{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Disease&page=46", "query": { "condition": "Central Nervous System Disease", "page": 46 }, "page_size": 10 }, "pagination": { "page": 46, "page_size": 10, "total_count": 16380, "total_pages": 1638, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Disease&page=47&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Central+Nervous+System+Disease&page=45&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-17T16:37:57.961Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07598708", "title": "A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Narcolepsy Type 1", "Narcolepsy Type 2" ], "interventions": [ { "name": "cleminorexton", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Centessa Pharmaceuticals (UK) Limited", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 222, "start_date": "2026-05-29", "completion_date": "2027-12-31", "has_results": false, "last_update_posted_date": "2026-10-02", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 23, "location_summary": "Birmingham, Alabama • Colorado Springs, Colorado • Brandon, Florida + 17 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Colorado Springs", "state": "Colorado" }, { "city": "Brandon", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07598708" }, { "nct_id": "NCT04257435", "title": "The Utility of Positive Psychology in Military TBI Rehabilitation", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Traumatic Brain Injury" ], "interventions": [ { "name": "Positive Psychological Group Treatment", "type": "BEHAVIORAL" }, { "name": "Traditional Behavioral Health Treatment", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "Fort Belvoir Community Hospital", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2019-09", "completion_date": "2021-10", "has_results": false, "last_update_posted_date": "2020-02-06", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 1, "location_summary": "Fort Belvoir, Virginia", "locations": [ { "city": "Fort Belvoir", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT04257435" }, { "nct_id": "NCT07129317", "title": "Pediatric Radiation Therapy Registry", "overall_status": "RECRUITING", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Sarcoma", "Pediatric Brain Tumors" ], "interventions": [], "intervention_types": [], "sponsor": "Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "0 Years", "maximum_age": "26 Years", "sex": "ALL", "summary": "0 Years to 26 Years" }, "enrollment_count": 5000, "start_date": "2025-10-31", "completion_date": "2040-09", "has_results": false, "last_update_posted_date": "2025-11-05", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 2, "location_summary": "Washington D.C., District of Columbia • Baltimore, Maryland", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT07129317" }, { "nct_id": "NCT03670914", "title": "Diagnosis of Sleep-Related Respiratory Disorders in Patients With Narcotic Medications", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Narcotic Use", "Central Sleep Apnea" ], "interventions": [ { "name": "WatchPAT 200", "type": "DIAGNOSTIC_TEST" } ], "intervention_types": [ "DIAGNOSTIC_TEST" ], "sponsor": "Kaiser Permanente", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 24, "start_date": "2019-08-08", "completion_date": "2025-03-13", "has_results": false, "last_update_posted_date": "2026-07-20", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 1, "location_summary": "Fontana, California", "locations": [ { "city": "Fontana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03670914" }, { "nct_id": "NCT00084838", "title": "Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Central Nervous System Tumor, Pediatric" ], "interventions": [ { "name": "filgrastim", "type": "BIOLOGICAL" }, { "name": "cisplatin", "type": "DRUG" }, { "name": "cyclophosphamide", "type": "DRUG" }, { "name": "cytarabine", "type": "DRUG" }, { "name": "dexrazoxane hydrochloride", "type": "DRUG" }, { "name": "doxorubicin hydrochloride", "type": "DRUG" }, { "name": "etoposide", "type": "DRUG" }, { "name": "leucovorin calcium", "type": "DRUG" }, { "name": "methotrexate", "type": "DRUG" }, { "name": "temozolomide", "type": "DRUG" }, { "name": "therapeutic hydrocortisone", "type": "DRUG" }, { "name": "vincristine sulfate", "type": "DRUG" }, { "name": "radiation therapy", "type": "RADIATION" }, { "name": "Dactinomycin", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG", "RADIATION" ], "sponsor": "Dana-Farber Cancer Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "18 Years", "sex": "ALL", "summary": "Up to 18 Years" }, "enrollment_count": 