{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Depression", "query": { "condition": "Central Nervous System Depression" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 359, "total_pages": 36, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Depression&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-06-11T06:01:58.718Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03964350", "title": "Behavior Brain Responses", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Alcohol Drinking", "Drinking Behavior", "Physiological Effects of Drugs", "Central Nervous System Depression" ], "interventions": [ { "name": "Ethanol", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "University of Chicago", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "35 Years", "sex": "MALE", "summary": "21 Years to 35 Years · Male only" }, "enrollment_count": 30, "start_date": "2019-05-28", "completion_date": "2020-12-31", "has_results": true, "last_update_posted_date": "2025-01-31", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03964350" }, { "nct_id": "NCT00965497", "title": "Escitalopram (Lexapro) for Depression MS or ALS", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Major Depression", "Multiple Sclerosis", "Amyotrophic Lateral Sclerosis" ], "interventions": [ { "name": "escitalopram", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of South Carolina", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 13, "start_date": "2009-07", "completion_date": "2010-03", "has_results": true, "last_update_posted_date": "2019-05-01", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Columbia, South Carolina", "locations": [ { "city": "Columbia", "state": "South Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00965497" }, { "nct_id": "NCT02909387", "title": "Adapting Project UPLIFT for Blacks in Georgia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Epilepsy", "Depressive Symptoms", "Anxiety Disorders and Symptoms" ], "interventions": [ { "name": "Project UPLIFT", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Morehouse School of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 82, "start_date": "2016-09-08", "completion_date": "2019-09-30", "has_results": false, "last_update_posted_date": "2020-06-23", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Atlanta, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02909387" }, { "nct_id": "NCT06644573", "title": "Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Chronic Insomnia", "Sleep Deprivation", "REM Behavior Disorder", "REM Sleep Behavior Disorder", "REM Sleep Measurement", "Insomnia", "Insomnia Related to Specified Disorder", "Insomnia Due to Other Mental Disorder", "Insomnia Comorbid to Psychiatric Disorder", "Insomnia Due to Anxiety and Fear", "Insomnia Related to Another Mental Condition", "Insomnia Disorders", "Idiopathic Hypersomnia", "Sleep Disorders, Circadian Rhythm", "Post Trauma Nightmares", "PTSD - Post Traumatic Stress Disorder", "Sleep Quality", "Anesthesia", "Anxiety", "Depression", "Mental Health", "Alzheimer Disease or Associated Disorder", "Parkinsons", "Circadian Rhythm", "Circadian Dysregulation", "PTSD", "Post-Traumatic", "Post-Traumatic Stress Disorder Complex", "Military Combat Stress Reaction", "Sleep", "Military Activity", "Veterans", "Shift Work Sleep Disorder", "Menopause Related Conditions", "Pain", "Cancer Pain", "Athletes" ], "interventions": [ { "name": "PROSOMNIA Sleep Therapy™ (PSTx)", "type": "PROCEDURE" }, { "name": "Anesthesia-Induced Sleep Therapy", "type": "PROCEDURE" }, { "name": "Diprivan (propofol), Astra-Zeneca", "type": "DRUG" }, { "name": "Continuous EEG Monitoring", "type": "DEVICE" } ], "intervention_types": [ "PROCEDURE", "DRUG", "DEVICE" ], "sponsor": "Nyree Penn", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 100, "start_date": "2025-11-01", "completion_date": "2026-05-01", "has_results": false, "last_update_posted_date": "2025-05-28", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Aventura, Florida", "locations": [ { "city": "Aventura", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06644573" }, { "nct_id": "NCT04806620", "title": "Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Post-Acute COVID-19 Syndrome", "ME/CFS", "Rheumatic Arthritis", "Juvenile Rheumatoid Arthritis (JRA)", "Psoriatic Arthritis (PsA)", "Ankylosing Spondylitis (AS)", "Autoimmune Encephalitis", "Celiac Disease", "Celiac Disease in Children", "Chronic Lyme Disease", "Post-treatment Lyme Disease Syndrome", "Crohn's Disease", "Dysautonomia", "Anorexia Nervosa", "Bulimia Nervosa", "ARFID", "Avoidant / Restrictive Food Intake