{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Arthroplasties%2C+Knee+Replacement",
    "query": {
      "condition": "Arthroplasties, Knee Replacement"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 829,
    "total_pages": 83,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Arthroplasties%2C+Knee+Replacement&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-07T23:43:07.141Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05644496",
      "title": "ZYNRELEF for Pain Management in Total Knee Arthroplasty",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Post Operative Pain",
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "Bupivacaine-Meloxicam 400 Mg-12 Mg/14 mL Injectable Solution, Extended Release",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Baptist Health South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "35 Years to 70 Years"
      },
      "enrollment_count": 29,
      "start_date": "2023-03-09",
      "completion_date": "2025-12-19",
      "has_results": false,
      "last_update_posted_date": "2026-05-28",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05644496"
    },
    {
      "nct_id": "NCT03747146",
      "title": "Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anesthesia"
      ],
      "interventions": [
        {
          "name": "Continuous Adductor Canal Catheter (ACC)",
          "type": "DEVICE"
        },
        {
          "name": "Adductor Canal block with sham catheter",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 94,
      "start_date": "2018-11-16",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-04-28",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03747146"
    },
    {
      "nct_id": "NCT07454356",
      "title": "Knee Flexionater to Avoid Motion Restoring Surgery",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Joint Contractures",
        "Total Knee Anthroplasty",
        "Knee Arthrofibrosis"
      ],
      "interventions": [
        {
          "name": "Hydraulic high Intensity Stretch Device",
          "type": "DEVICE"
        },
        {
          "name": "Standard Physical Therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Ermi LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2025-12-09",
      "completion_date": "2029-12",
      "has_results": false,
      "last_update_posted_date": "2026-03-06",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07454356"
    },
    {
      "nct_id": "NCT00306254",
      "title": "Evaluation of PD 0348292 for Preventing Blood Clots in the Lungs or Deep Leg Veins of Patients After Knee Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Venous Thrombosis"
      ],
      "interventions": [
        {
          "name": "PD 0348292",
          "type": "DRUG"
        },
        {
          "name": "Enoxaparin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1225,
      "start_date": "2006-03",
      "completion_date": "2007-07",
      "has_results": false,
      "last_update_posted_date": "2007-10-10",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 58,
      "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • North Little Rock, Arkansas + 29 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "North Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Encinitas",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00306254"
    },
    {
      "nct_id": "NCT02251522",
      "title": "A Single Time-Point Study to Evaluate the ConforMIS iTotal® (CR) Knee Versus Off-the-Shelf",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "ConforMIS Total Knee Replacement System",
          "type": "DEVICE"
        },
        {
          "name": "Off-the-Shelf Knee Replacement System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Restor3D",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 873,
      "start_date": "2014-10",
      "completion_date": "2016-12",
      "has_results": false,
      "last_update_posted_date": "2023-10-25",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 12,
      "location_summary": "Parker, Colorado • Fort Myers, Florida • Miami, Florida + 9 more",
      "locations": [
        {
          "city": "Parker",
          "state": "Colorado"
        },
        {
          "city": "Fort Myers",
          "state": "Florida"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Port Saint Lucie",
          "state": "Florida"
        },
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02251522"
    },
    {
      "nct_id": "NCT07620145",
      "title": "Anterior Heel Wedge to Treat Flexion Contracture After Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Knee Flexion Contracture",
        "Total Knee Arthroplasty (TKA)"
      ],
      "interventions": [
        {
          "name": "Anterior heel wedge",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of North Carolina, Charlotte",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 8,
      "start_date": "2023-03-16",
      "completion_date": "2025-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-02",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 1,
      "location_summary": "Charlotte, North Carolina",
      "locations": [
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07620145"
    },
    {
      "nct_id": "NCT04712019",
      "title": "Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Surgical Wound",
        "Bilateral Total Knee Arthroplasty",
        "Wounds and Injuries",
        "Joint Diseases",
        "Musculoskeletal Diseases",
        "Edema Leg",
        "Joint Pain",
        "Arthritis Knee"
      ],
      "interventions": [
        {
          "name": "Closed Incision Negative Pressure Therapy (ciNPT)",
          "type": "DEVICE"
        },
        {
          "name": "Standard Silver-containing Dressing",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Solventum US LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2020-11-06",
      "completion_date": "2022-08-26",
      "has_results": true,
      "last_update_posted_date": "2024-10-01",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 6,
      "location_summary": "Annapolis, Maryland • Baltimore, Maryland • Columbia, Maryland + 3 more",
      "locations": [
        {
          "city": "Annapolis",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Columbia",
          "state": "Maryland"
        },
        {
          "city": "Bay Shore",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04712019"
    },
    {
      "nct_id": "NCT00487565",
      "title": "Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis",
        "Rheumatoid Arthritis",
        "Post-traumatic Arthritis",
        "Juvenile Arthritis"
      ],
      "interventions": [
        {
          "name": "Total knee arthroplasty",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "DePuy Orthopaedics",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 210,
      "start_date": "2006-09",
      "completion_date": "2011-02",
      "has_results": true,
      "last_update_posted_date": "2013-08-14",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 3,
      "location_summary": "Denver, Colorado • Pittsburgh, Pennsylvania • Virginia Beach, Virginia",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Virginia Beach",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00487565"
    },
    {
      "nct_id": "NCT01759277",
      "title": "Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Postoperative Pain Following Knee Arthroplasty"
      ],
      "interventions": [
        {
          "name": "Control: Femoral perineural local anesthetic infusion",
          "type": "DRUG"
        },
        {
          "name": "Experimental: Adductor Canal perineural local anesthetic infusion",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 80,
      "start_date": "2012-12",
      "completion_date": "2014-09",
      "has_results": true,
      "last_update_posted_date": "2021-02-18",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01759277"
    },
    {
      "nct_id": "NCT02728661",
      "title": "Patient-Centered Weight Loss Program for Knee Replacement Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "ARTHROPLASTY, REPLACEMENT"
      ],
      "interventions": [
        {
          "name": "PACE",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Delayed PACE",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "79 Years",
        "sex": "ALL",
        "summary": "40 Years to 79 Years"
      },
      "enrollment_count": 16,
      "start_date": "2016-05",
      "completion_date": "2017-06",
      "has_results": false,
      "last_update_posted_date": "2023-10-26",
      "last_synced_at": "2026-06-07T23:43:07.141Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02728661"
    }
  ]
}