{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Bipolar+I+Disorder%2C+Manic+or+Mixed&page=2", "query": { "condition": "Bipolar I Disorder, Manic or Mixed", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Bipolar+I+Disorder%2C+Manic+or+Mixed&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-06-10T07:51:50.406Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03573297", "title": "A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar I Disorder", "Mania", "Depression" ], "interventions": [ { "name": "Cariprazine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 901, "start_date": "2018-06-15", "completion_date": "2022-09-05", "has_results": true, "last_update_posted_date": "2023-09-28", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 46, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Anaheim, California + 39 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Anaheim", "state": "California" }, { "city": "Bellflower", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03573297" }, { "nct_id": "NCT00081380", "title": "Efficacy and Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Seroquel®, quetiapine fumarate (atypical antipsychotic)", "type": "DRUG" }, { "name": "lithium (mood stabilizer)", "type": "DRUG" }, { "name": "divalproex (mood stabilizer)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 710, "start_date": "2004-03", "completion_date": "2006-09", "has_results": false, "last_update_posted_date": "2008-12-22", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 81, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 78 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Cerritos", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00081380" }, { "nct_id": "NCT06951711", "title": "A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder Type I With Mania or Mania With Mixed Features" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 274, "start_date": "2025-06-13", "completion_date": "2026-11-02", "has_results": false, "last_update_posted_date": "2026-06-04", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 28, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Culver City, California + 23 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Culver City", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "Torrance", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06951711" }, { "nct_id": "NCT00265330", "title": "Safety and Tolerability of Ziprasidone in Children and Adolescents With Bipolar I Disorder (Manic or Mixed)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Ziprasidone oral capsules", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "10 Years to 17 Years" }, "enrollment_count": 169, "start_date": "2006-03", "completion_date": "2008-01", "has_results": true, "last_update_posted_date": "2021-03-25", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 41, "location_summary": "Scottsdale, Arizona • San Diego, California • Aurora, Colorado + 33 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Altamonte Springs", "state": "Florida" }, { "city": "Fort Lauderdale", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00265330" }, { "nct_id": "NCT02623504", "title": "DB/Maintenance of Equetro (Carbamazepine) in Children With Acute Manic or Mixed Bipolar 1 Disorder", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Carbamazepine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Validus Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "10 Years to 17 Years" }, "enrollment_count": 17, "start_date": "2016-10-24", "completion_date": "2018-11-01", "has_results": false, "last_update_posted_date": "2023-03-03", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 4, "location_summary": "Orlando, Florida • Baltimore, Maryland • St Louis, Missouri + 1 more", "locations": [ { "city": "Orlando", "state": "Florida" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02623504" }, { "nct_id": "NCT00374920", "title": "Safety and Efficacy of MEM 1003 Versus Placebo for the Treatment of Patients With Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Bipolar Disorder With Manic or Mixed Episodes" ], "interventions": [ { "name": "MEM 1003", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Memory Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 60, "start_date": "2006-09", "completion_date": "2007-03", "has_results": false, "last_update_posted_date": "2008-05-06", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 21, "location_summary": "Little Rock, Arkansas • Garden Grove, California • Riverside, California + 15 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Garden Grove", "state": "California" }, { "city": "Riverside", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Torrance", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00374920" }, { "nct_id": "NCT07288320", "title": "An Assessment of Efficacy, Safety, and Pharmacokinetics of NBI-1117568 in Adults With Bipolar I Disorder With Current Mania", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Bipolar I Disorder", "Mania" ], "interventions": [ { "name": "NBI-1117568", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Neurocrine Biosciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 150, "start_date": "2025-12-24", "completion_date": "2028-02", "has_results": false, "last_update_posted_date": "2026-03-24", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 6, "location_summary": "Garden Grove, California • Hollywood, California • San Diego, California + 3 more", "locations": [ { "city": "Garden Grove", "state": "California" }, { "city": "Hollywood", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Gaithersburg", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT07288320" }, { "nct_id": "NCT00490971", "title": "A Study to Evaluate the Effectiveness and Safety of Extended-Release (ER) Paliperidone Compared With Placebo in Delaying the Recurrence of Symptoms in Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Olanzapine", "type": "DRUG" }, { "name": "Paliperidone ER", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johnson & Johnson Pharmaceutical Research & Development, L.L.C.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 768, "start_date": "2006-05", "completion_date": "2010-04", "has_results": true, "last_update_posted_date": "2015-04-15", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 16, "location_summary": "Scottsdale, Arizona • Riverside, California • San Diego, California + 13 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Riverside", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Honolulu", "state": "Hawaii" } ], "official_url": "https://clinicaltrials.gov/study/NCT00490971" }, { "nct_id": "NCT04819776", "title": "Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar I Disorder" ], "interventions": [ { "name": "Iloperidone", "type": "DRUG" }, { "name": "Iloperidone Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanda Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 417, "start_date": "2021-03-22", "completion_date": "2023-08-16", "has_results": true, "last_update_posted_date": "2024-04-18", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 20, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Cerritos, California + 17 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Cerritos", "state": "California" }, { "city": "Culver City", "state": "California" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04819776" }, { "nct_id": "NCT00257166", "title": "Safety and Efficacy of Ziprasidone in Children and Adolescents With Bipolar I Disorder (Manic or Mixed)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Ziprasidone oral capsules", "type": "DRUG" }, { "name": "placebo oral capsules", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer's Upjohn has merged with Mylan to form Viatris Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "10 Years to 17 Years" }, "enrollment_count": 238, "start_date": "2006-01", "completion_date": "2007-07", "has_results": true, "last_update_posted_date": "2021-03-03", "last_synced_at": "2026-06-10T07:51:50.406Z", "location_count": 50, "location_summary": "Scottsdale, Arizona • Orange, California • San Diego, California + 41 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Orange", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Altamonte Springs", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00257166" } ] }