{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cerebrospinal+Fluid+Leakage",
    "query": {
      "condition": "Cerebrospinal Fluid Leakage"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 18,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cerebrospinal+Fluid+Leakage&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-26T00:17:24.697Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03181464",
      "title": "Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Postdural Puncture Headache",
        "Cerebrospinal Fluid Leak",
        "Spinal; Puncture, Complications, Headache"
      ],
      "interventions": [
        {
          "name": "Lidocaine 4%",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 0,
      "start_date": "2018-04-17",
      "completion_date": "2019-01-30",
      "has_results": false,
      "last_update_posted_date": "2019-02-12",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03181464"
    },
    {
      "nct_id": "NCT00444067",
      "title": "Study to Evaluate Safety & Effectiveness of Spinal Sealant",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cerebrospinal Fluid Leakage, Subdural"
      ],
      "interventions": [
        {
          "name": "Spinal Sealant",
          "type": "DEVICE"
        },
        {
          "name": "Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Integra LifeSciences Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 98,
      "start_date": "2007-05",
      "completion_date": "2009-08",
      "has_results": true,
      "last_update_posted_date": "2017-09-07",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 1,
      "location_summary": "Bedford, Massachusetts",
      "locations": [
        {
          "city": "Bedford",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00444067"
    },
    {
      "nct_id": "NCT04923867",
      "title": "Suturable DuraGen™ PMCF Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cerebrospinal Fluid Leak"
      ],
      "interventions": [
        {
          "name": "Suturable DuraGen™",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Integra LifeSciences Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 106,
      "start_date": "2021-04-28",
      "completion_date": "2024-07-31",
      "has_results": false,
      "last_update_posted_date": "2025-04-06",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 3,
      "location_summary": "Aurora, Colorado • Jacksonville, Florida • Portland, Oregon",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04923867"
    },
    {
      "nct_id": "NCT02495545",
      "title": "Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injury"
      ],
      "interventions": [
        {
          "name": "CSFD and elevation of MAP",
          "type": "PROCEDURE"
        },
        {
          "name": "Maintenance of MAP",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "St. Joseph's Hospital and Medical Center, Phoenix",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 15,
      "start_date": "2015-10",
      "completion_date": "2019-10-25",
      "has_results": false,
      "last_update_posted_date": "2019-11-27",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 3,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02495545"
    },
    {
      "nct_id": "NCT02891070",
      "title": "Efficacy and Safety of FS VH S/D 500 S-apr (Tisseel) as an Adjunct to Sutured Dural Repair in Cranial Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Cerebrospinal Fluid Leak"
      ],
      "interventions": [
        {
          "name": "FS VH S/D 500 s-apr",
          "type": "DRUG"
        },
        {
          "name": "DuraSeal Dural Sealant",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Baxter Healthcare Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 224,
      "start_date": "2016-10-11",
      "completion_date": "2018-08-22",
      "has_results": true,
      "last_update_posted_date": "2019-09-10",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 10,
      "location_summary": "Springfield, Illinois • Springfield, Massachusetts • Detroit, Michigan + 7 more",
      "locations": [
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Springfield",
          "state": "Massachusetts"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02891070"
    },
    {
      "nct_id": "NCT02603549",
      "title": "Pituitary Function and Spontaneous Intracranial Hypotension",
      "overall_status": "SUSPENDED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hyperprolactinemia",
        "Spontaneous Intracranial Hypotension"
      ],
      "interventions": [
        {
          "name": "Pituitary panel will be drawn pre-op and post-op for all patients.",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2015-07",
      "completion_date": "2020-12",
      "has_results": false,
      "last_update_posted_date": "2019-01-31",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02603549"
    },
    {
      "nct_id": "NCT01977898",
      "title": "Incidence of Headache Following an Unintentional Dural Puncture",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Postdural Puncture Headache",
        "Post-Lumbar Puncture Headache",
        "Cerebrospinal Fluid Leaks"
      ],
      "interventions": [
        {
          "name": "Morphine",
          "type": "DRUG"
        },
        {
          "name": "Saline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Northwestern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 68,
      "start_date": "2011-11",
      "completion_date": "2019-03-01",
      "has_results": true,
      "last_update_posted_date": "2021-11-17",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01977898"
    },
    {
      "nct_id": "NCT04498026",
      "title": "Adherus™ Dural Sealant in Spinal Procedures",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Duraplasty"
      ],
      "interventions": [
        {
          "name": "Adherus Dural Sealant System",
          "type": "DEVICE"
        },
        {
          "name": "DuraSeal Exact Dural Sealant System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Stryker Craniomaxillofacial",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 114,
      "start_date": "2020-11-19",
      "completion_date": "2025-12",
      "has_results": false,
      "last_update_posted_date": "2025-02-24",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 14,
      "location_summary": "Duarte, California • Sacramento, California • Stanford, California + 9 more",
      "locations": [
        {
          "city": "Duarte",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Jacksonville",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04498026"
    },
    {
      "nct_id": "NCT01410864",
      "title": "DuraSeal Exact Spine Sealant System Post-Approval Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Dural Sealing"
      ],
      "interventions": [
        {
          "name": "DuraSeal Exact Spine Sealant System",
          "type": "DEVICE"
        },
        {
          "name": "Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Integra LifeSciences Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 924,
      "start_date": "2011-08",
      "completion_date": "2016-07",
      "has_results": false,
      "last_update_posted_date": "2017-03-01",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 36,
      "location_summary": "Phoenix, Arizona • Los Angeles, California • Sacramento, California + 31 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Jose",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01410864"
    },
    {
      "nct_id": "NCT03276975",
      "title": "A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Cerebrospinal Fluid Leaks"
      ],
      "interventions": [
        {
          "name": "TISSEEL",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2017-12-18",
      "completion_date": "2020-03-19",
      "has_results": true,
      "last_update_posted_date": "2021-06-18",
      "last_synced_at": "2026-06-26T00:17:24.697Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03276975"
    }
  ]
}