{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=CLN2",
    "query": {
      "condition": "CLN2"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 13,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=CLN2&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T14:03:47.522Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01161576",
      "title": "Safety Study of a Gene Transfer Vector (Rh.10) for Children With Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Batten Disease",
        "Late-Infantile Neuronal Ceroid Lipofuscinosis"
      ],
      "interventions": [
        {
          "name": "AAVrh.10CUhCLN2 vector 9.0x10^11 genome copies",
          "type": "BIOLOGICAL"
        },
        {
          "name": "AAVrh.10CUhCLN2 vector 2.85x10^11 genome copies",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "2 Years to 18 Years"
      },
      "enrollment_count": 12,
      "start_date": "2010-08-19",
      "completion_date": "2020-12-31",
      "has_results": false,
      "last_update_posted_date": "2021-02-02",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01161576"
    },
    {
      "nct_id": "NCT02963350",
      "title": "A Multicenter, Multi-national Open-label Program to Provide BMN 190 to Patients Diagnosed With CLN2 Disease",
      "overall_status": "APPROVED_FOR_MARKETING",
      "study_type": "EXPANDED_ACCESS",
      "phases": [],
      "conditions": [
        "CLN2 Disease"
      ],
      "interventions": [
        {
          "name": "BMN190, recombinant human tripeptidyl peptidase-1 (rhTPP1)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "BioMarin Pharmaceutical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "2 Years and older"
      },
      "enrollment_count": null,
      "start_date": null,
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2017-07-24",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 2,
      "location_summary": "Orange, California • Columbus, Ohio",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02963350"
    },
    {
      "nct_id": "NCT01414985",
      "title": "AAVRh.10 Administered to Children With Late Infantile Neuronal Ceroid Lipofuscinosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Late Infantile Neuronal Ceroid Lipofuscinosis",
        "Batten Disease"
      ],
      "interventions": [
        {
          "name": "AAVrh.10CUCLN2",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "3 Years to 18 Years"
      },
      "enrollment_count": 8,
      "start_date": "2010-04-15",
      "completion_date": "2017-02-08",
      "has_results": false,
      "last_update_posted_date": "2020-08-31",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01414985"
    },
    {
      "nct_id": "NCT04476862",
      "title": "Cerliponase Alfa Observational Study in the US",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Late-Infantile Neuronal Ceroid Lipofuscinosis Type 2"
      ],
      "interventions": [
        {
          "name": "Cerliponase Alfa",
          "type": "DRUG"
        },
        {
          "name": "Administration Kit",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "BioMarin Pharmaceutical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 35,
      "start_date": "2020-08-19",
      "completion_date": "2030-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-30",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 16,
      "location_summary": "Little Rock, Arkansas • Orange, California • Aurora, Colorado + 12 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04476862"
    },
    {
      "nct_id": "NCT00337636",
      "title": "Study of HuCNS-SC Cells in Patients With Infantile or Late Infantile Neuronal Ceroid Lipofuscinosis (NCL)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Neuronal Ceroid Lipofuscinosis"
      ],
      "interventions": [
        {
          "name": "Surgery to implant human CNS stem cells (HuCNS-SC)",
          "type": "PROCEDURE"
        },
        {
          "name": "Medication to suppress the immune system",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "StemCells, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Months",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "18 Months to 12 Years"
      },
      "enrollment_count": 6,
      "start_date": "2006-05",
      "completion_date": "2009-09",
      "has_results": false,
      "last_update_posted_date": "2015-01-15",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00337636"
    },
    {
      "nct_id": "NCT05152914",
      "title": "Intravitreal ERT to Prevent Retinal Disease Progression in Children With CLN2",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Neuronal Ceroid Lipofuscinosis Type 2"
      ],
      "interventions": [
        {
          "name": "Cerliponase Alfa",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "David L Rogers, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "24 Months",
        "maximum_age": "72 Months",
        "sex": "ALL",
        "summary": "24 Months to 72 Months"
      },
      "enrollment_count": 5,
      "start_date": "2021-11-01",
      "completion_date": "2027-03-06",
      "has_results": false,
      "last_update_posted_date": "2026-04-30",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05152914"
    },
    {
      "nct_id": "NCT01907087",
      "title": "A Phase 1/2 Open-Label Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Efficacy of Intracerebroventricular BMN 190 in Patients With Late-Infantile Neuronal Ceroid Lipofuscinosis (CLN2) Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Jansky-Bielschowsky Disease",
        "Batten Disease",
        "Late-Infantile Neuronal Ceroid Lipofuscinosis Type 2",
        "CLN2 Disease"
      ],
      "interventions": [
        {
          "name": "BMN 190",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "BioMarin Pharmaceutical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "15 Years",
        "sex": "ALL",
        "summary": "3 Years to 15 Years"
      },
      "enrollment_count": 24,
      "start_date": "2013-09",
      "completion_date": "2015-11",
      "has_results": true,
      "last_update_posted_date": "2019-03-08",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01907087"
    },
    {
      "nct_id": "NCT04098211",
      "title": "Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Neuronal Ceroid-Lipofuscinoses",
        "Neuronal Ceroid Lipofuscinosis CLN2",
        "Spinocerebellar Ataxia, Autosomal Recessive 7"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Children's Hospital of Orange County",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "4 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "4 Years and older"
      },
      "enrollment_count": 5,
      "start_date": "2019-11-01",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-04-08",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 1,
      "location_summary": "Orange, California",
      "locations": [
        {
          "city": "Orange",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04098211"
    },
    {
      "nct_id": "NCT02485899",
      "title": "An Extension Study to Evaluate the Long-Term Efficacy and Safety of BMN 190 in Patients With CLN2 Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Jansky-Bielschowsky Disease",
        "Batten Disease",
        "Late-Infantile Neuronal Ceroid Lipofuscinosis Type 2",
        "CLN2 Disease",
        "CLN2 Disorder"
      ],
      "interventions": [
        {
          "name": "BMN 190",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Intracerebroventricular (ICV) access device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "DEVICE"
      ],
      "sponsor": "BioMarin Pharmaceutical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "16 Years",
        "sex": "ALL",
        "summary": "3 Years to 16 Years"
      },
      "enrollment_count": 23,
      "start_date": "2015-02",
      "completion_date": "2020-12-10",
      "has_results": true,
      "last_update_posted_date": "2022-08-24",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02485899"
    },
    {
      "nct_id": "NCT03862274",
      "title": "Examining Developmental Outcomes of Children Diagnosed With CLN2 Disease",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Batten Disease",
        "CLN2",
        "Neuronal Ceroid-Lipofuscinoses"
      ],
      "interventions": [
        {
          "name": "CLN2 Treatment",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Jessica Scherr",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 30,
      "start_date": "2018-12-01",
      "completion_date": "2025-12",
      "has_results": false,
      "last_update_posted_date": "2025-10-24",
      "last_synced_at": "2026-07-22T14:03:47.522Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03862274"
    }
  ]
}