{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Arthroplasty+of+Knee&page=27",
    "query": {
      "condition": "Arthroplasty of Knee",
      "page": 27
    },
    "page_size": 10
  },
  "pagination": {
    "page": 27,
    "page_size": 10,
    "total_count": 872,
    "total_pages": 88,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Arthroplasty+of+Knee&page=28&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Arthroplasty+of+Knee&page=26&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-16T07:19:31.422Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02216682",
      "title": "Assessing the Efficacy of Intravenous Acetaminophen Versus the Oral Formulation for Perioperative Pain Treatment",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Postoperative Pain"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 174,
      "start_date": "2014-08",
      "completion_date": "2017-12",
      "has_results": false,
      "last_update_posted_date": "2026-06-15",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02216682"
    },
    {
      "nct_id": "NCT02620631",
      "title": "Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Acute Pain"
      ],
      "interventions": [
        {
          "name": "Morphine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stony Brook University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 54,
      "start_date": "2011-03",
      "completion_date": "2017-01",
      "has_results": false,
      "last_update_posted_date": "2015-12-03",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 1,
      "location_summary": "Stony Brook, New York",
      "locations": [
        {
          "city": "Stony Brook",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02620631"
    },
    {
      "nct_id": "NCT05593341",
      "title": "Opioid Education in Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Arthropathy of Knee",
        "Post Operative Pain",
        "Opioid Use",
        "Opioid Abuse",
        "Opioid Misuse"
      ],
      "interventions": [
        {
          "name": "Opioid education in person",
          "type": "OTHER"
        },
        {
          "name": "Opioid education via video",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 42,
      "start_date": "2022-09-27",
      "completion_date": "2023-09-11",
      "has_results": false,
      "last_update_posted_date": "2024-12-27",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05593341"
    },
    {
      "nct_id": "NCT02820766",
      "title": "Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Osteoarthritis",
        "Degenerative Arthritis",
        "Traumatic Arthritis"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Smith & Nephew, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 22,
      "start_date": "2016-09",
      "completion_date": "2017-04-27",
      "has_results": false,
      "last_update_posted_date": "2017-08-10",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 3,
      "location_summary": "Annapolis, Maryland • Eugene, Oregon • State College, Pennsylvania",
      "locations": [
        {
          "city": "Annapolis",
          "state": "Maryland"
        },
        {
          "city": "Eugene",
          "state": "Oregon"
        },
        {
          "city": "State College",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02820766"
    },
    {
      "nct_id": "NCT01081886",
      "title": "PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Degenerative Joint Disease",
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "PEAK PlasmaBlade 4.0",
          "type": "DEVICE"
        },
        {
          "name": "Traditional Electrosurgery with scalpel",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Surgical Technologies",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 24,
      "start_date": "2010-06",
      "completion_date": "2011-09",
      "has_results": true,
      "last_update_posted_date": "2013-01-08",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 2,
      "location_summary": "Rochester Hills, Michigan • Arlington, Texas",
      "locations": [
        {
          "city": "Rochester Hills",
          "state": "Michigan"
        },
        {
          "city": "Arlington",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01081886"
    },
    {
      "nct_id": "NCT05678231",
      "title": "Zero Degree Knee Positioner for Improved Earley Knee Extension Following Total Knee Arthroplasty",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "Zero Degree Knee Positioner",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Prisma Health-Midlands",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "40 Years to 80 Years"
      },
      "enrollment_count": 154,
      "start_date": "2023-02-10",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-09-18",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 1,
      "location_summary": "Columbia, South Carolina",
      "locations": [
        {
          "city": "Columbia",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05678231"
    },
    {
      "nct_id": "NCT03274466",
      "title": "Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Surgical Wound",
        "Revision Total Knee Arthroplasty",
        "Wounds and Injuries",
        "Joint Disease",
        "Musculoskeletal Disease",
        "Prosthesis-Related Infections",
        "Infection",
        "Postoperative Complications",
        "Pathologic Processes"
      ],
      "interventions": [
        {
          "name": "Closed Incision Negative Pressure Therapy (ciNPT)",
          "type": "DEVICE"
        },
        {
          "name": "Standard of Care Dressing",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "KCI USA, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 294,
      "start_date": "2017-12-05",
      "completion_date": "2019-12-19",
      "has_results": true,
      "last_update_posted_date": "2024-10-16",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 17,
      "location_summary": "Weston, Florida • Tucker, Georgia • New Orleans, Louisiana + 10 more",
      "locations": [
        {
          "city": "Weston",
          "state": "Florida"
        },
        {
          "city": "Tucker",
          "state": "Georgia"
        },
        {
          "city": "New Orleans",
          "state": "Louisiana"
        },
        {
          "city": "Columbia",
          "state": "Missouri"
        },
        {
          "city": "Bay Shore",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03274466"
    },
    {
      "nct_id": "NCT07864896",
      "title": "Suzetrigine in TKA",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Total Knee Arthroplasty (TKA)",
        "Total Knee Arthroplasty \\(TKA\\)",
        "Total Knee Replacement",
        "Total Knee Replacement Surgery",
        "Total Knee Replacements",
        "Total Knee Replacement Arthroplasty",
        "Suzetrigine",
        "Pain Management",
        "Pain",
        "Nav 1.8",
        "JOURNAVX",
        "Opioid Cessation",
        "Opioid Consumption, Postoperative",
        "Multimodal Analgesia",
        "Randomized Controlled Trial",
        "Randomized Controlled Study",
        "Randomized Controlled Trials"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "OTHER"
        },
        {
          "name": "Suzetrigine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 148,
      "start_date": "2026-10-15",
      "completion_date": "2030-01",
      "has_results": false,
      "last_update_posted_date": "2026-10-13",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07864896"
    },
    {
      "nct_id": "NCT01320150",
      "title": "Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Persistent Postsurgical Pain"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 311,
      "start_date": "2011-03",
      "completion_date": "2018-04",
      "has_results": true,
      "last_update_posted_date": "2021-09-23",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01320150"
    },
    {
      "nct_id": "NCT05765682",
      "title": "Mepivacaine Vs. Bupivacaine Spinal for TKA",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Total Knee Replacement"
      ],
      "interventions": [
        {
          "name": "Mepivacaine Spinal",
          "type": "OTHER"
        },
        {
          "name": "Bupivacaine Spinal",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 160,
      "start_date": "2023-03-13",
      "completion_date": "2024-08-25",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-10-16T07:19:31.422Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05765682"
    }
  ]
}