{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Apnea+of+Prematurity",
    "query": {
      "condition": "Apnea of Prematurity"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 31,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Apnea+of+Prematurity&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T06:45:28.682Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00182312",
      "title": "Caffeine for Apnea of Prematurity (CAP)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Apnea of Prematurity"
      ],
      "interventions": [
        {
          "name": "Caffeine citrate injection",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "McMaster University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "10 Days",
        "sex": "ALL",
        "summary": "Up to 10 Days"
      },
      "enrollment_count": 2000,
      "start_date": "1999-10",
      "completion_date": "2016-07",
      "has_results": false,
      "last_update_posted_date": "2018-03-22",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Brooklyn, New York",
      "locations": [
        {
          "city": "Brooklyn",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00182312"
    },
    {
      "nct_id": "NCT05298748",
      "title": "The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Apnea of Prematurity",
        "Intermittent Hypoxemia",
        "Bradycardia"
      ],
      "interventions": [
        {
          "name": "Womb sound recordings",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Case Western Reserve University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Week",
        "maximum_age": "5 Weeks",
        "sex": "ALL",
        "summary": "1 Week to 5 Weeks"
      },
      "enrollment_count": 34,
      "start_date": "2022-09-16",
      "completion_date": "2026-11",
      "has_results": false,
      "last_update_posted_date": "2025-12-05",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05298748"
    },
    {
      "nct_id": "NCT03414671",
      "title": "The Effect of Standardizing the Definition of a Clinically Significant Cardiopulmonary Event on Length of Stay",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Apnea of Prematurity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Pediatrix",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "23 Weeks",
        "maximum_age": "29 Weeks",
        "sex": "ALL",
        "summary": "23 Weeks to 29 Weeks"
      },
      "enrollment_count": 160,
      "start_date": "2018-06-01",
      "completion_date": "2021-09-21",
      "has_results": false,
      "last_update_posted_date": "2021-10-04",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03414671"
    },
    {
      "nct_id": "NCT06849596",
      "title": "Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Resuscitation",
        "Apnea Neonatal"
      ],
      "interventions": [
        {
          "name": "Ventilator derived positive pressure ventilation - V-PPV",
          "type": "DEVICE"
        },
        {
          "name": "T-piece resuscitator (TPR)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Michelle Baczynski",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Weeks",
        "maximum_age": "29 Weeks",
        "sex": "ALL",
        "summary": "25 Weeks to 29 Weeks"
      },
      "enrollment_count": 780,
      "start_date": "2025-12-01",
      "completion_date": "2029-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-06",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06849596"
    },
    {
      "nct_id": "NCT01825473",
      "title": "Study of Erythromycin in GER-Associated Apnea of the Newborn",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Gastroesophageal Reflux",
        "Apnea",
        "Bradycardia"
      ],
      "interventions": [
        {
          "name": "Erythromycin",
          "type": "DRUG"
        },
        {
          "name": "Multi-channel intra-luminal impedance (MII) pH monitoring",
          "type": "DEVICE"
        },
        {
          "name": "Placebo (D5W)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Days",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "14 Days and older"
      },
      "enrollment_count": 40,
      "start_date": "2012-09",
      "completion_date": "2014-06",
      "has_results": false,
      "last_update_posted_date": "2013-04-05",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01825473"
    },
    {
      "nct_id": "NCT01875159",
      "title": "Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Hypoxia"
      ],
      "interventions": [
        {
          "name": "Caffeine citrate 6 mg/kg/day",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "American SIDS Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "33 Weeks",
        "maximum_age": "37 Weeks",
        "sex": "ALL",
        "summary": "33 Weeks to 37 Weeks"
      },
      "enrollment_count": 98,
      "start_date": "2010-07",
      "completion_date": "2011-12",
      "has_results": true,
      "last_update_posted_date": "2015-03-17",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01875159"
    },
    {
      "nct_id": "NCT03333174",
      "title": "Prematurity Related Ventilatory Control (PRE-VENT) - Specific Aim 3",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infant,Premature"
      ],
      "interventions": [
        {
          "name": "Cardiorespiratory monitoring",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "98 Days",
        "sex": "ALL",
        "summary": "1 Day to 98 Days"
      },
      "enrollment_count": 25,
      "start_date": "2018-04-09",
      "completion_date": "2021-07-01",
      "has_results": false,
      "last_update_posted_date": "2021-09-21",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03333174"
    },
    {
      "nct_id": "NCT03695900",
      "title": "Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Apnea of Prematurity",
        "Desaturation of Blood",
        "Central Apnea",
        "Periodic Breathing",
        "Obstructive Apnea of Newborn"
      ],
      "interventions": [
        {
          "name": "Targeting SpO2 at 93-95%",
          "type": "OTHER"
        },
        {
          "name": "Targeting SpO2 at 90-92%",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "18 Weeks",
        "sex": "ALL",
        "summary": "Up to 18 Weeks"
      },
      "enrollment_count": 19,
      "start_date": "2018-11-01",
      "completion_date": "2019-11-08",
      "has_results": false,
      "last_update_posted_date": "2023-05-10",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03695900"
    },
    {
      "nct_id": "NCT06327152",
      "title": "Caffeine Use in the Management of Preterm Infants",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Apnea of Prematurity"
      ],
      "interventions": [
        {
          "name": "Caffeine",
          "type": "DRUG"
        },
        {
          "name": "Sterile Water Placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "University of California, Irvine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Week",
        "maximum_age": "40 Weeks",
        "sex": "ALL",
        "summary": "1 Week to 40 Weeks"
      },
      "enrollment_count": 80,
      "start_date": "2024-02-22",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-11-10",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 1,
      "location_summary": "Orange, California",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06327152"
    },
    {
      "nct_id": "NCT03340727",
      "title": "Moderately Preterm Infants With Caffeine at Home for Apnea (MoCHA) Trial",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Apnea of Prematurity"
      ],
      "interventions": [
        {
          "name": "Caffeine Citrate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NICHD Neonatal Research Network",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "29 Weeks",
        "maximum_age": "33 Weeks",
        "sex": "ALL",
        "summary": "29 Weeks to 33 Weeks"
      },
      "enrollment_count": 827,
      "start_date": "2019-02-27",
      "completion_date": "2023-03-20",
      "has_results": true,
      "last_update_posted_date": "2024-07-31",
      "last_synced_at": "2026-05-22T06:45:28.682Z",
      "location_count": 16,
      "location_summary": "Birmingham, Alabama • Palo Alto, California • Atlanta, Georgia + 12 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03340727"
    }
  ]
}