{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Brain+Injuries%2C+Acute&page=2",
    "query": {
      "condition": "Brain Injuries, Acute",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Brain+Injuries%2C+Acute&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T19:28:00.073Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00955877",
      "title": "Extended-release Epidural Morphine for Acute Post-operative Analgesia Following Selective Dorsal Rhizotomy in Children",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spastic Cerebral Palsy"
      ],
      "interventions": [
        {
          "name": "Extended-release Epidural morphine (EREM) 80",
          "type": "DRUG"
        },
        {
          "name": "Extended-release Epidural Morphine (EREM) 120",
          "type": "DRUG"
        },
        {
          "name": "Control: Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "2 Years to 12 Years"
      },
      "enrollment_count": 13,
      "start_date": "2010-03",
      "completion_date": "2015-01",
      "has_results": true,
      "last_update_posted_date": "2018-07-11",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00955877"
    },
    {
      "nct_id": "NCT05469139",
      "title": "Assessing Brain Injury Using Portable Magnetic Resonance Imaging (MRI)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Extracorporeal Membrane Oxygenation Complication",
        "Acute Brain Injury"
      ],
      "interventions": [
        {
          "name": "Portable MRI acquisition",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2021-12-10",
      "completion_date": "2024-03-11",
      "has_results": false,
      "last_update_posted_date": "2024-03-13",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland • Houston, Texas",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05469139"
    },
    {
      "nct_id": "NCT03345550",
      "title": "OPTIMA-TBI Pilot Study",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Mild Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "Omega-3 Polyunsaturated Fatty Acids (Fish Oil 1000 mg (contains 500 mg DHA & 100 mg EPA)) or placebo capsules.",
          "type": "DRUG"
        },
        {
          "name": "Placebo - Cap",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 44,
      "start_date": "2017-09-12",
      "completion_date": "2021-07-27",
      "has_results": true,
      "last_update_posted_date": "2023-05-23",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03345550"
    },
    {
      "nct_id": "NCT04935697",
      "title": "Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome",
        "Acute Lung Injury",
        "Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)",
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "nVNS",
          "type": "DEVICE"
        },
        {
          "name": "SOC",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "12 Years to 80 Years"
      },
      "enrollment_count": 3,
      "start_date": "2021-08-04",
      "completion_date": "2025-03-01",
      "has_results": true,
      "last_update_posted_date": "2026-05-29",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04935697"
    },
    {
      "nct_id": "NCT03277859",
      "title": "Strength and Awareness in Action: an Intervention for Post-Acute TBI Headaches (SAA-TBI)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury",
        "Post-concussive Headaches"
      ],
      "interventions": [
        {
          "name": "SAA-TBI",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Eastern Colorado Health Care System",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 75,
      "start_date": "2017-08-16",
      "completion_date": "2019-06-30",
      "has_results": false,
      "last_update_posted_date": "2019-07-23",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03277859"
    },
    {
      "nct_id": "NCT06469801",
      "title": "ECMO ABI Detection With Hyperfine",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Brain Injury",
        "Extracorporeal Membrane Oxygenation Complication",
        "Hypoxia-Ischemia, Brain",
        "Stroke, Acute"
      ],
      "interventions": [
        {
          "name": "Hyperfine",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Children's Mercy Hospital Kansas City",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "0 Days",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "0 Days to 17 Years"
      },
      "enrollment_count": 30,
      "start_date": "2024-07-23",
      "completion_date": "2026-07-01",
      "has_results": false,
      "last_update_posted_date": "2025-08-15",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 1,
      "location_summary": "Kansas City, Missouri",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06469801"
    },
    {
      "nct_id": "NCT07331324",
      "title": "The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Caregiver Distress",
        "Emotional Distress",
        "Caregivers",
        "Resilience",
        "Coma",
        "Brain Injury"
      ],
      "interventions": [
        {
          "name": "Coma Family Program 1",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Coma Family Program 2",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2026-05",
      "completion_date": "2030-12",
      "has_results": false,
      "last_update_posted_date": "2026-02-20",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 3,
      "location_summary": "Baltimore, Maryland • Boston, Massachusetts • Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07331324"
    },
    {
      "nct_id": "NCT03287557",
      "title": "Dysregulated CNS Inflammation After Acute Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Traumatic Brain Injury",
        "Aneurysmal Subarachnoid Hemorrhage"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Kentucky",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "101 Years",
        "sex": "ALL",
        "summary": "18 Years to 101 Years"
      },
      "enrollment_count": 8,
      "start_date": "2018-01-02",
      "completion_date": "2019-05-24",
      "has_results": false,
      "last_update_posted_date": "2019-08-29",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03287557"
    },
    {
      "nct_id": "NCT02174016",
      "title": "The Ketogenic Diet for Pediatric Acute Brain Injury",
      "overall_status": "SUSPENDED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Brain Injuries"
      ],
      "interventions": [
        {
          "name": "Ketogenic diet",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "1 Year to 17 Years"
      },
      "enrollment_count": 5,
      "start_date": "2015-01",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02174016"
    },
    {
      "nct_id": "NCT04820192",
      "title": "Craniosacral Therapy for Concussion Symptoms",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Post-Concussion Syndrome"
      ],
      "interventions": [
        {
          "name": "Craniosacral Therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Special Therapies, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "14 Years to 90 Years"
      },
      "enrollment_count": 67,
      "start_date": "2018-01-15",
      "completion_date": "2019-07-30",
      "has_results": false,
      "last_update_posted_date": "2021-03-29",
      "last_synced_at": "2026-06-10T19:28:00.073Z",
      "location_count": 1,
      "location_summary": "Waukesha, Wisconsin",
      "locations": [
        {
          "city": "Waukesha",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04820192"
    }
  ]
}