{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Arthroplasties%2C+Knee+Replacement&page=17",
    "query": {
      "condition": "Arthroplasties, Knee Replacement",
      "page": 17
    },
    "page_size": 10
  },
  "pagination": {
    "page": 17,
    "page_size": 10,
    "total_count": 843,
    "total_pages": 85,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Arthroplasties%2C+Knee+Replacement&page=18&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Arthroplasties%2C+Knee+Replacement&page=16&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-15T07:20:19.967Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01844193",
      "title": "Early Postoperative Compex Rehab NMES Use for Total Knee Arthroplasty Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Compex Rehab",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Orthopaedic Research Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "45 Years to 75 Years"
      },
      "enrollment_count": 60,
      "start_date": "2013-01",
      "completion_date": "2016-12-31",
      "has_results": true,
      "last_update_posted_date": "2021-04-12",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 1,
      "location_summary": "Greenwood, Indiana",
      "locations": [
        {
          "city": "Greenwood",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01844193"
    },
    {
      "nct_id": "NCT05787821",
      "title": "Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Knee Pain Chronic",
        "Osteoarthritis, Knee",
        "Rheumatoid Arthritis",
        "Traumatic Arthritis",
        "Polyarthritis",
        "Varus Deformity",
        "Valgus Deformity",
        "Flexion Deformity of Knee",
        "Avascular Necrosis"
      ],
      "interventions": [
        {
          "name": "Total Knee Arthroplasty",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Zimmer Biomet",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 760,
      "start_date": "2023-06-28",
      "completion_date": "2035-06",
      "has_results": false,
      "last_update_posted_date": "2026-07-10",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 16,
      "location_summary": "Parker, Colorado • Tampa, Florida • Atlanta, Georgia + 13 more",
      "locations": [
        {
          "city": "Parker",
          "state": "Colorado"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05787821"
    },
    {
      "nct_id": "NCT06489626",
      "title": "The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Arthritis Knee",
        "Knee Osteoarthritis",
        "Pain, Postoperative"
      ],
      "interventions": [
        {
          "name": "Methylprednisolone 4 milligram Tab",
          "type": "DRUG"
        },
        {
          "name": "Dexamethasone injection",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "F. Johannes Plate",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2025-11-01",
      "completion_date": "2027-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-02-05",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 2,
      "location_summary": "Monroeville, Pennsylvania • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Monroeville",
          "state": "Pennsylvania"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06489626"
    },
    {
      "nct_id": "NCT07584915",
      "title": "Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Total Knee Arthroplasty",
        "Total Knee Arthroplasty Recovery"
      ],
      "interventions": [
        {
          "name": "Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA",
          "type": "PROCEDURE"
        },
        {
          "name": "Local Infiltration Analgesia (LIA)",
          "type": "PROCEDURE"
        },
        {
          "name": "Bupivacaine liposome injectable suspension (IPSA block)",
          "type": "DRUG"
        },
        {
          "name": "Bupivacaine liposome injectable suspension (LIA)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2026-06-01",
      "completion_date": "2026-08",
      "has_results": false,
      "last_update_posted_date": "2026-05-13",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07584915"
    },
    {
      "nct_id": "NCT03286543",
      "title": "Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Total Knee Replacement",
        "Total Knee Arthroplasty",
        "Pain",
        "Postoperative Pain",
        "Orthopedic Disorder"
      ],
      "interventions": [
        {
          "name": "SPRINT Beta System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "SPR Therapeutics, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "21 Years to 90 Years"
      },
      "enrollment_count": 47,
      "start_date": "2017-09-05",
      "completion_date": "2020-04-15",
      "has_results": true,
      "last_update_posted_date": "2021-05-12",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 5,
      "location_summary": "La Jolla, California • Durham, North Carolina • Cleveland, Ohio + 2 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        },
        {
          "city": "New Albany",
          "state": "Ohio"
        },
        {
          "city": "Bellaire",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03286543"
    },
    {
      "nct_id": "NCT01055015",
      "title": "Double Blind Efficacy and Safety Study of Flexible-Dose vs Low-Dose Q8003 After Undergoing Primary Unilateral Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Postoperative Pain"
      ],
      "interventions": [
        {
          "name": "Flexible dose Q8003 (morphine sulfate and oxycodone hydrochloride)",
          "type": "DRUG"
        },
        {
          "name": "Low dose Q8003 (morphine sulfate and oxycodone hydrochloride)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "QRxPharma Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 141,
      "start_date": "2010-02",
      "completion_date": "2010-12",
      "has_results": false,
      "last_update_posted_date": "2012-05-17",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 11,
      "location_summary": "Birmingham, Alabama • Sheffield, Alabama • Phoenix, Arizona + 8 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Sheffield",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "Long Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01055015"
    },
    {
      "nct_id": "NCT02434510",
      "title": "Bacterial Contamination of Operative Splash Basins",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Infection"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Utah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 111,
      "start_date": "2015-03",
      "completion_date": "2016-02",
      "has_results": false,
      "last_update_posted_date": "2016-02-29",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02434510"
    },
    {
      "nct_id": "NCT07672301",
      "title": "Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Total Knee Arthroplasty (TKA)"
      ],
      "interventions": [
        {
          "name": "Total IntraVenous Anesthesia (TIVA)",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Spinal-Block",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Electroencephalogram (EEG)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT",
        "DEVICE"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2026-03-11",
      "completion_date": "2028-06",
      "has_results": false,
      "last_update_posted_date": "2026-06-26",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07672301"
    },
    {
      "nct_id": "NCT01924403",
      "title": "Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Total Knee Arthroplasty"
      ],
      "interventions": [
        {
          "name": "Staple Closure",
          "type": "PROCEDURE"
        },
        {
          "name": "Vertical Mattress Closure",
          "type": "PROCEDURE"
        },
        {
          "name": "Running Subcuticular Closure",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2013-08",
      "completion_date": "2014-07",
      "has_results": false,
      "last_update_posted_date": "2015-02-16",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01924403"
    },
    {
      "nct_id": "NCT06426641",
      "title": "Polyethylene Wear Particle Analysis of TKA",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Wear of Articular Bearing Surface of Prosthetic Joint",
        "Total Knee Arthroplasty"
      ],
      "interventions": [
        {
          "name": "Polyethylene",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Osaka Metropolitan University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "20 Years and older"
      },
      "enrollment_count": 90,
      "start_date": "2023-12-05",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-01-17",
      "last_synced_at": "2026-10-15T07:20:19.967Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06426641"
    }
  ]
}