Disorder", "Ehlers Danlos Syndrome", "Endometriosis", "Fibromyalgia (FM)", "Long COVID", "Lupus", "Migraines", "Mast Cell Activation Syndrome", "Multiple Sclerosis", "Myalgic Encephalomyelitis (ME)", "Myasthenia Gravis, Generalized", "Myasthenia Gravis in Children", "Narcolepsy", "Obsessive Compulsive Disorder (OCD)", "PANDAS", "Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)", "POTS - Postural Orthostatic Tachycardia Syndrome", "General Anxiety Disorder, Social Anxiety Disorder", "PTSD - Post Traumatic Stress Disorder", "Psoriasis", "Traumatic Brain Injury", "Tourette's Syndrome", "Inflammatory Bowel Disease (IBD)", "Autoimmune Diseases", "Neurological Diseases or Conditions", "Psychiatric Disorder", "Sjogren's Syndrome", "Ulcerative Colitis and Crohn's Disease" ], "interventions": [], "intervention_types": [], "sponsor": "Brain Inflammation Collaborative", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "2 Years", "maximum_age": null, "sex": "ALL", "summary": "2 Years and older" }, "enrollment_count": 10000, "start_date": "2023-07-05", "completion_date": "2030-12-31", "has_results": false, "last_update_posted_date": "2026-01-22", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Delafield, Wisconsin", "locations": [ { "city": "Delafield", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT04806620" }, { "nct_id": "NCT04845542", "title": "Promoting Resilience in Stroke Survivor-carepartner Dyads (ReStoreD)", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Stroke", "Depression, Anxiety", "Coping Skills", "Couples" ], "interventions": [ { "name": "ReStoreD", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of Utah", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 400, "start_date": "2022-07-20", "completion_date": "2027-08-31", "has_results": false, "last_update_posted_date": "2026-01-30", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT04845542" }, { "nct_id": "NCT03464383", "title": "Anxiety and Depression in Epilepsy: A Treatment Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Anxiety", "Depression", "Epilepsy" ], "interventions": [ { "name": "Escitalopram 10mg", "type": "DRUG" }, { "name": "Referral to Psychiatry", "type": "OTHER" }, { "name": "Survey only", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Wake Forest University Health Sciences", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 69, "start_date": "2018-05-07", "completion_date": "2019-09-20", "has_results": true, "last_update_posted_date": "2020-10-19", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Winston-Salem, North Carolina", "locations": [ { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT03464383" }, { "nct_id": "NCT00781326", "title": "Effectiveness of Nimodipine Plus Antidepressant Medication in Treating Vascular Depression", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Depression" ], "interventions": [ { "name": "Nimodipine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pittsburgh", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 9, "start_date": "2008-08", "completion_date": "2009-02", "has_results": true, "last_update_posted_date": "2016-09-29", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00781326" }, { "nct_id": "NCT01765218", "title": "Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Hypoxic Ischemic Encephalopathy" ], "interventions": [ { "name": "Topiramate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Kristin R Hoffman", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "6 Hours", "sex": "ALL", "summary": "Up to 6 Hours" }, "enrollment_count": 34, "start_date": "2013-02", "completion_date": "2022-01-27", "has_results": true, "last_update_posted_date": "2024-06-11", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Sacramento, California", "locations": [ { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01765218" }, { "nct_id": "NCT01167608", "title": "Barriers to Mental Healthcare Utilization in Parkinson's Disease", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Parkinson's Disease", "Depression", "Anxiety" ], "interventions": [ { "name": "No Intervention. This is a cross-sectional survey study.", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Rutgers, The State University of New Jersey", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 883, "start_date": "2010-06", "completion_date": "2013-03", "has_results": true, "last_update_posted_date": "2019-07-16", "last_synced_at": "2026-06-11T06:01:58.718Z", "location_count": 1, "location_summary": "Piscataway, New Jersey", "locations": [ { "city": "Piscataway", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT01167608" } ] }