25, "start_date": "2003-02", "completion_date": "2013-03", "has_results": true, "last_update_posted_date": "2015-12-24", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 12, "location_summary": "Stanford, California • New Haven, Connecticut • Atlanta, Georgia + 8 more", "locations": [ { "city": "Stanford", "state": "California" }, { "city": "New Haven", "state": "Connecticut" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00084838" }, { "nct_id": "NCT04377555", "title": "Prospective Study to Assess Disease Activity and Biomarkers in Minority Participants With Relapsing Multiple Sclerosis (RMS) After Initiation and During Treatment With Ocrelizumab", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Multiple Sclerosis, Relapsing" ], "interventions": [ { "name": "Ocrelizumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Genentech, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 179, "start_date": "2020-07-30", "completion_date": "2025-11-11", "has_results": false, "last_update_posted_date": "2026-02-04", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 26, "location_summary": "Phoenix, Arizona • Los Angeles, California • Washington D.C., District of Columbia + 19 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Jacksonville Beach", "state": "Florida" }, { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04377555" }, { "nct_id": "NCT00313885", "title": "Efficacy and Safety of SR46349B in Patients With Sleep Disorders in Fibromyalgia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Fibromyalgia", "Sleep", "Chronic Pain" ], "interventions": [ { "name": "eplivanserin (SR46349)", "type": "DRUG" }, { "name": "placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Sanofi", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 205, "start_date": "2004-04", "completion_date": "2005-06", "has_results": false, "last_update_posted_date": "2010-11-30", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 11, "location_summary": "Phoenix, Arizona • San Diego, California • Jacksonville, Florida + 8 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Ocala", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT00313885" }, { "nct_id": "NCT00838435", "title": "Effect of Kuvan on Neurocognitive Function, Blood Phenylalanine Level, Safety, and Pharmacokinetics in Children With PKU", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Phenylketonuria" ], "interventions": [ { "name": "sapropterin dihydrochloride", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "BioMarin Pharmaceutical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "6 Years", "sex": "ALL", "summary": "Up to 6 Years" }, "enrollment_count": 95, "start_date": "2009-02", "completion_date": "2018-09-14", "has_results": true, "last_update_posted_date": "2020-12-22", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 12, "location_summary": "La Jolla, California • Orange, California • Tampa, Florida + 9 more", "locations": [ { "city": "La Jolla", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Tampa", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00838435" }, { "nct_id": "NCT01856335", "title": "Exercise Education for Adults With Seizure Disorders", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Seizures", "Epilepsy" ], "interventions": [ { "name": "Patient Education", "type": "OTHER" }, { "name": "exercise: increase physical activity/goal setting", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2013-05-10", "completion_date": "2018-12-07", "has_results": false, "last_update_posted_date": "2018-12-11", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01856335" }, { "nct_id": "NCT01363258", "title": "Reducing Care-Resistant Behaviors During Oral Hygiene in Persons With Dementia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Care-resistant Behavior", "Dementia" ], "interventions": [ { "name": "Care-resistant mouth care (MOUTh)", "type": "BEHAVIORAL" }, { "name": "Evidence-based mouth care", "type": "PROCEDURE" } ], "intervention_types": [ "BEHAVIORAL", "PROCEDURE" ], "sponsor": "University of Alabama at Birmingham", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": null, "sex": "ALL", "summary": "55 Years and older" }, "enrollment_count": 100, "start_date": "2011-04", "completion_date": "2015-11", "has_results": true, "last_update_posted_date": "2018-06-07", "last_synced_at": "2026-10-17T16:37:57.961Z", "location_count": 4, "location_summary": "Bellefonte, Pennsylvania • Harrisburg, Pennsylvania • York, Pennsylvania", "locations": [ { "city": "Bellefonte", "state": "Pennsylvania" }, { "city": "Harrisburg", "state": "Pennsylvania" }, { "city": "York", "state": "Pennsylvania" }, { "city": "York", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01363258" } ] }