{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Degenerative+Disorder&page=2",
    "query": {
      "condition": "Central Nervous System Degenerative Disorder",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Degenerative+Disorder&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T14:55:53.589Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04165213",
      "title": "Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Frontotemporal Dementia",
        "Dementia",
        "Multi-Infarct Dementia",
        "Vascular Dementia",
        "Mixed Dementia",
        "Alzheimer Disease",
        "Lewy Body Disease",
        "Pick Disease",
        "Neurocognitive Disorders"
      ],
      "interventions": [
        {
          "name": "Care of Older Persons in their Environment (COPE) online module training",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "21 Years to 100 Years"
      },
      "enrollment_count": 85,
      "start_date": "2021-06-28",
      "completion_date": "2024-05-31",
      "has_results": true,
      "last_update_posted_date": "2025-06-26",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04165213"
    },
    {
      "nct_id": "NCT04049266",
      "title": "A Study to Evaluate the Efficacy and Safety of KSI-301, an Anti-VEGF Antibody Biopolymer Conjugate, Versus Aflibercept in Patients With Neovascular (Wet) Age-Related Macular Degeneration.",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Wet Macular Degeneration"
      ],
      "interventions": [
        {
          "name": "KSI-301",
          "type": "DRUG"
        },
        {
          "name": "Aflibercept",
          "type": "DRUG"
        },
        {
          "name": "Sham Procedure",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Kodiak Sciences Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 559,
      "start_date": "2019-10-08",
      "completion_date": "2022-04-26",
      "has_results": true,
      "last_update_posted_date": "2024-07-18",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 59,
      "location_summary": "Phoenix, Arizona • Springdale, Arkansas • Bakersfield, California + 53 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Springdale",
          "state": "Arkansas"
        },
        {
          "city": "Bakersfield",
          "state": "California"
        },
        {
          "city": "Beverly Hills",
          "state": "California"
        },
        {
          "city": "Fresno",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04049266"
    },
    {
      "nct_id": "NCT05012410",
      "title": "WeCareAdvisor Study for Caregivers of People Living With Dementia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dementia",
        "Caregiver Burnout",
        "Caregiver Stress Syndrome",
        "Alzheimer Disease",
        "Frontotemporal Dementia",
        "Vascular Dementia",
        "Dementia With Lewy Bodies"
      ],
      "interventions": [
        {
          "name": "Immediate treatment group with High-Intensity Prompts",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Immediate treatment group with Low-Intensity Prompts",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Waitlist Control after three months with High-Intensity Prompts",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Waitlist Control after three months with Low-Intensity Prompts",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Drexel University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 262,
      "start_date": "2021-12-13",
      "completion_date": "2024-07-19",
      "has_results": false,
      "last_update_posted_date": "2025-09-30",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05012410"
    },
    {
      "nct_id": "NCT02273596",
      "title": "Efficacy and Safety Study of WTX101 (ALXN1840) in Adult Wilson Disease Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Wilson Disease"
      ],
      "interventions": [
        {
          "name": "ALXN1840",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Alexion Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 29,
      "start_date": "2014-11-24",
      "completion_date": "2018-11-07",
      "has_results": true,
      "last_update_posted_date": "2021-09-29",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 4,
      "location_summary": "Los Angeles, California • New Haven, Connecticut • Chicago, Illinois + 1 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02273596"
    },
    {
      "nct_id": "NCT05338710",
      "title": "Support Via Technology: Living and Learning With Advancing FTD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Caregivers Burnout",
        "Frontotemporal Dementia"
      ],
      "interventions": [
        {
          "name": "STELLA-FTD",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 16,
      "start_date": "2021-01-14",
      "completion_date": "2022-03-04",
      "has_results": true,
      "last_update_posted_date": "2025-11-25",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05338710"
    },
    {
      "nct_id": "NCT06623890",
      "title": "A Study to Learn More About the Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Who Are Prescribed it by Their Own Doctors",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Friedreich Ataxia"
      ],
      "interventions": [
        {
          "name": "Omaveloxolone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Biogen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2024-12-12",
      "completion_date": "2029-10-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-28",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 4,
      "location_summary": "Los Angeles, California • Aurora, Colorado • Gainesville, Florida + 1 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Gainesville",
          "state": "Florida"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06623890"
    },
    {
      "nct_id": "NCT05344989",
      "title": "A First-in-Human Study to Assess Single Doses of APNmAb005 in Healthy Participants",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Healthy Volunteers",
        "Tauopathies",
        "Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "APNmAb005",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "APRINOIA Therapeutics, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 40,
      "start_date": "2022-05-06",
      "completion_date": "2024-07",
      "has_results": false,
      "last_update_posted_date": "2023-06-15",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 1,
      "location_summary": "Long Beach, California",
      "locations": [
        {
          "city": "Long Beach",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05344989"
    },
    {
      "nct_id": "NCT07348250",
      "title": "Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Parkinson's Disease (PD)",
        "Parkinson's Disease",
        "Parkinson's Disease (Disorder)"
      ],
      "interventions": [
        {
          "name": "[18F]MK-0947",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Invicro",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 22,
      "start_date": "2025-12-08",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-06-26",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 2,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07348250"
    },
    {
      "nct_id": "NCT00024908",
      "title": "Test of A Model of Representational Knowledge Stored in the Human Prefrontal Cortex",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Intracranial Central Nervous System Disorder",
        "Mental Disorder",
        "Healthy"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "6 Years to 90 Years"
      },
      "enrollment_count": 949,
      "start_date": "2001-10-01",
      "completion_date": "2010-04-07",
      "has_results": false,
      "last_update_posted_date": "2017-07-02",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00024908"
    },
    {
      "nct_id": "NCT04881617",
      "title": "Treatment for Speech and Language in Primary Progressive Aphasia",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Primary Progressive Aphasia",
        "Semantic Dementia",
        "Semantic Memory Disorder",
        "Logopenic Progressive Aphasia",
        "Nonfluent Aphasia, Progressive",
        "Aphasia",
        "Aphasia, Progressive"
      ],
      "interventions": [
        {
          "name": "Lexical Retrieval Training (LRT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Video-Implemented Script Training for Aphasia (VISTA)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Texas at Austin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 60,
      "start_date": "2017-07-01",
      "completion_date": "2025-12-30",
      "has_results": false,
      "last_update_posted_date": "2025-11-13",
      "last_synced_at": "2026-07-23T14:55:53.589Z",
      "location_count": 2,
      "location_summary": "San Francisco, California • Austin, Texas",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04881617"
    }
  ]
}