{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Bipolar+Disorder+With+Manic+or+Mixed+Episodes", "query": { "condition": "Bipolar Disorder With Manic or Mixed Episodes" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 22, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Bipolar+Disorder+With+Manic+or+Mixed+Episodes&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-06-11T02:05:15.967Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06462586", "title": "Study of Lumateperone in the Acute Treatment of Patients With Bipolar Mania", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder, Manic" ], "interventions": [ { "name": "Lumateperone", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Intra-Cellular Therapies, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 350, "start_date": "2024-06-19", "completion_date": "2026-04", "has_results": false, "last_update_posted_date": "2025-07-01", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 23, "location_summary": "Rogers, Arkansas • Bellflower, California • Culver City, California + 18 more", "locations": [ { "city": "Rogers", "state": "Arkansas" }, { "city": "Bellflower", "state": "California" }, { "city": "Culver City", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Lemon Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06462586" }, { "nct_id": "NCT03259555", "title": "A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes Associated With Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar I Disorder", "Manic Episode" ], "interventions": [ { "name": "Brexpiprazole", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 322, "start_date": "2017-09-14", "completion_date": "2019-01-02", "has_results": true, "last_update_posted_date": "2020-02-10", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 29, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Culver City, California + 23 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Culver City", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Glendale", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03259555" }, { "nct_id": "NCT00490971", "title": "A Study to Evaluate the Effectiveness and Safety of Extended-Release (ER) Paliperidone Compared With Placebo in Delaying the Recurrence of Symptoms in Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Olanzapine", "type": "DRUG" }, { "name": "Paliperidone ER", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johnson & Johnson Pharmaceutical Research & Development, L.L.C.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 768, "start_date": "2006-05", "completion_date": "2010-04", "has_results": true, "last_update_posted_date": "2015-04-15", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 16, "location_summary": "Scottsdale, Arizona • Riverside, California • San Diego, California + 13 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Riverside", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Honolulu", "state": "Hawaii" } ], "official_url": "https://clinicaltrials.gov/study/NCT00490971" }, { "nct_id": "NCT06951711", "title": "A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder Type I With Mania or Mania With Mixed Features" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 274, "start_date": "2025-06-13", "completion_date": "2026-11-02", "has_results": false, "last_update_posted_date": "2026-06-04", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 28, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Culver City, California + 23 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Culver City", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "Torrance", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06951711" }, { "nct_id": "NCT00102518", "title": "Aripiprazole Open-Label, Safety and Tolerability Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia", "Bipolar Disorder" ], "interventions": [ { "name": "Aripiprazole", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Otsuka Pharmaceutical Development & Commercialization, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "10 Years to 17 Years" }, "enrollment_count": 325, "start_date": "2004-09", "completion_date": "2007-02", "has_results": true, "last_update_posted_date": "2012-08-31", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 50, "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Costa Mesa, California + 47 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Costa Mesa", "state": "California" }, { "city": "Fresno", "state": "California" }, { "city": "Orange", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00102518" }, { "nct_id": "NCT00982020", "title": "Study in Adolescents With Schizophrenia or Bipolar Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bipolar I Disorder", "Schizophrenia" ], "interventions": [ { "name": "Olanzapine", "type": "DRUG" }, { "name": "Standard behavioral weight intervention", "type": "BEHAVIORAL" }, { "name": "Intense behavioral weight intervention", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Eli Lilly and Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "13 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "13 Years to 17 Years" }, "enrollment_count": 203, "start_date": "2009-09", "completion_date": "2013-05", "has_results": true, "last_update_posted_date": "2014-12-17", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 4, "location_summary": "Lauderhill, Florida • Bloomfield Hills, Michigan • St Louis, Missouri + 1 more", "locations": [ { "city": "Lauderhill", "state": "Florida" }, { "city": "Bloomfield Hills", "state": "Michigan" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Bellevue", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00982020" }, { "nct_id": "NCT06951698", "title": "A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar-I Disorder With Mania or Mania With Mixed Features" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 274, "start_date": "2025-06-11", "completion_date": "2026-11-01", "has_results": false, "last_update_posted_date": "2026-04-14", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 22, "location_summary": "Bentonville, Arkansas • Little Rock, Arkansas • Anaheim, California + 18 more", "locations": [ { "city": "Bentonville", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Bellflower", "state": "California" }, { "city": "Cerritos", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06951698" }, { "nct_id": "NCT04819776", "title": "Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar I Disorder" ], "interventions": [ { "name": "Iloperidone", "type": "DRUG" }, { "name": "Iloperidone Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanda Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 417, "start_date": "2021-03-22", "completion_date": "2023-08-16", "has_results": true, "last_update_posted_date": "2024-04-18", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 20, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Cerritos, California + 17 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Cerritos", "state": "California" }, { "city": "Culver City", "state": "California" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04819776" }, { "nct_id": "NCT06929273", "title": "A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder Type I With Mania" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "Lithium", "type": "DRUG" }, { "name": "Valproate", "type": "DRUG" }, { "name": "Lamotrigine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 450, "start_date": "2025-07-18", "completion_date": "2028-06-13", "has_results": false, "last_update_posted_date": "2026-06-02", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 52, "location_summary": "Glendale, Arizona • Bentonville, Arkansas • Little Rock, Arkansas + 41 more", "locations": [ { "city": "Glendale", "state": "Arizona" }, { "city": "Bentonville", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06929273" }, { "nct_id": "NCT00397020", "title": "Naturalistic Study, Comparison of Divalproex Extended Release (ER) and Quetiapine for Adults With Acute Mania or Mixed Episodes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "divalproex ER", "type": "DRUG" }, { "name": "quetiapine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, San Diego", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2006-12", "completion_date": "2008-12", "has_results": true, "last_update_posted_date": "2019-09-11", "last_synced_at": "2026-06-11T02:05:15.967Z", "location_count": 1, "location_summary": "San Diego, California", "locations": [ { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00397020" } ] }