{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=C1+Esterase+Inhibitor%2C+Deficiency+of&page=2", "query": { "condition": "C1 Esterase Inhibitor, Deficiency of", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=C1+Esterase+Inhibitor%2C+Deficiency+of&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-06-10T18:14:43.411Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06960213", "title": "STOP-HAE: A Phase 3 Study of ADX-324 in HAE", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema", "HAE", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2" ], "interventions": [ { "name": "ADX-324", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "ADARx Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 90, "start_date": "2025-08-28", "completion_date": "2027-12-31", "has_results": false, "last_update_posted_date": "2026-05-18", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 15, "location_summary": "Litchfield Park, Arizona • Little Rock, Arkansas • San Diego, California + 12 more", "locations": [ { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Orlando", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06960213" }, { "nct_id": "NCT01095510", "title": "CINRYZE for the Treatment of Hereditary Angioedema Attacks in Children Under the Age of 12", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hereditary Angioedema (HAE)" ], "interventions": [ { "name": "CINRYZE", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "11 Years", "sex": "ALL", "summary": "2 Years to 11 Years" }, "enrollment_count": 9, "start_date": "2010-06-02", "completion_date": "2012-04-17", "has_results": true, "last_update_posted_date": "2021-06-03", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 8, "location_summary": "Colorado Springs, Colorado • Tampa, Florida • Chevy Chase, Maryland + 5 more", "locations": [ { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Tampa", "state": "Florida" }, { "city": "Chevy Chase", "state": "Maryland" }, { "city": "Eugene", "state": "Oregon" }, { "city": "Lake Oswego", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT01095510" }, { "nct_id": "NCT04656418", "title": "CSL312 (Garadacimab) in the Prevention of Hereditary Angioedema Attacks", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "CSL312", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "CSL Behring", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 64, "start_date": "2021-01-27", "completion_date": "2022-06-07", "has_results": true, "last_update_posted_date": "2023-06-29", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 8, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Santa Monica, California + 5 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Santa Monica", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Chevy Chase", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04656418" }, { "nct_id": "NCT00262080", "title": "Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema (HAE)" ], "interventions": [ { "name": "ecallantide", "type": "DRUG" }, { "name": "Phosphate Buffer Saline (PBS),", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": null, "sex": "ALL", "summary": "10 Years and older" }, "enrollment_count": 91, "start_date": "2005-12-31", "completion_date": "2007-02-28", "has_results": true, "last_update_posted_date": "2021-06-11", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 1, "location_summary": "Wheaton, Maryland", "locations": [ { "city": "Wheaton", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00262080" }, { "nct_id": "NCT01059526", "title": "Observational Safety Study for KALBITOR (Ecallantide) in the Treatment of Acute Attacks of Hereditary Angioedema", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Hereditary Angioedema (HAE)" ], "interventions": [ { "name": "ecallantide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "ALL", "summary": "16 Years and older" }, "enrollment_count": 81, "start_date": "2010-02-01", "completion_date": "2014-06-01", "has_results": true, "last_update_posted_date": "2021-06-08", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 40, "location_summary": "Little Rock, Arkansas • Bell Gardens, California • Granada Hills, California + 35 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Bell Gardens", "state": "California" }, { "city": "Granada Hills", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Orange", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01059526" }, { "nct_id": "NCT05396105", "title": "Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Hereditary Angioedema", "Hereditary Angioedema Type I", "Hereditary Angioedema Type II", "Hereditary Angioedema Types I and II", "Hereditary Angioedema Attack", "Hereditary Angioedema With C1 Esterase Inhibitor Deficiency", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "Hereditary Angioedema - Type 3", "C1 Esterase Inhibitor [C1-INH] Deficiency", "C1 Esterase Inhibitor Deficiency", "C1 Esterase Inhibitor, Deficiency of", "C1 Inhibitor Deficiency", "Hereditary Angioedema Type III", "Hereditary Angioedema (HAE)", "Hereditary Angioedema Type I and II" ], "interventions": [ { "name": "deucrictibant", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pharvaris Netherlands B.V.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 150, "start_date": "2022-12-28", "completion_date": "2027-06", "has_results": false, "last_update_posted_date": "2026-03-16", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 13, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 10 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05396105" }, { "nct_id": "NCT05819775", "title": "CSL312_3003 Safety and Pharmacokinetic Study in Subjects 2 to 11 Years of Age With Hereditary Angioedema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema (HAE)" ], "interventions": [ { "name": "CSL312", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "CSL Behring", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "11 Years", "sex": "ALL", "summary": "2 Years to 11 Years" }, "enrollment_count": 22, "start_date": "2023-05-30", "completion_date": "2025-11-19", "has_results": true, "last_update_posted_date": "2026-06-02", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 7, "location_summary": "Litchfield Park, Arizona • Scottsdale, Arizona • Orange, California + 4 more", "locations": [ { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Orange", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "Cincinnati", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT05819775" }, { "nct_id": "NCT04739059", "title": "Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "CSL312", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "CSL Behring", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 171, "start_date": "2021-03-29", "completion_date": "2025-11-21", "has_results": true, "last_update_posted_date": "2026-06-02", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 11, "location_summary": "Birmingham, Alabama • Litchfield Park, Arizona • Scottsdale, Arizona + 8 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Orange", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04739059" }, { "nct_id": "NCT00168103", "title": "Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) Attacks", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "C1 Esterase Inhibitor", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "CSL Behring", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": null, "sex": "ALL", "summary": "6 Years and older" }, "enrollment_count": 126, "start_date": "2005-06", "completion_date": "2007-12", "has_results": true, "last_update_posted_date": "2015-03-31", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 17, "location_summary": "Granada Hills, California • Weston, Florida • Atlanta, Georgia + 14 more", "locations": [ { "city": "Granada Hills", "state": "California" }, { "city": "Weston", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Idaho Falls", "state": "Idaho" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT00168103" }, { "nct_id": "NCT02052141", "title": "Safety and Efficacy Study of CINRYZE for Prevention of Angioedema Attacks in Children Ages 6-11 With Hereditary Angioedema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema (HAE)" ], "interventions": [ { "name": "CINRYZE 500", "type": "BIOLOGICAL" }, { "name": "CINRYZE 1000", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "11 Years", "sex": "ALL", "summary": "6 Years to 11 Years" }, "enrollment_count": 12, "start_date": "2014-03-20", "completion_date": "2017-05-04", "has_results": true, "last_update_posted_date": "2021-06-03", "last_synced_at": "2026-06-10T18:14:43.411Z", "location_count": 3, "location_summary": "Colorado Springs, Colorado • Las Vegas, Nevada • Eugene, Oregon", "locations": [ { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Las Vegas", "state": "Nevada" }, { "city": "Eugene", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT02052141" } ] }