{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Bone+Substitute",
    "query": {
      "condition": "Bone Substitute"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 21,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Bone+Substitute&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-21T23:46:06.678Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06247098",
      "title": "Evaluation of Sinus Augmentation Bone Healing Using Autograft and Xenograft Compared to Xenograft Alone",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Maxillary Sinus Floor Augmentation",
        "Dental Implant",
        "Bone Substitute",
        "Autogenous Bone Graft"
      ],
      "interventions": [
        {
          "name": "Sinus Lift augmentation",
          "type": "PROCEDURE"
        },
        {
          "name": "Cone-beam computed tomography systems (CBCT)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE"
      ],
      "sponsor": "Tufts University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2024-09-01",
      "completion_date": "2028-05",
      "has_results": false,
      "last_update_posted_date": "2026-01-23",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06247098"
    },
    {
      "nct_id": "NCT04964466",
      "title": "Release Kinetics in PRF Versus GEM21S With and Without Bone Substitutes: An In Vitro Analysis",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Bone Loss"
      ],
      "interventions": [
        {
          "name": "Amount of PDGF-BB in PRF preparation vs. GEM21",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Amount of PDGF-BB available in PRF + bone substitutes vs. rhPDGF-BB+ bone substitutes following preparation",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Release kinetics of PDGF-BB in PRF + bone substitutes vs. rhPDGF-BB + bone substitutes",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Release kinetics of PDGF-BB in rhPDGF-BB + PRF + bone substitutes",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "18 Years to 99 Years"
      },
      "enrollment_count": 5,
      "start_date": "2021-08-31",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-02",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04964466"
    },
    {
      "nct_id": "NCT00974623",
      "title": "Bone Graft Materials Observational Registry",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Degenerative Disc Disease",
        "Herniated Disc",
        "Spinal Stenosis",
        "Spondylolithesis",
        "Spinal Deformity",
        "Cervical Myelopathy",
        "Failed Back Surgery Syndrome",
        "Spinal Cord Neoplasms"
      ],
      "interventions": [
        {
          "name": "Bone graft substitute, autograft or allograft",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Baxter Healthcare Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 329,
      "start_date": "2009-09",
      "completion_date": "2013-11",
      "has_results": false,
      "last_update_posted_date": "2017-04-05",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 12,
      "location_summary": "San Francisco, California • Atlanta, Georgia • Carrollton, Georgia + 9 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Carrollton",
          "state": "Georgia"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Worcester",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00974623"
    },
    {
      "nct_id": "NCT05405374",
      "title": "OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lumbar Spine Disease",
        "Lumbar Spondylolisthesis",
        "Lumbar Spine Instability",
        "Lumbar Spondylosis",
        "Degenerative Disc Disease"
      ],
      "interventions": [
        {
          "name": "OSTEOAMP",
          "type": "OTHER"
        },
        {
          "name": "Infuse",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE"
      ],
      "sponsor": "Bioventus LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "21 Years to 80 Years"
      },
      "enrollment_count": 101,
      "start_date": "2022-05-06",
      "completion_date": "2025-10",
      "has_results": false,
      "last_update_posted_date": "2023-08-28",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 9,
      "location_summary": "New Haven, Connecticut • Wichita, Kansas • Paducah, Kentucky + 6 more",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Wichita",
          "state": "Kansas"
        },
        {
          "city": "Paducah",
          "state": "Kentucky"
        },
        {
          "city": "Shreveport",
          "state": "Louisiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05405374"
    },
    {
      "nct_id": "NCT03494660",
      "title": "SCP Hip Outcomes Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Subchondral Cysts",
        "Subchondral Bone Edema",
        "Bone Marrow Edema",
        "Insufficiency Fractures",
        "Avascular Necrosis of Hip",
        "Femoroacetabular Impingement",
        "Dysplasia; Hip"
      ],
      "interventions": [
        {
          "name": "Subchondroplasty Procedure with AccuFill",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Zimmer Biomet",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 77,
