{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=CADASIL", "query": { "condition": "CADASIL" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 13, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=CADASIL&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-05-22T04:37:43.410Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05677880", "title": "Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "CADASIL" ], "interventions": [ { "name": "Study Procedures", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "University of Wisconsin, Madison", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 660, "start_date": "2022-06-03", "completion_date": "2027-08", "has_results": false, "last_update_posted_date": "2026-01-15", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 12, "location_summary": "Los Angeles, California • San Francisco, California • Denver, Colorado + 9 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT05677880" }, { "nct_id": "NCT03047369", "title": "The Myelin Disorders Biorepository Project", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Leukodystrophy", "White Matter Disease", "Leukoencephalopathies", "4H Syndrome", "Adrenoleukodystrophy", "AMN", "ALD", "ALD Gene Mutation", "ALD (Adrenoleukodystrophy)", "X-linked Adrenoleukodystrophy", "X-ALD", "Adrenomyeloneuropathy", "Aicardi Goutieres Syndrome", "AGS", "Alexander Disease", "Alexanders Leukodystrophy", "AxD", "ADLD", "Canavan Disease", "CTX", "Cerebrotendinous Xanthomatoses", "Krabbe Disease", "GALC Deficiency", "Globoid Leukodystrophy", "TUBB4A-Related Leukodystrophy", "H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum", "HBSL", "HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity", "LBSL", "Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)", "Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation", "ALSP", "CSF1R Gene Mutation", "HCC - Hypomyelination and Congenital Cataract", "MLC1", "Megalencephalic Leukoencephalopathy With Subcortical Cysts", "MLD", "Metachromatic Leukodystrophy", "PMD", "Pelizaeus-Merzbacher Disease", "PLP1 Null Syndrome", "PLP1 Gene Duplication | Blood or Tissue | Mutations", "Pelizaeus Merzbacher Like Disease", "Peroxisomal Biogenesis Disorder", "Zellweger Syndrome", "Refsum Disease", "Salla Disease", "Sialic Storage Disease", "Sjögren", "Sjogren-Larsson Syndrome", "Van Der Knapp Disease", "Vanishing White Matter Disease", "Charcot-Marie-Tooth", "CMT", "Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency", "Allan-Herndon-Dudley Syndrome", "Cadasil", "Cockayne Syndrome", "Multiple Sulfatase Deficiency", "Gangliosidoses", "GM2 Gangliosidosis", "BPAN", "Labrune Syndrome", "LCC", "Mucopolysaccharidoses", "TBCK-Related Intellectual Disability Syndrome" ], "interventions": [], "intervention_types": [], "sponsor": "Children's Hospital of Philadelphia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 12000, "start_date": "2016-12-08", "completion_date": "2030-12-08", "has_results": false, "last_update_posted_date": "2025-10-23", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 23, "location_summary": "Los Angeles, California • Orange, California • Palo Alto, California + 18 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Sacramento", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03047369" }, { "nct_id": "NCT05491980", "title": "Florida Cerebrovascular Disease Biorepository and Genomics Center", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Cerebrovascular Disease", "Ischemic Stroke", "Transient Ischemic Attack", "Intracerebral Hemorrhage", "Aneurysmal Subarachnoid Hemorrhage", "Vascular Dementia", "Anoxic Brain Injury", "Unruptured Intracranial Aneurysm", "Carotid Artery Stenosis Symptomatic", "Asymptomatic Carotid Artery Stenosis", "Non-Aneurysmal Perimesencephalic Subarachnoid Haemorrhage", "Cerebral Venous Thrombosis", "Moyamoya Disease", "Fibromuscular Dysplasia", "Subarachnoid Hemorrhage", "Leukoaraiosis", "Arteriovenous Fistula", "Reversible Cerebral Vasoconstriction Syndrome", "CADASIL" ], "interventions": [], "intervention_types": [], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 72, "start_date": "2022-08-02", "completion_date": "2026-06", "has_results": false, "last_update_posted_date": "2026-05-13", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 1, "location_summary": "Jacksonville, Florida", "locations": [ { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05491980" }, { "nct_id": "NCT00103948", "title": "The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Cognitive Impairment" ], "interventions": [ { "name": "Aricept", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eisai Limited", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "25 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "25 Years to 70 Years" }, "enrollment_count": 165, "start_date": "2005-02", "completion_date": "2007-02", "has_results": false, "last_update_posted_date": "2015-11-03", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 2, "location_summary": "Maywood, Illinois • New York, New York", "locations": [ { "city": "Maywood", "state": "Illinois" }, { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00103948" }, { "nct_id": "NCT04753970", "title": "Retina is a Marker for Cerebrovascular Heath", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Cerebral Small Vessel Diseases", "Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy", "Cerebral Microbleeding", "Sporadic White Matter Disease" ], "interventions": [ { "name": "Cilostazol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 100, "start_date": "2021-02-09", "completion_date": "2026-06", "has_results": false, "last_update_posted_date": "2025-07-23", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 1, "location_summary": "Jacksonville, Florida", "locations": [ { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04753970" }, { "nct_id": "NCT03724136", "title": "Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Alzheimer Disease", "Alzheimer Dementia", "Vascular