{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Ankle+Sprains",
    "query": {
      "condition": "Chronic Ankle Sprains"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 21,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Ankle+Sprains&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T15:11:18.225Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03428620",
      "title": "Effect of Mobilization in Conjunction With Exercise in Participants With a History of Chronic Ankle Instability",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprains"
      ],
      "interventions": [
        {
          "name": "High Velocity Low Amplitude mobilization",
          "type": "OTHER"
        },
        {
          "name": "Exercise protocol",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Shenandoah University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 50,
      "start_date": "2018-02-14",
      "completion_date": "2019-06",
      "has_results": false,
      "last_update_posted_date": "2018-04-17",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 2,
      "location_summary": "Fayetteville, North Carolina • Winchester, Virginia",
      "locations": [
        {
          "city": "Fayetteville",
          "state": "North Carolina"
        },
        {
          "city": "Winchester",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03428620"
    },
    {
      "nct_id": "NCT06390072",
      "title": "Project Hypnos: The Impact of a Brief Hypnosis Intervention on Single-limb Dynamic Balance in People With Chronic Ankle Instability",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprains",
        "Motor Coordination or Function; Developmental Disorder"
      ],
      "interventions": [
        {
          "name": "Self-Hypnosis",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Ankle Education",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Ohio University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2023-09-25",
      "completion_date": "2023-11-27",
      "has_results": false,
      "last_update_posted_date": "2024-04-29",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 1,
      "location_summary": "Athens, Ohio",
      "locations": [
        {
          "city": "Athens",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06390072"
    },
    {
      "nct_id": "NCT04999904",
      "title": "A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Instability; Ankle (Ligaments) (Old Injury)",
        "Sprain of Ankle"
      ],
      "interventions": [
        {
          "name": "Uneven Treadmill Intervention",
          "type": "OTHER"
        },
        {
          "name": "Standard of Care Physical Therapy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Henry M. Jackson Foundation for the Advancement of Military Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "49 Years",
        "sex": "ALL",
        "summary": "18 Years to 49 Years"
      },
      "enrollment_count": 312,
      "start_date": "2021-11-23",
      "completion_date": "2026-09-30",
      "has_results": false,
      "last_update_posted_date": "2025-07-18",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 2,
      "location_summary": "Oceanside, California • San Diego, California",
      "locations": [
        {
          "city": "Oceanside",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04999904"
    },
    {
      "nct_id": "NCT01210612",
      "title": "The Effect of Five-Toed Socks on Postural Control Among Active Individuals Who Have Chronic Ankle Instabilities",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprain"
      ],
      "interventions": [
        {
          "name": "Unilateral CAI",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Toledo Health Science Campus",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 53,
      "start_date": "2010-09",
      "completion_date": "2010-12",
      "has_results": true,
      "last_update_posted_date": "2024-08-13",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 1,
      "location_summary": "Toledo, Ohio",
      "locations": [
        {
          "city": "Toledo",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01210612"
    },
    {
      "nct_id": "NCT01438905",
      "title": "Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprain"
      ],
      "interventions": [
        {
          "name": "Small amplitude (Grade IV) mobilization",
          "type": "OTHER"
        },
        {
          "name": "High velocity, low amplitude (Grade V) mobilization",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Creighton University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "45 Years",
        "sex": "MALE",
        "summary": "19 Years to 45 Years · Male only"
      },
      "enrollment_count": 30,
      "start_date": "2011-09",
      "completion_date": "2012-12",
      "has_results": false,
      "last_update_posted_date": "2018-02-23",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 1,
      "location_summary": "Omaha, Nebraska",
      "locations": [
        {
          "city": "Omaha",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01438905"
    },
    {
      "nct_id": "NCT03507803",
      "title": "Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Ankle Sprains",
        "Ankle Injuries"
      ],
      "interventions": [
        {
          "name": "Gait Biofeedback",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 60,
      "start_date": "2018-02-15",
      "completion_date": "2020-03",
      "has_results": false,
      "last_update_posted_date": "2018-05-16",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03507803"
    },
    {
      "nct_id": "NCT03918473",
      "title": "Effects of Mobilization Versus Manipulation on Function in Participants Reporting CAI",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprains"
      ],
      "interventions": [
        {
          "name": "Mobilization with Movement",
          "type": "OTHER"
        },
        {
          "name": "Thrust Mobilization",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Shenandoah University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 50,
      "start_date": "2019-04",
      "completion_date": "2020-12",
      "has_results": false,
      "last_update_posted_date": "2019-04-17",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 1,
      "location_summary": "Winchester, Virginia",
      "locations": [
        {
          "city": "Winchester",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03918473"
    },
    {
      "nct_id": "NCT06868316",
      "title": "Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprains",
        "Ankle Injuries and Disorders"
      ],
      "interventions": [
        {
          "name": "Walking",
          "type": "OTHER"
        },
        {
          "name": "Rucking",
          "type": "OTHER"
        },
        {
          "name": "Running",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Danielle Torp",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 100,
      "start_date": "2025-05-27",
      "completion_date": "2028-09",
      "has_results": false,
      "last_update_posted_date": "2026-07-21",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 2,
      "location_summary": "Lexington, Kentucky • Charlotte, North Carolina",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Charlotte",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06868316"
    },
    {
      "nct_id": "NCT00601471",
      "title": "Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprain",
        "Ankle Injuries",
        "Sprain"
      ],
      "interventions": [
        {
          "name": "proximal tibiofibular manipulation",
          "type": "OTHER"
        },
        {
          "name": "distal tibiofibular manipulation",
          "type": "OTHER"
        },
        {
          "name": "no intervention",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 61,
      "start_date": "2007-04",
      "completion_date": "2010-01",
      "has_results": false,
      "last_update_posted_date": "2010-06-24",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00601471"
    },
    {
      "nct_id": "NCT06484712",
      "title": "Electrical Stimulation Effect on Ankle Instability During Walking in Virtual Reality Setup",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ankle Sprains",
        "Ankle Instability"
      ],
      "interventions": [
        {
          "name": "Stochastic Resonance (SR)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Delaware",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "39 Years",
        "sex": "ALL",
        "summary": "18 Years to 39 Years"
      },
      "enrollment_count": 32,
      "start_date": "2024-05-29",
      "completion_date": "2025-01-09",
      "has_results": false,
      "last_update_posted_date": "2025-04-11",
      "last_synced_at": "2026-07-22T15:11:18.225Z",
      "location_count": 1,
      "location_summary": "Newark, Delaware",
      "locations": [
        {
          "city": "Newark",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06484712"
    }
  ]
}