{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Bicuspid",
    "query": {
      "condition": "Bicuspid"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 26,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Bicuspid&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T07:38:16.804Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02889835",
      "title": "Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Supreme Universal Restorative",
          "type": "DEVICE"
        },
        {
          "name": "Supreme Flowable Restorative",
          "type": "DEVICE"
        },
        {
          "name": "Bulk Fill Flowable Restorative",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Solventum US LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "19 Years to 90 Years"
      },
      "enrollment_count": 53,
      "start_date": "2016-03-22",
      "completion_date": "2021-07-03",
      "has_results": true,
      "last_update_posted_date": "2024-10-01",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02889835"
    },
    {
      "nct_id": "NCT04149600",
      "title": "Identification of Genetic Causes of Calcific Aortic Valve Disease",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Calcific Aortic Stenosis",
        "Calcific Aortic Stenosis - Bicuspid Valve",
        "Aortic Valve Disease",
        "Aortic Valve Calcification",
        "Aortic Diseases",
        "Aortic Aneurysm",
        "Aortic Valve Cusp Abnormality",
        "Aortic Valve Disease Mixed",
        "Aortic Valve Insufficiency"
      ],
      "interventions": [
        {
          "name": "Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "20 Years and older"
      },
      "enrollment_count": 1000,
      "start_date": "2018-09-25",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-05-30",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04149600"
    },
    {
      "nct_id": "NCT03635424",
      "title": "Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bicuspid Aortic Valve"
      ],
      "interventions": [
        {
          "name": "Medtronic TAVR Systems",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Medtronic Cardiovascular",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2018-10-30",
      "completion_date": "2030-12",
      "has_results": true,
      "last_update_posted_date": "2026-05-05",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 25,
      "location_summary": "Phoenix, Arizona • La Jolla, California • Thousand Oaks, California + 21 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Thousand Oaks",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Clearwater",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03635424"
    },
    {
      "nct_id": "NCT01369108",
      "title": "Clinical Study on a New Flowable Composite as a Restorative in Adult Teeth",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Flowable composite",
          "type": "DEVICE"
        },
        {
          "name": "Conventional composite restorative",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Solventum US LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2011-01",
      "completion_date": "2013-12",
      "has_results": true,
      "last_update_posted_date": "2024-10-02",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01369108"
    },
    {
      "nct_id": "NCT07413965",
      "title": "TAVR vs SAVR in Severe Bicuspid Aortic Stenosis",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bicuspid Aortic Valve Disease"
      ],
      "interventions": [
        {
          "name": "Transcatheter Aortic Valve Replacement",
          "type": "PROCEDURE"
        },
        {
          "name": "the open chest surgery to replace the aortic valve",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 1200,
      "start_date": "2026-06-24",
      "completion_date": "2040-05-10",
      "has_results": false,
      "last_update_posted_date": "2026-05-12",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07413965"
    },
    {
      "nct_id": "NCT04226469",
      "title": "Gingival Crevicular Fluid Characterization During Orthodontic Treatment",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Healthy",
        "Maxillary First Premolar Tooth Extraction",
        "Canine Retraction"
      ],
      "interventions": [
        {
          "name": "Tooth movement",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Illinois at Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "11 Years to 35 Years"
      },
      "enrollment_count": 15,
      "start_date": "2019-01-01",
      "completion_date": "2021-05-05",
      "has_results": true,
      "last_update_posted_date": "2025-05-07",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04226469"
    },
    {
      "nct_id": "NCT01756222",
      "title": "Bicuspid Aortic Valve (BAV) Registry",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bicuspid Aortic Valve"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 5000,
      "start_date": "2010-04",
      "completion_date": "2040-12",
      "has_results": false,
      "last_update_posted_date": "2025-01-16",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01756222"
    },
    {
      "nct_id": "NCT01390181",
      "title": "The Effect of Losartan in Bicuspid Aortic Valve Patients",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bicuspid Aortic Valve",
        "Thoracic Aortic Aneurysm"
      ],
      "interventions": [
        {
          "name": "Cozaar",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 4,
      "start_date": "2011-09",
      "completion_date": "2014-01",
      "has_results": true,
      "last_update_posted_date": "2017-04-14",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01390181"
    },
    {
      "nct_id": "NCT02806310",
      "title": "Podocan and Wnt Pathway in the Development of Aortopathy in Bicuspid Valve Disease",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Aortic Valve Disease"
      ],
      "interventions": [
        {
          "name": "Blood draw",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Bassett Healthcare",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 29,
      "start_date": "2016-06",
      "completion_date": "2020-12",
      "has_results": false,
      "last_update_posted_date": "2022-03-02",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 1,
      "location_summary": "Cooperstown, New York",
      "locations": [
        {
          "city": "Cooperstown",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02806310"
    },
    {
      "nct_id": "NCT01980797",
      "title": "International Bicuspid Aortic Valve Consortium (BAVCon)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bicuspid Aortic Valve Disease",
        "Thoracic Aortic Disease in Patients With a Bicuspid Aortic Valve"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Boston University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "8 Years to 90 Years"
      },
      "enrollment_count": 6464,
      "start_date": "2013-11",
      "completion_date": "2028-11",
      "has_results": false,
      "last_update_posted_date": "2026-04-01",
      "last_synced_at": "2026-06-10T07:38:16.804Z",
      "location_count": 5,
      "location_summary": "Boston, Massachusetts • Ann Arbor, Michigan • Rochester, Minnesota + 1 more",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01980797"
    }
  ]
}