{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=C1+Esterase+Inhibitor+Deficiency&page=4", "query": { "condition": "C1 Esterase Inhibitor Deficiency", "page": 4 }, "page_size": 10 }, "pagination": { "page": 4, "page_size": 10, "total_count": 88, "total_pages": 9, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=C1+Esterase+Inhibitor+Deficiency&page=5&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=C1+Esterase+Inhibitor+Deficiency&page=3&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-08T12:28:46.101Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06343779", "title": "Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema", "Hereditary Angioedema Type I", "Hereditary Angioedema Type II", "Hereditary Angioedema Types I and II", "Hereditary Angioedema Attack", "Hereditary Angioedema With C1 Esterase Inhibitor Deficiency", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "C1 Esterase Inhibitor [C1-INH] Deficiency", "C1 Esterase Inhibitor Deficiency", "C1 Esterase Inhibitor, Deficiency of", "C1 Inhibitor Deficiency", "Hereditary Angioedema - Type 3", "Hereditary Angioedema Type III" ], "interventions": [ { "name": "Deucrictibant, Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pharvaris Netherlands B.V.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "12 Years to 75 Years" }, "enrollment_count": 134, "start_date": "2024-02-26", "completion_date": "2025-10-17", "has_results": false, "last_update_posted_date": "2025-11-21", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 13, "location_summary": "Birmingham, Alabama • Paradise Valley, Arizona • Little Rock, Arkansas + 10 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Paradise Valley", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06343779" }, { "nct_id": "NCT03472040", "title": "A Long Term Safety Study of BCX7353 in Hereditary Angioedema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Hereditary Angioedema", "HAE", "Prophylaxis" ], "interventions": [ { "name": "BCX7353", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "BioCryst Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 387, "start_date": "2018-02-16", "completion_date": "2022-04-27", "has_results": true, "last_update_posted_date": "2023-06-18", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 42, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Bentonville, Arkansas + 39 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Bentonville", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03472040" }, { "nct_id": "NCT06960213", "title": "STOP-HAE: A Phase 3 Study of ADX-324 in HAE", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema", "HAE", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2" ], "interventions": [ { "name": "ADX-324", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "ADARx Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 90, "start_date": "2025-08-28", "completion_date": "2027-12-31", "has_results": false, "last_update_posted_date": "2026-09-10", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 19, "location_summary": "Litchfield Park, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 16 more", "locations": [ { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06960213" }, { "nct_id": "NCT00432510", "title": "Pharmacokinetics of C1 Esterase Inhibitor in Hereditary Angioedema Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "C1 esterase inhibitor [human] (C1INH-nf)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 27, "start_date": "2006-10-09", "completion_date": "2007-02-28", "has_results": false, "last_update_posted_date": "2021-06-03", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 6, "location_summary": "San Diego, California • Walnut Creek, California • Atlanta, Georgia + 3 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Wheaton", "state": "Maryland" }, { "city": "Hershey", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00432510" }, { "nct_id": "NCT05121376", "title": "A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Hereditary Angioedema", "HAE" ], "interventions": [ { "name": "Dose 1 of BMN 331", "type": "GENETIC" }, { "name": "Dose 2 of BMN 331", "type": "GENETIC" }, { "name": "Dose 3 of BMN 331", "type": "GENETIC" }, { "name": "Dose 4 of BMN 331", "type": "GENETIC" }, { "name": "Dose 5 of BMN 331", "type": "GENETIC" }, { "name": "Dose 6 of BMN 331", "type": "GENETIC" }, { "name": "Dose 7 of BMN 331", "type": "GENETIC" } ], "intervention_types": [ "GENETIC" ], "sponsor": "BioMarin Pharmaceutical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 44, "start_date": "2022-02-15", "completion_date": "2028-11", "has_results": false, "last_update_posted_date": "2024-05-16", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 13, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • San Diego, California + 10 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05121376" }, { "nct_id": "NCT01095497", "title": "A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CINRYZE Administration", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "CINRYZE", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Shire", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 26, "start_date": "2010-06-07", "completion_date": "2010-12-16", "has_results": true, "last_update_posted_date": "2021-07-09", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 7, "location_summary": "Scottsdale, Arizona • Walnut Creek, California • Atlanta, Georgia + 4 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Chevy Chase", "state": "Maryland" }, { "city": "Lake Oswego", "state": "Oregon" } ], "official_url": "https://clinicaltrials.gov/study/NCT01095497" }, { "nct_id": "NCT03576469", "title": "A Study to Evaluate the Benefit of RUCONEST® in Subjects Who Experience ADRs Related to IVIG Infusions", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "CVI - Common Variable Immunodeficiency" ], "interventions": [ { "name": "C1-esterase inhibitor [recombinant] (C1-INH-R)", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "IMMUNOe Research Centers", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2018-06-13", "completion_date": "2020-03-01", "has_results": false, "last_update_posted_date": "2021-02-15", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 1, "location_summary": "Centennial, Colorado", "locations": [ { "city": "Centennial", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT03576469" }, { "nct_id": "NCT07428499", "title": "Phase 3 Extension Study of ADX-324 in Participants With Hereditary Angioedema (HAE)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema (HAE)", "Hereditary Angioedema - Type 1", "Hereditary Angioedema - Type 2", "HAE" ], "interventions": [ { "name": "ADX-324 Dose Level 1", "type": "DRUG" }, { "name": "ADX-324 Dose Level 2", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "ADARx Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 90, "start_date": "2026-04-02", "completion_date": "2030-06-30", "has_results": false, "last_update_posted_date": "2026-09-04", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 15, "location_summary": "Litchfield Park, Arizona • Little Rock, Arkansas • San Diego, California + 12 more", "locations": [ { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Orlando", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07428499" }, { "nct_id": "NCT06467084", "title": "Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema" ], "interventions": [ { "name": "KVD900 150 mg", "type": "DRUG" }, { "name": "KVD900 300 mg", "type": "DRUG" }, { "name": "KVD900 600 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "KalVista Pharmaceuticals, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "11 Years", "sex": "ALL", "summary": "2 Years to 11 Years" }, "enrollment_count": 36, "start_date": "2024-08-01", "completion_date": "2026-01-15", "has_results": true, "last_update_posted_date": "2026-08-05", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 10, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • San Diego, California + 7 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "Evansville", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT06467084" }, { "nct_id": "NCT03485911", "title": "Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAE", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hereditary Angioedema", "HAE" ], "interventions": [ { "name": "BCX7353 capsules", "type": "DRUG" }, { "name": "Placebo oral capsule", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "BioCryst Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": null, "sex": "ALL", "summary": "12 Years and older" }, "enrollment_count": 121, "start_date": "2018-02-06", "completion_date": "2022-04-06", "has_results": true, "last_update_posted_date": "2023-06-26", "last_synced_at": "2026-10-08T12:28:46.101Z", "location_count": 27, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 24 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "San Diego", "state": "California" }, { "city": "Santa Monica", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03485911" } ] }