{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Center-involved+Diabetic+Macular+Edema&page=2", "query": { "condition": "Center-involved Diabetic Macular Edema", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Center-involved+Diabetic+Macular+Edema&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-06-10T21:45:53.952Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04503551", "title": "A Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Macular Edema To Evaluate the Efficacy, Safety, and Pharmacokinetics of Ranibizumab Delivered Via the Port Delivery System Relative to the Comparator Arm", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetic Retinopathy" ], "interventions": [ { "name": "PDS Implant Pre-Filled with 100 mg/mL Ranibizumab", "type": "DRUG" }, { "name": "Intravitreal Ranibizumab 0.5 mg Injection", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 174, "start_date": "2020-08-10", "completion_date": "2026-02-23", "has_results": true, "last_update_posted_date": "2026-04-02", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 64, "location_summary": "Mesa, Arizona • Phoenix, Arizona • Bakersfield, California + 59 more", "locations": [ { "city": "Mesa", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Bakersfield", "state": "California" }, { "city": "Encino", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04503551" }, { "nct_id": "NCT02448446", "title": "The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Center Involved Edema and Lipid Exudates", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Diabetic Macular Edema", "Hard Lipid Exudates" ], "interventions": [ { "name": "ranibizumab 0.3mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "South Coast Retina Center; Carson, McBeath, Boswell, Inc.", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 25, "start_date": "2015-08", "completion_date": "2018-05", "has_results": true, "last_update_posted_date": "2021-07-08", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 4, "location_summary": "Huntington Beach, California • Long Beach, California • Santa Monica, California + 1 more", "locations": [ { "city": "Huntington Beach", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Santa Monica", "state": "California" }, { "city": "Torrance", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02448446" }, { "nct_id": "NCT02699450", "title": "A Study of Faricimab (RO6867461) in Participants With Center-Involving Diabetic Macular Edema", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetic Macular Edema" ], "interventions": [ { "name": "Faricimab", "type": "DRUG" }, { "name": "Ranibizumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 229, "start_date": "2016-04-27", "completion_date": "2017-12-14", "has_results": true, "last_update_posted_date": "2020-09-25", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 60, "location_summary": "Phoenix, Arizona • Tucson, Arizona • Fullerton, California + 53 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Fullerton", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02699450" }, { "nct_id": "NCT05296447", "title": "Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Diabetic Retinopathy, DR" ], "interventions": [ { "name": "No Intervention", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 100, "start_date": "2022-04-04", "completion_date": "2028-05", "has_results": false, "last_update_posted_date": "2025-06-18", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 19, "location_summary": "Phoenix, Arizona • Bakersfield, California • Beverly Hills, California + 16 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Bakersfield", "state": "California" }, { "city": "Beverly Hills", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Mountain View", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05296447" }, { "nct_id": "NCT07553429", "title": "A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Diabetic Macular Edema" ], "interventions": [ { "name": "Low dose BI 3812465", "type": "BIOLOGICAL" }, { "name": "Medium dose BI 3812465", "type": "BIOLOGICAL" }, { "name": "High dose BI 3812465", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Boehringer Ingelheim", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 49, "start_date": "2026-05-14", "completion_date": "2027-07-06", "has_results": false, "last_update_posted_date": "2026-06-03", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 29, "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Arcadia, California + 25 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Arcadia", "state": "California" }, { "city": "Bakersfield", "state": "California" }, { "city": "Beverly Hills", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07553429" }, { "nct_id": "NCT07592273", "title": "Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Diabetic Retinopathy" ], "interventions": [ { "name": "Surabgene Lomparvovec", "type": "DRUG" }, { "name": "Sham", "type": "DRUG" }, { "name": "Topical Steroid", "type": "DRUG" }, { "name": "Artificial Tears", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 576, "start_date": "2026-05-20", "completion_date": "2036-01", "has_results": false, "last_update_posted_date": "2026-06-04", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 3, "location_summary": "Mountain View, California • Oak Forest, Illinois • Austin, Texas", "locations": [ { "city": "Mountain View", "state": "California" }, { "city": "Oak Forest", "state": "Illinois" }, { "city": "Austin", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT07592273" }, { "nct_id": "NCT03466099", "title": "Study of the Intravitreal Plasma Kallikrein Inhibitor, KVD001, in Subjects With Center-involving Diabetic Macular Edema (ciDME)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetic Macular Edema" ], "interventions": [ { "name": "KVD001 Injection", "type": "DRUG" }, { "name": "Sham Procedure", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "KalVista Pharmaceuticals, Ltd.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 129, "start_date": "2018-02-16", "completion_date": "2019-10-10", "has_results": true, "last_update_posted_date": "2021-01-28", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 35, "location_summary": "Phoenix, Arizona • Tucson, Arizona • Arcadia, California + 28 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Arcadia", "state": "California" }, { "city": "Beverly Hills", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03466099" }, { "nct_id": "NCT01331005", "title": "NSAID Phase II for Non-central Involved Diabetic Macular Edema (DME)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetic Macular Edema" ], "interventions": [ { "name": "nepafenac 0.1% drops", "type": "DRUG" }, { "name": "Nepafenac Vehicle", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Jaeb Center for Health Research", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 125, "start_date": "2011-05", "completion_date": "2013-12", "has_results": true, "last_update_posted_date": "2025-03-10", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 32, "location_summary": "Loma Linda, California • Palm Springs, California • Santa Barbara, California + 29 more", "locations": [ { "city": "Loma Linda", "state": "California" }, { "city": "Palm Springs", "state": "California" }, { "city": "Santa Barbara", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Westlake Village", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01331005" }, { "nct_id": "NCT03866005", "title": "Prospective Study of Adjunctive Carotenoids Plus Anti-oxidants in Anti-VEGF Treated Diabetic Macular Edema", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Center-involved Diabetic Macular Edema (CI-DME)" ], "interventions": [ { "name": "Diabetes Visual Function Study (DiVFuSS) softgels", "type": "DIETARY_SUPPLEMENT" }, { "name": "canola oil placebo softgels, 2 per day", "type": "OTHER" } ], "intervention_types": [ "DIETARY_SUPPLEMENT", "OTHER" ], "sponsor": "ZeaVision, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 150, "start_date": "2019-11-01", "completion_date": "2021-11-01", "has_results": false, "last_update_posted_date": "2020-07-02", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 2, "location_summary": "Olympia, Washington • Tacoma, Washington", "locations": [ { "city": "Olympia", "state": "Washington" }, { "city": "Tacoma", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT03866005" }, { "nct_id": "NCT07118670", "title": "High Dose Eylea for Proliferative Diabetic Retinopathy Outcomes", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Proliferative Diabetic Retinopathy (PDR)" ], "interventions": [ { "name": "Aflibercept 8mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Edward Wood, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2025-12-08", "completion_date": "2028-04", "has_results": false, "last_update_posted_date": "2026-03-18", "last_synced_at": "2026-06-10T21:45:53.952Z", "location_count": 3, "location_summary": "Austin, Texas • Bellaire, Texas • San Antonio, Texas", "locations": [ { "city": "Austin", "state": "Texas" }, { "city": "Bellaire", "state": "Texas" }, { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT07118670" } ] }