{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Carbon+Dioxide",
    "query": {
      "condition": "Carbon Dioxide"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 166,
    "total_pages": 17,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Carbon+Dioxide&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T02:53:20.038Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01743872",
      "title": "Optical Imaging Measurement of Intravascular Solution Efficacy Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Peripheral Artery Disease"
      ],
      "interventions": [
        {
          "name": "Contrast Injection",
          "type": "PROCEDURE"
        },
        {
          "name": "Dextran Injection",
          "type": "PROCEDURE"
        },
        {
          "name": "CO2 Injection",
          "type": "PROCEDURE"
        },
        {
          "name": "Heparinized Normal Saline Injection",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University Hospitals Cleveland Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 23,
      "start_date": "2012-09",
      "completion_date": "2016-06",
      "has_results": true,
      "last_update_posted_date": "2022-09-21",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01743872"
    },
    {
      "nct_id": "NCT00685386",
      "title": "A Randomized Controlled Trial (RCT) of Carbon Dioxide Versus Air Insufflation During Endoscopic Retrograde Cholangiopancreatography (ERCP)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cholestasis"
      ],
      "interventions": [
        {
          "name": "CO2 insufflation",
          "type": "OTHER"
        },
        {
          "name": "Room air insufflation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 74,
      "start_date": "2008-06",
      "completion_date": "2009-02",
      "has_results": false,
      "last_update_posted_date": "2013-01-24",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 1,
      "location_summary": "Chapel Hill, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00685386"
    },
    {
      "nct_id": "NCT00638755",
      "title": "The Effect of Nasal Carbon Dioxide (CO2) on Nasal Congestion in Subjects With Perennial Allergic Rhinitis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Perennial Allergic Rhinitis"
      ],
      "interventions": [
        {
          "name": "Nasal Carbon Dioxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Capnia, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "19 Years to 65 Years"
      },
      "enrollment_count": 20,
      "start_date": "2008-02",
      "completion_date": "2008-07",
      "has_results": false,
      "last_update_posted_date": "2010-08-19",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 1,
      "location_summary": "Omaha, Nebraska",
      "locations": [
        {
          "city": "Omaha",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00638755"
    },
    {
      "nct_id": "NCT01477177",
      "title": "Polar Wand Carbon Dioxide Cryotherapy for Barrett's Esophagus",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Barrett's Esophagus"
      ],
      "interventions": [
        {
          "name": "Polar Wand carbon dioxide cryotherapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Mayo Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "98 Years",
        "sex": "ALL",
        "summary": "18 Years to 98 Years"
      },
      "enrollment_count": 4,
      "start_date": "2011-08",
      "completion_date": "2014-04",
      "has_results": true,
      "last_update_posted_date": "2019-05-15",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01477177"
    },
    {
      "nct_id": "NCT02114164",
      "title": "Study of Carbon Dioxide Exchange Patterns During Robotic Prostatectomies",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prostate Cancer",
        "Pneumoperitoneum"
      ],
      "interventions": [
        {
          "name": "AirSeal System",
          "type": "DEVICE"
        },
        {
          "name": "Standard Endopath",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "OhioHealth",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "MALE",
        "summary": "18 Years and older · Male only"
      },
      "enrollment_count": 109,
      "start_date": "2016-08",
      "completion_date": "2019-07-15",
      "has_results": true,
      "last_update_posted_date": "2021-11-26",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02114164"
    },
    {
      "nct_id": "NCT02929667",
      "title": "Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Epilepsy",
        "SUDEP"
      ],
      "interventions": [
        {
          "name": "Fluoxetine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rup Kamal Sainju",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 30,
      "start_date": "2017-02-16",
      "completion_date": "2019-03-06",
      "has_results": true,
      "last_update_posted_date": "2020-05-04",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 2,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        },
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02929667"
    },
    {
      "nct_id": "NCT03306628",
      "title": "Early Carbon Dioxide Laser Therapy for Alleviation of Incisional Scar Burden",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Skin Scarring"
      ],
      "interventions": [
        {
          "name": "CO2 Laser Administration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "NYU Langone Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "80 Years",
        "sex": "FEMALE",
        "summary": "21 Years to 80 Years · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2017-11-15",
      "completion_date": "2019-08-26",
      "has_results": false,
      "last_update_posted_date": "2020-01-06",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03306628"
    },
    {
      "nct_id": "NCT02896036",
      "title": "Veress Entry With/Without Concomitant CO2",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Laparoscopy",
        "Laparoscopic Surgery",
        "Insufflation",
        "Gynecologic Surgical Procedures"
      ],
      "interventions": [
        {
          "name": "Veress needle entry with concomitant CO2",
          "type": "PROCEDURE"
        },
        {
          "name": "Veress needle entry with subsequent CO2",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of South Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 70 Years · Female only"
      },
      "enrollment_count": 100,
      "start_date": "2016-08",
      "completion_date": "2018-03-10",
      "has_results": false,
      "last_update_posted_date": "2018-03-30",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02896036"
    },
    {
      "nct_id": "NCT03287687",
      "title": "Safety and Efficacy of CO2 for Endoscopy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Endoscopy",
        "Insufflation"
      ],
      "interventions": [
        {
          "name": "Carbon dioxide (CO2) gas insufflation",
          "type": "DRUG"
        },
        {
          "name": "Air insufflation",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Warren Bishop",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Months",
        "maximum_age": "21 Years",
        "sex": "ALL",
        "summary": "6 Months to 21 Years"
      },
      "enrollment_count": 180,
      "start_date": "2017-11-27",
      "completion_date": "2019-04-09",
      "has_results": true,
      "last_update_posted_date": "2022-01-19",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03287687"
    },
    {
      "nct_id": "NCT00273377",
      "title": "The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Surgical Wound Infection",
        "Surgery, Colon"
      ],
      "interventions": [
        {
          "name": "Mild intraoperative hypercapnia (50 mmHg vs. 30 mmHg)",
          "type": "OTHER"
        },
        {
          "name": "Supplemental oxygen (80% vs. 30%)",
          "type": "OTHER"
        },
        {
          "name": "Dexamethasone",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 2000,
      "start_date": "2002-05",
      "completion_date": "2007-12",
      "has_results": false,
      "last_update_posted_date": "2016-06-29",
      "last_synced_at": "2026-05-22T02:53:20.038Z",
      "location_count": 2,
      "location_summary": "Louisville, Kentucky • Cleveland, Ohio",
      "locations": [
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00273377"
    }
  ]
}