      "start_date": "2018-03-27",
      "completion_date": "2025-01-13",
      "has_results": true,
      "last_update_posted_date": "2026-04-21",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 6,
      "location_summary": "Rancho Mirage, California • Gulf Breeze, Florida • Rockford, Illinois + 3 more",
      "locations": [
        {
          "city": "Rancho Mirage",
          "state": "California"
        },
        {
          "city": "Gulf Breeze",
          "state": "Florida"
        },
        {
          "city": "Rockford",
          "state": "Illinois"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03494660"
    },
    {
      "nct_id": "NCT01728844",
      "title": "GUIDOR® Growth Factor Enhanced Bone Graft Substitute for the Treatment of Periodontal Defects 6-months Post-Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alveolar Bone Loss",
        "Periodontal Diseases"
      ],
      "interventions": [
        {
          "name": "beta-tricalcium phosphate alone",
          "type": "DEVICE"
        },
        {
          "name": "GFeBGS 0.1%",
          "type": "DEVICE"
        },
        {
          "name": "GFeBGS 0.3%",
          "type": "DEVICE"
        },
        {
          "name": "GFeBGS 0.4%",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Sunstar Americas",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "25 Years and older"
      },
      "enrollment_count": 88,
      "start_date": "2012-10",
      "completion_date": "2014-08",
      "has_results": true,
      "last_update_posted_date": "2020-09-17",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 6,
      "location_summary": "Birmingham, Alabama • Fullerton, California • Aurora, Colorado + 3 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Fullerton",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01728844"
    },
    {
      "nct_id": "NCT04433117",
      "title": "Bone Material Comparison in Maxillary Sinus Augmentation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Alveolar Bone Resorption",
        "Sequela",
        "Tooth Extrusion"
      ],
      "interventions": [
        {
          "name": "Shefabone",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Bio-Oss",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Mohanad Al-Sabbagh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "20 Years to 75 Years"
      },
      "enrollment_count": 24,
      "start_date": "2020-06-17",
      "completion_date": "2023-03-01",
      "has_results": true,
      "last_update_posted_date": "2024-03-21",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04433117"
    },
    {
      "nct_id": "NCT03087396",
      "title": "A Longitudinal Outcomes Study of the Subchondroplasty® Procedure in the Foot/Ankle",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Insufficiency Fractures",
        "Stress Fracture",
        "Stress Fracture, Ankle, Foot and Toes"
      ],
      "interventions": [
        {
          "name": "Treatment of insufficiency fractures",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Zimmer Biomet",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 148,
      "start_date": "2017-03-10",
      "completion_date": "2023-08-23",
      "has_results": true,
      "last_update_posted_date": "2026-04-09",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 11,
      "location_summary": "Mesa, Arizona • Sun City, Arizona • Capitola, California + 8 more",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Sun City",
          "state": "Arizona"
        },
        {
          "city": "Capitola",
          "state": "California"
        },
        {
          "city": "Rancho Mirage",
          "state": "California"
        },
        {
          "city": "Redwood City",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03087396"
    },
    {
      "nct_id": "NCT01359488",
      "title": "VRS-317 in Adult Subjects With Growth Hormone Deficiency",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Growth Hormone Deficiency"
      ],
      "interventions": [
        {
          "name": "VRS-317",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Versartis Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "25 Years to 65 Years"
      },
      "enrollment_count": 50,
      "start_date": "2011-03",
      "completion_date": "2012-07",
      "has_results": false,
      "last_update_posted_date": "2012-07-23",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01359488"
    },
    {
      "nct_id": "NCT06720142",
      "title": "Mg OSTEOCRETE Post-Treatment Outcomes",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cancer of Bone",
        "Trauma",
        "Aseptic Loosening of Orthopaedic Hardware"
      ],
      "interventions": [
        {
          "name": "Mg OSTEOCRETE as a bone void filler",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Santiago Lozano-Calderon",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2025-03-17",
      "completion_date": "2028-03-17",
      "has_results": false,
      "last_update_posted_date": "2026-04-22",
      "last_synced_at": "2026-07-21T23:46:06.678Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06720142"
    }
  ]
}