{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=COPD+Acute+Exacerbation",
    "query": {
      "condition": "COPD Acute Exacerbation"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 48,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=COPD+Acute+Exacerbation&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T14:25:51.039Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03255057",
      "title": "Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPD",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Exacerbation of COPD"
      ],
      "interventions": [
        {
          "name": "Hemolung Respiratory Assist System",
          "type": "DEVICE"
        },
        {
          "name": "Invasive mechanical ventilation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Alung Technologies",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 113,
      "start_date": "2018-02-18",
      "completion_date": "2022-08-17",
      "has_results": false,
      "last_update_posted_date": "2022-10-14",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 32,
      "location_summary": "Sacramento, California • Denver, Colorado • Newark, Delaware + 28 more",
      "locations": [
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03255057"
    },
    {
      "nct_id": "NCT03214458",
      "title": "Effects of Nasal High-flow Oxygen in Patients With an Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Obstructive Pulmonary Disease"
      ],
      "interventions": [
        {
          "name": "Nasal high flow",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Temple University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2017-07-20",
      "completion_date": "2018-04-18",
      "has_results": false,
      "last_update_posted_date": "2018-04-19",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03214458"
    },
    {
      "nct_id": "NCT06801964",
      "title": "AECOPD and Nutritional Supplementation in COPD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obstructive Pulmonary Disease",
        "Exacerbation Copd"
      ],
      "interventions": [
        {
          "name": "Stable isotope infusion",
          "type": "OTHER"
        },
        {
          "name": "Protein and Fish Oil",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Protein and Olive Oil",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Carbohydrate and Olive Oil",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Texas A&M University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "45 Years and older"
      },
      "enrollment_count": 5,
      "start_date": "2017-10-20",
      "completion_date": "2019-01-08",
      "has_results": false,
      "last_update_posted_date": "2025-01-30",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 1,
      "location_summary": "College Station, Texas",
      "locations": [
        {
          "city": "College Station",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06801964"
    },
    {
      "nct_id": "NCT01663987",
      "title": "Investigate the Impact of Early Treatment Initiation With Tiotropium in Patients Recovering From Hospitalization for an Acute COPD Exacerbation 1",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pulmonary Disease, Chronic Obstructive"
      ],
      "interventions": [
        {
          "name": "tiotropium bromide",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Boehringer Ingelheim",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 79,
      "start_date": "2012-08-01",
      "completion_date": "2014-05-01",
      "has_results": true,
      "last_update_posted_date": "2018-10-17",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 49,
      "location_summary": "Birmingham, Alabama • Florence, Alabama • Fountain Valley, California + 44 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Florence",
          "state": "Alabama"
        },
        {
          "city": "Fountain Valley",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01663987"
    },
    {
      "nct_id": "NCT06461403",
      "title": "Inhaler Trainer Efficacy Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Asthma",
        "Copd",
        "Acute Exacerbation of COPD"
      ],
      "interventions": [
        {
          "name": "Inhaler Trainer System",
          "type": "DEVICE"
        },
        {
          "name": "Initial Inhaler Use Assessment",
          "type": "OTHER"
        },
        {
          "name": "Inhaler Use Instruction",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Koronis Biomedical Technologies",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 10,
      "start_date": "2025-10-09",
      "completion_date": "2026-04-28",
      "has_results": false,
      "last_update_posted_date": "2026-06-08",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06461403"
    },
    {
      "nct_id": "NCT04821869",
      "title": "ProAir Digihaler in COPD Disease Management: A Real World Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "COPD",
        "COPD Exacerbation Acute"
      ],
      "interventions": [
        {
          "name": "ProAir Digihaler",
          "type": "DRUG"
        },
        {
          "name": "Digihaler",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Pulmonary Research Institute of Southeast Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "45 Years and older"
      },
      "enrollment_count": 27,
      "start_date": "2021-05-10",
      "completion_date": "2022-06-21",
      "has_results": true,
      "last_update_posted_date": "2025-06-13",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 1,
      "location_summary": "Farmington Hills, Michigan",
      "locations": [
        {
          "city": "Farmington Hills",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04821869"
    },
    {
      "nct_id": "NCT05182294",
      "title": "Tolerance and Acute Effects of a New HFNT Nasal Cannula",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "COPD Exacerbation Acute"
      ],
      "interventions": [
        {
          "name": "AIRVO 2, the new asymmetric nasal cannula",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Temple University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 14,
      "start_date": "2022-05-25",
      "completion_date": "2023-01-31",
      "has_results": false,
      "last_update_posted_date": "2023-04-06",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05182294"
    },
    {
      "nct_id": "NCT03110614",
      "title": "Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chronic Obstructive Pulmonary Disease",
        "Diastolic Dysfunction"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 94,
      "start_date": "2013-11-25",
      "completion_date": "2021-08-30",
      "has_results": false,
      "last_update_posted_date": "2021-10-19",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03110614"
    },
    {
      "nct_id": "NCT02135744",
      "title": "Pre-Discharge Bundle for Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease to Reduce Readmissions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Obstructive Pulmonary Disease",
        "Exacerbation of Chronic Obstructive Pulmonary Disease"
      ],
      "interventions": [
        {
          "name": "Bundle tool",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Henry Ford Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "99 Years",
        "sex": "ALL",
        "summary": "40 Years to 99 Years"
      },
      "enrollment_count": 172,
      "start_date": "2010-02",
      "completion_date": "2013-04",
      "has_results": false,
      "last_update_posted_date": "2024-01-18",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02135744"
    },
    {
      "nct_id": "NCT03094806",
      "title": "Vibratory PEP Device and Hospital Length of Stay for Acute Exacerbation of COPD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Obstructive Pulmonary Disease"
      ],
      "interventions": [
        {
          "name": "Acapella Vibratory PEP Therapy Device plus usual care",
          "type": "DEVICE"
        },
        {
          "name": "Sham Acapella Vibratory PEP Device plus usual care",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "New York Presbyterian Brooklyn Methodist Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 91,
      "start_date": "2013-10",
      "completion_date": "2015-12",
      "has_results": true,
      "last_update_posted_date": "2024-03-21",
      "last_synced_at": "2026-06-26T14:25:51.039Z",
      "location_count": 1,
      "location_summary": "Brooklyn, New York",
      "locations": [
        {
          "city": "Brooklyn",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03094806"
    }
  ]
}