Dementia", "Lewy Body Disease", "Lewy Body Dementia With Behavioral Disturbance (Disorder)", "Dementia, Mixed", "Parkinson-Dementia Syndrome", "Chronic Traumatic Encephalopathy", "Huntington's Dementia", "Wernicke Korsakoff Syndrome", "Traumatic Brain Injury", "Dementia, Multi-Infarct", "Autism", "Autism Spectrum Disorder", "Autistic Behavior", "Autistic Disorder, Current or Active State", "Cadasil", "LATE Limbic-predominant Age-related TDP-43 Encephalopathy" ], "interventions": [ { "name": "Intravenous Bone Marrow Stem Cell (BMSC) Fraction", "type": "PROCEDURE" }, { "name": "Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction", "type": "PROCEDURE" }, { "name": "Near Infrared Light", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "MD Stem Cells", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 100, "start_date": "2018-10-24", "completion_date": "2025-07-31", "has_results": false, "last_update_posted_date": "2024-04-15", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 2, "location_summary": "Westport, Connecticut • Coral Springs, Florida", "locations": [ { "city": "Westport", "state": "Connecticut" }, { "city": "Coral Springs", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03724136" }, { "nct_id": "NCT05072483", "title": "Natural History Study of CADASIL", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Cardiovascular Disease", "Arterial Stiffness", "Germline Mutation in the NOTCH 3 Gene", "Pathogenesis of CADASIL", "Clinical Phenotype of CADASIL" ], "interventions": [ { "name": "MRI", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 155, "start_date": "2022-04-18", "completion_date": "2041-06-01", "has_results": false, "last_update_posted_date": "2026-05-14", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT05072483" }, { "nct_id": "NCT02795052", "title": "Neurologic Stem Cell Treatment Study", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Neurologic Disorders", "Nervous System Diseases", "Neurodegenerative Diseases", "Neurological Disorders", "Stroke", "Traumatic Brain Injury", "Cadasil", "Chronic Traumatic Encephalopathy", "Cerebral Infarction", "Cerebral Ischemia", "Cerebral Stroke", "Cerebral Hemorrhage", "Parkinson", "Multi-System Degeneration", "MSA - Multiple System Atrophy", "Progressive Supranuclear Palsy", "ALS", "Amyotrophic Lateral Sclerosis", "Neuropathy", "Diabetic Neuropathies", "Alzheimer Disease", "Dementia", "Frontotemporal Dementia", "Lewy Body Disease", "Cognitive Impairment", "Lewy Body Variant of Alzheimer Disease" ], "interventions": [ { "name": "Intravenous and Intranasal BMSC", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "MD Stem Cells", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 500, "start_date": "2016-06", "completion_date": "2027-07-31", "has_results": false, "last_update_posted_date": "2025-06-06", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 2, "location_summary": "Westport, Connecticut • Coral Springs, Florida", "locations": [ { "city": "Westport", "state": "Connecticut" }, { "city": "Coral Springs", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT02795052" }, { "nct_id": "NCT02821780", "title": "CADASIL Disease Discovery", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Germline Mutation in the NOTCH 3 Gene", "Cardiovascular Disease", "Arterial Stiffness", "Pathogenesis of CADASIL", "Clinical Phenotype of CADASIL" ], "interventions": [], "intervention_types": [], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 20, "start_date": "2016-10-18", "completion_date": "2022-05-03", "has_results": false, "last_update_posted_date": "2026-04-14", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 2, "location_summary": "Bethesda, Maryland • Columbus, Ohio", "locations": [ { "city": "Bethesda", "state": "Maryland" }, { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT02821780" }, { "nct_id": "NCT02699190", "title": "LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Leukodystrophy", "White Matter Disease", "4H Syndrome", "Adrenoleukodystrophy", "AMN", "ALD", "ALD (Adrenoleukodystrophy)", "X-linked Adrenoleukodystrophy", "X-ALD", "Adrenomyeloneuropathy", "Aicardi Goutieres Syndrome", "AGS", "Alexander Disease", "Alexanders Leukodystrophy", "AxD", "ADLD", "Canavan Disease", "CTX", "Cerebrotendinous Xanthomatoses", "Krabbe Disease", "GALC Deficiency", "Globoid Leukodystrophy", "TUBB4A-Related Leukodystrophy", "H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum", "HBSL", "HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity", "LBSL", "Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)", "Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation", "ALSP", "CSF1R Gene Mutation", "HCC - Hypomyelination and Congenital Cataract", "MLC1", "Megalencephalic Leukoencephalopathy With Subcortical Cysts 1", "MLD", "Metachromatic Leukodystrophy", "PMD", "Pelizaeus-Merzbacher Disease", "PLP1 Null Syndrome", "PLP1 Gene Duplication | Blood or Tissue | Mutations", "Pelizaeus-Merzbacher-Like Disease, 1", "Peroxisomal Biogenesis Disorder", "Zellweger Syndrome", "Refsum Disease", "Salla Disease", "Sialic Storage Disease", "Sjögren", "Sjogren-Larsson Syndrome", "Van Der Knapp Disease", "Vanishing White Matter Disease", "Charcot-Marie-Tooth", "CMT", "Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency", "Allan-Herndon-Dudley Syndrome", "Cadasil", "Cockayne Syndrome", "Multiple Sulfatase Deficiency", "Gangliosidoses", "GM2 Gangliosidosis", "BPAN", "Labrune Syndrome", "LCC", "Mucopolysaccharidoses", "TBCK-Related Intellectual Disability Syndrome" ], "interventions": [], "intervention_types": [], "sponsor": "Children's Hospital of Philadelphia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "18 Years", "sex": "ALL", "summary": "Up to 18 Years" }, "enrollment_count": 236, "start_date": "2017-01-06", "completion_date": "2024-10-31", "has_results": true, "last_update_posted_date": "2025-11-10", "last_synced_at": "2026-05-22T04:37:43.410Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT02699190" } ] }