{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Anomalies&page=63", "query": { "condition": "Central Nervous System Anomalies", "page": 63 }, "page_size": 10 }, "pagination": { "page": 63, "page_size": 10, "total_count": 1712, "total_pages": 172, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Anomalies&page=64&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Anomalies&page=62&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-24T15:58:24.540Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04229017", "title": "Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel DDD", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Degenerative Disc Disease" ], "interventions": [ { "name": "Anterior Cervical Discectomy and Fusion", "type": "PROCEDURE" }, { "name": "Posterior Cervical Stabilization System (PCSS)", "type": "DEVICE" } ], "intervention_types": [ "PROCEDURE", "DEVICE" ], "sponsor": "Providence Medical Technology, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 236, "start_date": "2020-03-18", "completion_date": "2025-12", "has_results": false, "last_update_posted_date": "2025-10-30", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 17, "location_summary": "Phoenix, Arizona • Encinitas, California • Los Gatos, California + 14 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Encinitas", "state": "California" }, { "city": "Los Gatos", "state": "California" }, { "city": "Durango", "state": "Colorado" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04229017" }, { "nct_id": "NCT06063850", "title": "AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Mesial Temporal Lobe Epilepsy" ], "interventions": [ { "name": "AAV9-hSyn1-miGRIK2", "type": "GENETIC" } ], "intervention_types": [ "GENETIC" ], "sponsor": "UniQure Biopharma B.V.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 12, "start_date": "2024-06-12", "completion_date": "2031-12", "has_results": false, "last_update_posted_date": "2026-08-24", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 18, "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Palo Alto, California + 15 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Palo Alto", "state": "California" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Kansas City", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06063850" }, { "nct_id": "NCT00838435", "title": "Effect of Kuvan on Neurocognitive Function, Blood Phenylalanine Level, Safety, and Pharmacokinetics in Children With PKU", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Phenylketonuria" ], "interventions": [ { "name": "sapropterin dihydrochloride", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "BioMarin Pharmaceutical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "6 Years", "sex": "ALL", "summary": "Up to 6 Years" }, "enrollment_count": 95, "start_date": "2009-02", "completion_date": "2018-09-14", "has_results": true, "last_update_posted_date": "2020-12-22", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 12, "location_summary": "La Jolla, California • Orange, California • Tampa, Florida + 9 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Tampa", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00838435" }, { "nct_id": "NCT00077662", "title": "A Prospective, Observational Study in Patients With Late-Onset Pompe Disease", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Glycogen Storage Disease Type II" ], "interventions": [], "intervention_types": [], "sponsor": "Genzyme, a Sanofi Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "8 Years", "maximum_age": null, "sex": "ALL", "summary": "8 Years and older" }, "enrollment_count": 61, "start_date": "2004-03", "completion_date": "2006-01", "has_results": false, "last_update_posted_date": "2015-05-05", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 3, "location_summary": "Washington D.C., District of Columbia • St Louis, Missouri • Seattle, Washington", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "St Louis", "state": "Missouri" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00077662" }, { "nct_id": "NCT05436262", "title": "Using Real-time fMRI Neurofeedback and Motor Imagery to Enhance Motor Timing and Precision in Cerebellar Ataxia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Cerebellar Ataxia", "Spinocerebellar Ataxias", "Cerebellar Degeneration" ], "interventions": [ { "name": "Real-time fMRI with neurofeedback of motor imagery", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Johns Hopkins University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 21, "start_date": "2023-03-14", "completion_date": "2024-01-22", "has_results": true, "last_update_posted_date": "2025-01-08", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT05436262" }, { "nct_id": "NCT00001410", "title": "PEG-Glucocerebrosidase for the Treatment of Gaucher Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Gaucher's Disease" ], "interventions": [ { "name": "Lysodase", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Mental Health (NIMH)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 18, "start_date": "1993-10", "completion_date": "2001-12", "has_results": false, "last_update_posted_date": "2008-03-04", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00001410" }, { "nct_id": "NCT00237627", "title": "Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Breast Cancer", "Leukemia", "Lymphoma", "Multiple Myeloma and Plasma Cell Neoplasm", "Ovarian Cancer", "Unspecified Adult Solid Tumor, Protocol Specific" ], "interventions": [ { "name": "PS-341", "type": "DRUG" }, { "name": "Doxil", "type": "DRUG" }, { "name": "Velcade", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "UNC Lineberger Comprehensive Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 107, "start_date": "2001-05", "completion_date": "2010-01", "has_results": false, "last_update_posted_date": "2012-05-18", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 1, "location_summary": "Chapel Hill, North Carolina", "locations": [ { "city": "Chapel Hill", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00237627" }, { "nct_id": "NCT05596760", "title": "Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dementia", "Dementia, Vascular", "Mixed Dementias", "Alzheimer Disease", "Huntington Disease", "Lewy Body Disease", "Creutzfeldt-Jakob Syndrome", "Frontotemporal Lobar Degeneration", "Cognitive Dysfunction", "Cognitive Aging", "Chronic Disease", "Palliative Care, Patient Care", "Health Care Quality, Access, and Evaluation", "Patient Care", "Health Communication", "Patient Care Planning", "Quality of Life" ], "interventions": [ { "name": "Jumpstart Guide", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of Washington", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1802, "start_date": "2023-09-11", "completion_date": "2027-07-01", "has_results": false, "last_update_posted_date": "2026-09-21", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 3, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" }, { "city": "Seattle", "state": "Washington" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT05596760" }, { "nct_id": "NCT03059420", "title": "Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Congenital Fibrosis of Extraocular Muscles", "Duane Retraction Syndrome", "Duane Radial Ray Syndrome", "Mobius Syndrome", "Brown Syndrome", "Marcus Gunn Syndrome", "Strabismus Congenital", "Horizontal Gaze Palsy", "Horizontal Gaze Palsy With Progressive Scoliosis", "Facial Palsy", "Facial Paresis, Hereditary, Congenital", "Third Nerve Palsy", "Fourth Nerve Palsy", "Sixth Nerve Palsy", "Synkinesis", "Ocular Motility Disorders", "Levator-Medial Rectus Synkinesis", "Athabaskan Brainstem Dysgenesis", "Tongue Paralysis", "Ninth Nerve Disorder", "Fifth Nerve Palsy", "Seventh Nerve Palsy", "Eleventh Nerve Disorder", "Twelfth Nerve Disorder", "Vagus Nerve Paralysis", "Moebius Sequence" ], "interventions": [], "intervention_types": [], "sponsor": "Boston Children's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "1 Day", "maximum_age": null, "sex": "ALL", "summary": "1 Day and older" }, "enrollment_count": 20000, "start_date": "2004-02-01", "completion_date": "2030-01", "has_results": false, "last_update_posted_date": "2026-02-11", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT03059420" }, { "nct_id": "NCT03355209", "title": "A Study to Investigate the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) as an Adjunctive Therapy in Children and Adults With Lennox-Gastaut Syndrome", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Lennox Gastaut Syndrome" ], "interventions": [ { "name": "ZX008 0.2 or 0.8 mg/kg/day", "type": "DRUG" }, { "name": "Matching Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "35 Years", "sex": "ALL", "summary": "2 Years to 35 Years" }, "enrollment_count": 296, "start_date": "2017-11-27", "completion_date": "2024-05-23", "has_results": true, "last_update_posted_date": "2025-07-03", "last_synced_at": "2026-10-24T15:58:24.540Z", "location_count": 30, "location_summary": "Tucson, Arizona • Los Angeles, California • San Francisco, California + 26 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT03355209" } ] }