{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Appearance+of+Facial+Wrinkles",
    "query": {
      "condition": "Appearance of Facial Wrinkles"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 5,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T01:43:36.870Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05011461",
      "title": "The Effect of Topical Almond Oil vs. Topical Retinol on The Appearance of Facial Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkles",
        "Skin"
      ],
      "interventions": [
        {
          "name": "Almond Oil",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, Davis",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "40 Years and older · Female only"
      },
      "enrollment_count": 40,
      "start_date": "2021-05-17",
      "completion_date": "2022-10-05",
      "has_results": false,
      "last_update_posted_date": "2023-02-14",
      "last_synced_at": "2026-07-23T01:43:36.870Z",
      "location_count": 1,
      "location_summary": "Sacramento, California",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05011461"
    },
    {
      "nct_id": "NCT05082766",
      "title": "Improvement in the Appearance of Periorbital Wrinkles",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Periorbital Wrinkles"
      ],
      "interventions": [
        {
          "name": "enhanced DefenAge 8-in-1 BioSerum",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "31 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "31 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2021-10-11",
      "completion_date": "2022-12-01",
      "has_results": false,
      "last_update_posted_date": "2021-10-28",
      "last_synced_at": "2026-07-23T01:43:36.870Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05082766"
    },
    {
      "nct_id": "NCT05524779",
      "title": "BTL-785F Device for Non-invasive Reduction of Wrinkles and Overall Facial Improvement",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "BTL-785-7",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "BTL Industries Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2022-10-19",
      "completion_date": "2024-06-25",
      "has_results": false,
      "last_update_posted_date": "2024-12-10",
      "last_synced_at": "2026-07-23T01:43:36.870Z",
      "location_count": 5,
      "location_summary": "Gilbert, Arizona • San Marcos, California • Davie, Florida + 2 more",
      "locations": [
        {
          "city": "Gilbert",
          "state": "Arizona"
        },
        {
          "city": "San Marcos",
          "state": "California"
        },
        {
          "city": "Davie",
          "state": "Florida"
        },
        {
          "city": "Macon",
          "state": "Georgia"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05524779"
    },
    {
      "nct_id": "NCT01299103",
      "title": "Safety and Efficacy of Single Therapy Versus Double and Triple Therapy of the Pellevé™ Wrinkle Treatment System for the Treatment of Moderate Facial Wrinkles",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Appearance of Facial Wrinkles"
      ],
      "interventions": [
        {
          "name": "Pelleve Wrinkle Treatment System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Ellman International",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "35 Years to 60 Years · Female only"
      },
      "enrollment_count": 40,
      "start_date": "2010-04",
      "completion_date": "2012-04",
      "has_results": true,
      "last_update_posted_date": "2016-04-15",
      "last_synced_at": "2026-07-23T01:43:36.870Z",
      "location_count": 1,
      "location_summary": "Chichago, Illinois",
      "locations": [
        {
          "city": "Chichago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01299103"
    },
    {
      "nct_id": "NCT05524805",
      "title": "BTL-785F Device for Non-invasive Treatment of Wrinkles and Improvement of the Face Appearance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Wrinkle"
      ],
      "interventions": [
        {
          "name": "BTL-785-7 Treatment",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "BTL Industries Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 23,
      "start_date": "2022-06-28",
      "completion_date": "2024-04-09",
      "has_results": false,
      "last_update_posted_date": "2024-12-06",
      "last_synced_at": "2026-07-23T01:43:36.870Z",
      "location_count": 2,
      "location_summary": "Greenwood Village, Colorado • Spring Hill, Tennessee",
      "locations": [
        {
          "city": "Greenwood Village",
          "state": "Colorado"
        },
        {
          "city": "Spring Hill",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05524805"
    }
  ]
}