{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cerebral+Cortex+Dysfunction",
    "query": {
      "condition": "Cerebral Cortex Dysfunction"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 22,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cerebral+Cortex+Dysfunction&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T11:04:17.509Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02414282",
      "title": "F 18 T807 Tau PET Imaging of Progressive Posterior Cortical Dysfunction (IND 123119, Protocol E)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease",
        "Progressive Posterior Cortical Dysfunction (PPCD)"
      ],
      "interventions": [
        {
          "name": "F 18 T807",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tammie L. S. Benzinger, MD, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "45 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2015-03",
      "completion_date": "2020-10-20",
      "has_results": false,
      "last_update_posted_date": "2021-01-19",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02414282"
    },
    {
      "nct_id": "NCT05762796",
      "title": "Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Brain Concussion",
        "Mild Traumatic Brain Injury",
        "Motor Disorders",
        "Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "tDCS in Youth with mild traumatic brain injury",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "State University of New York at Buffalo",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "15 Years",
        "sex": "ALL",
        "summary": "10 Years to 15 Years"
      },
      "enrollment_count": 10,
      "start_date": "2024-02-20",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2026-02-03",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "Buffalo, New York",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05762796"
    },
    {
      "nct_id": "NCT04120766",
      "title": "Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dementia",
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Nicorandil",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Gregory Jicha, MD, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "70 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "70 Years and older"
      },
      "enrollment_count": 64,
      "start_date": "2021-12-01",
      "completion_date": "2026-11-30",
      "has_results": false,
      "last_update_posted_date": "2025-12-15",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04120766"
    },
    {
      "nct_id": "NCT00001258",
      "title": "Studies of Frontal Lobe Brain Functioning in Schizophrenia",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Healthy Subjects",
        "Schizophrenia",
        "Parkinson Disease"
      ],
      "interventions": [
        {
          "name": "Oxygen-15 Water",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute of Mental Health (NIMH)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 1039,
      "start_date": "1993-11-26",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2026-07-14",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00001258"
    },
    {
      "nct_id": "NCT06218407",
      "title": "Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Chronic Pain",
        "Low Back Pain"
      ],
      "interventions": [
        {
          "name": "Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) short burst paradigm",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) long burst paradigm",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Computerized Chemosensory-Based Orbitofrontal Cortex Training plus beta caryophyllene (CBOT-Plus)",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT)",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Evon Medics LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 86,
      "start_date": "2023-04-27",
      "completion_date": "2023-09-15",
      "has_results": false,
      "last_update_posted_date": "2024-01-23",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06218407"
    },
    {
      "nct_id": "NCT07222605",
      "title": "Research Study for Patients With Neurological Diseases Which Evaluates the Patient Experience of the MemorEM Device",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alzheimer Disease",
        "Parkinson Disease",
        "Frontotemporal Dementia",
        "Cortico Basal Degeneration",
        "Posterior Cortical Atrophy (PCA)",
        "Neurological Diseases or Conditions",
        "Dementia"
      ],
      "interventions": [
        {
          "name": "MemorEM",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "eQ8Health Corporation d/b/a CareONE Concierge",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "45 Years to 100 Years"
      },
      "enrollment_count": 1000,
      "start_date": "2025-12-01",
      "completion_date": "2029-12-15",
      "has_results": false,
      "last_update_posted_date": "2026-02-05",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07222605"
    },
    {
      "nct_id": "NCT04105530",
      "title": "Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Lymphoblastic Leukemia",
        "Transcranial Direct Current Stimulation",
        "Executive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Anodal tDCS treatment",
          "type": "DEVICE"
        },
        {
          "name": "Cathodal tDCS treatment",
          "type": "DEVICE"
        },
        {
          "name": "Sham treatment",
          "type": "DEVICE"
        },
        {
          "name": "NIH Toolbox List Sorting Working Memory Test",
          "type": "OTHER"
        },
        {
          "name": "NIH Toolbox Flanker Inhibitory Control and Attention Test",
          "type": "OTHER"
        },
        {
          "name": "Grooved Peg Board Test",
          "type": "OTHER"
        },
        {
          "name": "Buschke Selective Reminding Test",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "St. Jude Children's Research Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": "215 Months",
        "sex": "ALL",
        "summary": "8 Years to 215 Months"
      },
      "enrollment_count": 36,
      "start_date": "2019-11-18",
      "completion_date": "2024-09",
      "has_results": false,
      "last_update_posted_date": "2024-01-12",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "Memphis, Tennessee",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04105530"
    },
    {
      "nct_id": "NCT06671132",
      "title": "Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Chronic Pain",
        "Low Back Pain"
      ],
      "interventions": [
        {
          "name": "Computerized Chemosensory-Based Orbitofrontal Cortex Training for Pain",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT)",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Evon Medics LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 220,
      "start_date": "2024-10-23",
      "completion_date": "2026-01-30",
      "has_results": false,
      "last_update_posted_date": "2024-11-04",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 2,
      "location_summary": "Washington D.C., District of Columbia • Pasadena, Maryland",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Pasadena",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06671132"
    },
    {
      "nct_id": "NCT00334516",
      "title": "Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cerebral Cortex Dysfunction"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 77,
      "start_date": "2006-06-06",
      "completion_date": "2015-08-03",
      "has_results": false,
      "last_update_posted_date": "2019-05-31",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00334516"
    },
    {
      "nct_id": "NCT00935493",
      "title": "Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognitive Aging"
      ],
      "interventions": [
        {
          "name": "Guanfacine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "75 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "75 Years and older"
      },
      "enrollment_count": 154,
      "start_date": "2009-06",
      "completion_date": "2012-08",
      "has_results": true,
      "last_update_posted_date": "2014-08-13",
      "last_synced_at": "2026-07-23T11:04:17.509Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00935493"
    }
  ]
}