Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2023-04-24",
      "completion_date": "2023-12-15",
      "has_results": true,
      "last_update_posted_date": "2025-12-09",
      "last_synced_at": "2026-07-22T08:57:41.176Z",
      "location_count": 1,
      "location_summary": "Duluth, Minnesota",
      "locations": [
        {
          "city": "Duluth",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05561400"
    }
  ]
}