{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Buprenorphine+Withdrawal+Syndrome",
    "query": {
      "condition": "Buprenorphine Withdrawal Syndrome"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 15,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Buprenorphine+Withdrawal+Syndrome&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T08:13:48.202Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02363998",
      "title": "Open-Label, Safety Study of Lofexidine",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Opioid Withdrawal"
      ],
      "interventions": [
        {
          "name": "Lofexidine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "USWM, LLC (dba US WorldMeds)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 286,
      "start_date": "2015-02",
      "completion_date": "2015-10",
      "has_results": true,
      "last_update_posted_date": "2022-03-22",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 18,
      "location_summary": "Little Rock, Arkansas • Springdale, Arkansas • San Diego, California + 15 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Springdale",
          "state": "Arkansas"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Fort Lauderdale",
          "state": "Florida"
        },
        {
          "city": "Hollywood",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02363998"
    },
    {
      "nct_id": "NCT01820442",
      "title": "Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Opioid Dependence",
        "Buprenorphine Withdrawal Syndrome"
      ],
      "interventions": [
        {
          "name": "Lofexidine HCl",
          "type": "DRUG"
        },
        {
          "name": "Lofexidine-matching sugar pill",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "USWM, LLC (dba US WorldMeds)",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 30,
      "start_date": "2013-03",
      "completion_date": "2013-09",
      "has_results": false,
      "last_update_posted_date": "2018-02-23",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01820442"
    },
    {
      "nct_id": "NCT04850664",
      "title": "Computerized Chemosensory-Based Orbitofrontal Cortex (CBOT) for Opioid Use Disorder",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Opioid Use Disorder, Moderate",
        "Opioid Use Disorder, Severe",
        "Withdrawal Symptoms",
        "Craving",
        "Negative Affectivity"
      ],
      "interventions": [
        {
          "name": "CBOT + TAU",
          "type": "DRUG"
        },
        {
          "name": "Sham + TAU",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Evon Medics LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 190,
      "start_date": "2021-03-26",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2021-08-06",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 4,
      "location_summary": "Washington D.C., District of Columbia • Rockville, Maryland",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Rockville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04850664"
    },
    {
      "nct_id": "NCT00032955",
      "title": "Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Heroin Dependence",
        "Morphine Dependence",
        "Substance Withdrawal Syndrome"
      ],
      "interventions": [
        {
          "name": "Buprenorphine/naloxone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "15 Years and older"
      },
      "enrollment_count": 163,
      "start_date": "2001-02",
      "completion_date": "2002-08",
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 6,
      "location_summary": "Rancho Mirage, California • Orlando, Florida • Pinellas Park, Florida + 3 more",
      "locations": [
        {
          "city": "Rancho Mirage",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Pinellas Park",
          "state": "Florida"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00032955"
    },
    {
      "nct_id": "NCT00032968",
      "title": "Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Heroin Dependence",
        "Morphine Dependence",
        "Substance Withdrawal Syndrome"
      ],
      "interventions": [
        {
          "name": "Buprenorphine/naloxone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "15 Years and older"
      },
      "enrollment_count": 341,
      "start_date": "2001-01",
      "completion_date": "2002-08",
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 7,
      "location_summary": "Berkeley, California • Oxnard, California • Indianapolis, Indiana + 4 more",
      "locations": [
        {
          "city": "Berkeley",
          "state": "California"
        },
        {
          "city": "Oxnard",
          "state": "California"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Piscataway",
          "state": "New Jersey"
        },
        {
          "city": "Brooklyn",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00032968"
    },
    {
      "nct_id": "NCT01708707",
      "title": "Comparison of Buprenorphine to Morphine in Treatment of Neonatal Abstinence Syndrome (NAS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Neonatal Abstinence Syndrome",
        "Neonatal Withdrawal Syndrome"
      ],
      "interventions": [
        {
          "name": "Buprenorphine",
          "type": "DRUG"
        },
        {
          "name": "Morphine Sulfate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pediatrix",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "1 Year",
        "sex": "ALL",
        "summary": "Up to 1 Year"
      },
      "enrollment_count": 29,
      "start_date": "2012-12",
      "completion_date": "2017-10-31",
      "has_results": false,
      "last_update_posted_date": "2018-08-15",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 1,
      "location_summary": "Phoenix, Arizona",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01708707"
    },
    {
      "nct_id": "NCT03911466",
      "title": "Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Opioid-Related Disorders",
        "Drug Addiction",
        "Pregnancy Related",
        "Substance Abuse",
        "Drug Abuse",
        "Neonatal Abstinence Syndrome",
        "Neonatal Opioid Withdrawal Syndrome",
        "Drug Abuse in Pregnancy"
      ],
      "interventions": [
        {
          "name": "Buprenorphine Injection",
          "type": "DRUG"
        },
        {
          "name": "Buprenorphine Sublingual Product",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "T. John Winhusen, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "41 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 41 Years · Female only"
      },
      "enrollment_count": 97,
      "start_date": "2020-07-21",
      "completion_date": "2024-11-06",
      "has_results": false,
      "last_update_posted_date": "2026-03-16",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 12,
      "location_summary": "Jacksonville, Florida • Boston, Massachusetts • Albuquerque, New Mexico + 8 more",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03911466"
    },
    {
      "nct_id": "NCT00521248",
      "title": "Buprenorphine for the Treatment of Neonatal Abstinence Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Neonatal Abstinence Syndrome"
      ],
      "interventions": [
        {
          "name": "buprenorphine",
          "type": "DRUG"
        },
        {
          "name": "Oral morphine solution",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 60,
      "start_date": "2004-04",
      "completion_date": "2010-01",
      "has_results": false,
      "last_update_posted_date": "2017-01-12",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00521248"
    },
    {
      "nct_id": "NCT03608696",
      "title": "Buprenorphine Pharmacometric Open Label Research Study of Drug Exposure",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Neonatal Abstinence Syndrome",
        "Neonatal Opiate Withdrawal Syndrome"
      ],
      "interventions": [
        {
          "name": "Buprenorphine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "4 Weeks",
        "sex": "ALL",
        "summary": "Up to 4 Weeks"
      },
      "enrollment_count": 10,
      "start_date": "2018-08-29",
      "completion_date": "2019-07-11",
      "has_results": true,
      "last_update_posted_date": "2022-02-11",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03608696"
    },
    {
      "nct_id": "NCT03918850",
      "title": "Medication Treatment for Opioid Use Disorder in Expectant Mothers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Drug Addiction",
        "Pregnancy Related",
        "Substance Abuse",
        "Drug Abuse",
        "Neonatal Abstinence Syndrome",
        "Neonatal Opioid Withdrawal Syndrome",
        "Drug Abuse in Pregnancy"
      ],
      "interventions": [
        {
          "name": "Buprenorphine Injection",
          "type": "DRUG"
        },
        {
          "name": "Buprenorphine Sublingual Product",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "T. John Winhusen, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "41 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 41 Years · Female only"
      },
      "enrollment_count": 140,
      "start_date": "2020-07-21",
      "completion_date": "2025-01-31",
      "has_results": false,
      "last_update_posted_date": "2025-06-27",
      "last_synced_at": "2026-05-22T08:13:48.202Z",
      "location_count": 12,
      "location_summary": "Jacksonville, Florida • Boston, Massachusetts • Albuquerque, New Mexico + 8 more",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Albuquerque",
          "state": "New Mexico"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03918850"
    }
  ]
}