{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chromosome+Abnormality&page=5",
    "query": {
      "condition": "Chromosome Abnormality",
      "page": 5
    },
    "page_size": 10
  },
  "pagination": {
    "page": 5,
    "page_size": 10,
    "total_count": 530,
    "total_pages": 53,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chromosome+Abnormality&page=6&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chromosome+Abnormality&page=4&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-07T04:00:29.626Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00056329",
      "title": "Vitamin E in Aging Persons With Down Syndrome",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Down Syndrome",
        "Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "Vitamin E",
          "type": "DRUG"
        },
        {
          "name": "multivitamin",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "New York State Institute for Basic Research",
      "sponsor_class": "OTHER_GOV",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 350,
      "start_date": "2002-04",
      "completion_date": "2012-05",
      "has_results": false,
      "last_update_posted_date": "2012-05-04",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 14,
      "location_summary": "Farmington, Connecticut • Tampa, Florida • Atlanta, Georgia + 10 more",
      "locations": [
        {
          "city": "Farmington",
          "state": "Connecticut"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00056329"
    },
    {
      "nct_id": "NCT02723305",
      "title": "Cardiometabolic Profiles of Boys With Klinefelter Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Klinefelter Syndrome",
        "47,XXY",
        "Sex Chromosome Aneuploidy",
        "XXY Syndrome"
      ],
      "interventions": [
        {
          "name": "No intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "17 Years",
        "sex": "MALE",
        "summary": "12 Years to 17 Years · Male only"
      },
      "enrollment_count": 31,
      "start_date": "2016-05",
      "completion_date": "2017-12",
      "has_results": false,
      "last_update_posted_date": "2022-03-08",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02723305"
    },
    {
      "nct_id": "NCT04020302",
      "title": "Self-Monitoring Shopping Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Intellectual Disability",
        "Down Syndrome"
      ],
      "interventions": [
        {
          "name": "Self-monitoring shopping intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Columbia University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 10,
      "start_date": "2019-09-06",
      "completion_date": "2019-12-20",
      "has_results": false,
      "last_update_posted_date": "2020-01-23",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 1,
      "location_summary": "Hillsborough, New Jersey",
      "locations": [
        {
          "city": "Hillsborough",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04020302"
    },
    {
      "nct_id": "NCT00227253",
      "title": "Chromosome 18 Clinical Research Center",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chromosome Aberrations",
        "Growth Hormone Deficiency",
        "Hypomyelination"
      ],
      "interventions": [
        {
          "name": "Determination of growth hormone status",
          "type": "PROCEDURE"
        },
        {
          "name": "Measurement of growth, thyroid and sex hormone levels",
          "type": "PROCEDURE"
        },
        {
          "name": "Behavior and neuropsychometric evaluations",
          "type": "PROCEDURE"
        },
        {
          "name": "Audiological and ear, nose and throat examination",
          "type": "PROCEDURE"
        },
        {
          "name": "Magnetic resonance imaging of the brain",
          "type": "PROCEDURE"
        },
        {
          "name": "Dysmorphology evaluation",
          "type": "PROCEDURE"
        },
        {
          "name": "Neurology examination",
          "type": "PROCEDURE"
        },
        {
          "name": "Dental evaluation",
          "type": "PROCEDURE"
        },
        {
          "name": "Speech pathology evaluation",
          "type": "PROCEDURE"
        },
        {
          "name": "Psychiatric evaluation",
          "type": "PROCEDURE"
        },
        {
          "name": "Orthopedic evaluation",
          "type": "PROCEDURE"
        },
        {
          "name": "Ophthalmologic evaluation",
          "type": "PROCEDURE"
        },
        {
          "name": "Gastrointestinal evaluation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 4000,
      "start_date": "1993-09",
      "completion_date": "2040-12",
      "has_results": false,
      "last_update_posted_date": "2026-01-06",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 2,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00227253"
    },
    {
      "nct_id": "NCT02126995",
      "title": "A 6-week, Study of MG01CI Low Dose and High Dose Compared With Placebo in Adults and Adolescents With Fragile X Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Fragile X Syndrome"
      ],
      "interventions": [
        {
          "name": "MG01CI extended-release tablet",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Alcobra Ltd.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "15 Years to 55 Years"
      },
      "enrollment_count": 62,
      "start_date": "2014-06",
      "completion_date": "2015-06",
      "has_results": false,
      "last_update_posted_date": "2016-07-06",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 11,
      "location_summary": "Phoenix, Arizona • Sacramento, California • Aurora, Colorado + 8 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02126995"
    },
    {
      "nct_id": "NCT00896272",
      "title": "Adaptation Among Adolescents and Adults With Klinefelter Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Klinefelter Syndrome"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Human Genome Research Institute (NHGRI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "80 Years",
        "sex": "MALE",
        "summary": "14 Years to 80 Years · Male only"
      },
      "enrollment_count": 302,
      "start_date": "2009-05-05",
      "completion_date": "2015-01-13",
      "has_results": false,
      "last_update_posted_date": "2019-12-17",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00896272"
    },
    {
      "nct_id": "NCT02304302",
      "title": "Down Syndrome Memantine Follow-up Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Down Syndrome",
        "Intellectual Disability"
      ],
      "interventions": [
        {
          "name": "Memantine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University Hospitals Cleveland Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "15 Years",
        "maximum_age": "32 Years",
        "sex": "ALL",
        "summary": "15 Years to 32 Years"
      },
      "enrollment_count": 160,
      "start_date": "2014-10",
      "completion_date": "2020-07-22",
      "has_results": true,
      "last_update_posted_date": "2023-06-27",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02304302"
    },
    {
      "nct_id": "NCT00004275",
      "title": "Oxandrolone Compared With a Placebo on Growth Rate in Girls With Growth Hormone-Treated Turner's Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Turner's Syndrome"
      ],
      "interventions": [
        {
          "name": "growth hormone",
          "type": "DRUG"
        },
        {
          "name": "oxandrolone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "14 Years",
        "sex": "FEMALE",
        "summary": "10 Years to 14 Years · Female only"
      },
      "enrollment_count": 80,
      "start_date": "1999-10",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2008-09-10",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00004275"
    },
    {
      "nct_id": "NCT03771469",
      "title": "Validation of Sleep Questionnaires in the Down Syndrome Population",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obstructive Sleep Apnea",
        "Down Syndrome"
      ],
      "interventions": [
        {
          "name": "Sleep study",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Oregon Health and Science University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "2 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "2 Years to 17 Years"
      },
      "enrollment_count": 81,
      "start_date": "2018-06-25",
      "completion_date": "2027-01-01",
      "has_results": false,
      "last_update_posted_date": "2025-09-24",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03771469"
    },
    {
      "nct_id": "NCT03185702",
      "title": "UTHealth Turner Syndrome Research Registry",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Turner Syndrome"
      ],
      "interventions": [
        {
          "name": "Research genetic tests",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "GENETIC"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "Female only"
      },
      "enrollment_count": 200,
      "start_date": "2015-08-28",
      "completion_date": "2035-01-01",
      "has_results": false,
      "last_update_posted_date": "2023-11-28",
      "last_synced_at": "2026-10-07T04:00:29.626Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03185702"
    }
  ]
}