{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Depressive+Disorder&page=2",
    "query": {
      "condition": "Chronic Depressive Disorder",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Depressive+Disorder&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-07-23T21:18:47.509Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04953806",
      "title": "The Development of an Integrated Physical Activity and Mental Health Intervention for Veterans With COPD, Emotion Distress, and Low Physical Activity",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "COPD",
        "Depression",
        "Anxiety"
      ],
      "interventions": [
        {
          "name": "Step-CBT",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2021-11-02",
      "completion_date": "2026-10-31",
      "has_results": false,
      "last_update_posted_date": "2026-06-03",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04953806"
    },
    {
      "nct_id": "NCT02868983",
      "title": "Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Arthritis",
        "Asthma",
        "Chronic Obstructive Lung Disease",
        "Diabetes",
        "Heart Failure",
        "Hypertension",
        "Anxiety",
        "Chronic Pain",
        "Depression",
        "Fibromyalgia",
        "Insomnia",
        "Irritable Bowel Syndrome",
        "Problem Drinking",
        "Substance Use Disorder"
      ],
      "interventions": [
        {
          "name": "Integration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4025,
      "start_date": "2016-04",
      "completion_date": "2021-09-30",
      "has_results": false,
      "last_update_posted_date": "2021-10-05",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 1,
      "location_summary": "Burlington, Vermont",
      "locations": [
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02868983"
    },
    {
      "nct_id": "NCT00006172",
      "title": "Clinical Trials of Two Non-drug Treatments for Chronic Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mood Disorders",
        "Depressive Disorders",
        "Depression",
        "Chronic Depression"
      ],
      "interventions": [
        {
          "name": "Bright light box",
          "type": "DEVICE"
        },
        {
          "name": "High-output negative ion generator",
          "type": "DEVICE"
        },
        {
          "name": "Low-output negative ion generator",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "New York State Psychiatric Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 32,
      "start_date": "2000-04",
      "completion_date": "2004-02",
      "has_results": false,
      "last_update_posted_date": "2014-10-01",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 2,
      "location_summary": "Middletown, Connecticut • New York, New York",
      "locations": [
        {
          "city": "Middletown",
          "state": "Connecticut"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00006172"
    },
    {
      "nct_id": "NCT01074515",
      "title": "Chronic Obstructive Pulmonary Disease (COPD) Activity: Serotonin Transporter (SERT), Cytokines and Depression (CASCADE Study)",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chronic Obstructive Pulmonary Disease"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "University of Washington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 350,
      "start_date": "2010-02",
      "completion_date": "2016-02",
      "has_results": false,
      "last_update_posted_date": "2015-12-03",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 4,
      "location_summary": "San Antonio, Texas • Seattle, Washington",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        },
        {
          "city": "Seattle",
          "state": "Washington"
        },
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01074515"
    },
    {
      "nct_id": "NCT05619510",
      "title": "Pain Reduction Through Empowered Recovery (PRIME) Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pain, Chronic",
        "Depressive Symptoms",
        "Depression",
        "Disability Physical"
      ],
      "interventions": [
        {
          "name": "PRIME Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "50 Years and older · Female only"
      },
      "enrollment_count": 9,
      "start_date": "2023-03-31",
      "completion_date": "2026-06-01",
      "has_results": false,
      "last_update_posted_date": "2026-06-05",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05619510"
    },
    {
      "nct_id": "NCT06049420",
      "title": "Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Hyperlipidemias",
        "Polycystic Ovary Syndrome",
        "Hypertension",
        "Coronary Heart Disease",
        "Heart Failure",
        "Depression, Anxiety",
        "Type II Diabetes",
        "Metabolic Syndrome"
      ],
      "interventions": [
        {
          "name": "Lifestyle counseling and coaching",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "West Virginia School of Osteopathic Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "18 Years to 64 Years"
      },
      "enrollment_count": 95,
      "start_date": "2025-02-01",
      "completion_date": "2027-09-01",
      "has_results": false,
      "last_update_posted_date": "2025-07-25",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 1,
      "location_summary": "Lewisburg, West Virginia",
      "locations": [
        {
          "city": "Lewisburg",
          "state": "West Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06049420"
    },
    {
      "nct_id": "NCT02938351",
      "title": "Collaborative Care Intervention for Chronic Kidney Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Kidney Transplant",
        "Depression",
        "Pain"
      ],
      "interventions": [
        {
          "name": "Collaborative care",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "21 Years to 95 Years"
      },
      "enrollment_count": 10,
      "start_date": "2016-06",
      "completion_date": "2021-03-01",
      "has_results": false,
      "last_update_posted_date": "2024-12-13",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02938351"
    },
    {
      "nct_id": "NCT00158275",
      "title": "Combined Interventions for Treating Depression and Chronic Back Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Back Pain",
        "Depression"
      ],
      "interventions": [
        {
          "name": "Cognitive behavioral therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Antidepressants",
          "type": "DRUG"
        },
        {
          "name": "Problem solving therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "Kaiser Permanente",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "74 Years",
        "sex": "ALL",
        "summary": "25 Years to 74 Years"
      },
      "enrollment_count": 71,
      "start_date": "2004-10",
      "completion_date": "2006-08",
      "has_results": false,
      "last_update_posted_date": "2017-10-13",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00158275"
    },
    {
      "nct_id": "NCT05194722",
      "title": "Optimizing Mental Health in Orthopedic Care",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anxiety",
        "Depression",
        "Back Pain",
        "Neck Pain"
      ],
      "interventions": [
        {
          "name": "Wysa mobile app",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2022-01-06",
      "completion_date": "2022-06-18",
      "has_results": true,
      "last_update_posted_date": "2026-02-17",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05194722"
    },
    {
      "nct_id": "NCT00220701",
      "title": "Escitalopram in the Treatment of Dysthymic Disorder, Double Blind",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Dysthymic Disorder"
      ],
      "interventions": [
        {
          "name": "Lexapro (escitalopram)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "St. Luke's-Roosevelt Hospital Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 36,
      "start_date": "2002-06",
      "completion_date": "2009-01",
      "has_results": true,
      "last_update_posted_date": "2015-11-11",
      "last_synced_at": "2026-07-23T21:18:47.509Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00220701"
    }
  ]
}