{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Limb+Threatening+Ischemia&page=2",
    "query": {
      "condition": "Chronic Limb Threatening Ischemia",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Limb+Threatening+Ischemia&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T15:45:12.550Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02786173",
      "title": "Peripheral Registry of Endovascular Clinical Outcomes \"The PRIME Registry\"",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Peripheral Arterial Disease",
        "Peripheral Vascular Disease",
        "Critical Limb Ischemia"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Metro Health, Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1000,
      "start_date": "2013-01",
      "completion_date": "2021-11-05",
      "has_results": false,
      "last_update_posted_date": "2023-03-13",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 6,
      "location_summary": "Orlando, Florida • Springfield, Illinois • Wyoming, Michigan + 3 more",
      "locations": [
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Springfield",
          "state": "Illinois"
        },
        {
          "city": "Wyoming",
          "state": "Michigan"
        },
        {
          "city": "Springfield",
          "state": "Missouri"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02786173"
    },
    {
      "nct_id": "NCT05161039",
      "title": "Serranator Recoil Study",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Peripheral Arterial Disease",
        "Critical Limb Ischemia"
      ],
      "interventions": [
        {
          "name": "Serranator",
          "type": "DEVICE"
        },
        {
          "name": "POBA",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Cagent Vascular LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2021-11-15",
      "completion_date": "2022-07",
      "has_results": false,
      "last_update_posted_date": "2022-06-09",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05161039"
    },
    {
      "nct_id": "NCT00059657",
      "title": "Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Peripheral Vascular Disease"
      ],
      "interventions": [
        {
          "name": "Ecraprost in lipid emulsion",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Tanabe Pharma Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 280,
      "start_date": "2001-08",
      "completion_date": "2005-11",
      "has_results": false,
      "last_update_posted_date": "2006-05-19",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 15,
      "location_summary": "Phoenix, Arizona • Tucson, Arizona • Glendale, California + 12 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Glendale",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00059657"
    },
    {
      "nct_id": "NCT06434194",
      "title": "Serrantor OCT Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Limb Ischemia"
      ],
      "interventions": [
        {
          "name": "Serranator PTA Serration Catheter",
          "type": "DEVICE"
        },
        {
          "name": "PTA (Standard of Care)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Cagent Vascular LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2024-10-31",
      "completion_date": "2025-06-01",
      "has_results": false,
      "last_update_posted_date": "2025-05-18",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 2,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06434194"
    },
    {
      "nct_id": "NCT02234778",
      "title": "Evaluation of the Tissue Genesis® Icellator Cell Isolation System™ to Treat Critical Limb Ischemia",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Limb Ischemia"
      ],
      "interventions": [
        {
          "name": "TGI SVF material via intramuscular injection",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Tissue Genesis",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2014-08",
      "completion_date": "2023-10",
      "has_results": false,
      "last_update_posted_date": "2021-06-24",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02234778"
    },
    {
      "nct_id": "NCT00189540",
      "title": "Study of Hepatocyte Growth Factor (HGF) Via Plasmid Vector to Improve Perfusion in Critical Limb Ischemia Patients With Peripheral Ischemic Ulcers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Arterial Occlusive Disease",
        "Peripheral Vascular Disease",
        "Ischemia",
        "Ulcers"
      ],
      "interventions": [
        {
          "name": "HGF plasmid",
          "type": "GENETIC"
        },
        {
          "name": "Placebo",
          "type": "GENETIC"
        }
      ],
      "intervention_types": [
        "GENETIC"
      ],
      "sponsor": "AnGes USA, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 27,
      "start_date": "2005-08",
      "completion_date": "2008-08",
      "has_results": true,
      "last_update_posted_date": "2021-10-28",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 4,
      "location_summary": "Pensacola, Florida • Indianapolis, Indiana • Boston, Massachusetts + 1 more",
      "locations": [
        {
          "city": "Pensacola",
          "state": "Florida"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Lebanon",
          "state": "New Hampshire"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00189540"
    },
    {
      "nct_id": "NCT03253328",
      "title": "N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Diabetes Mellitus",
        "Critical Limb Ischemia",
        "Lower Limb Amputation Knee",
        "Peripheral Arterial Disease"
      ],
      "interventions": [
        {
          "name": "Active Arm N-acetyl cysteine (NAC)",
          "type": "DRUG"
        },
        {
          "name": "Placebo Arm",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "30 Years to 90 Years"
      },
      "enrollment_count": 33,
      "start_date": "2017-03-01",
      "completion_date": "2022-06-27",
      "has_results": true,
      "last_update_posted_date": "2024-08-16",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03253328"
    },
    {
      "nct_id": "NCT00392509",
      "title": "ALD-301 for Critical Limb Ischemia, Randomized Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Critical Limb Ischemia",
        "Peripheral Arterial Disease",
        "Peripheral Vascular Disease"
      ],
      "interventions": [
        {
          "name": "ALDH-br bone marrow cells vs. mononuclear bone marrow cells",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Aldagen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2006-10",
      "completion_date": "2008-12",
      "has_results": false,
      "last_update_posted_date": "2009-05-14",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 5,
      "location_summary": "Birmingham, Alabama • Atlanta, Georgia • Indianapolis, Indiana + 2 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00392509"
    },
    {
      "nct_id": "NCT00041925",
      "title": "Prevention of Autogenous Vein Graft Failure in Peripheral Artery Bypass Procedures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Peripheral Vascular Diseases",
        "Arterial Occlusive Diseases",
        "Ischemia",
        "Graft Occlusion, Vascular",
        "Hyperplasia"
      ],
      "interventions": [
        {
          "name": "CGT003 (E2F Duplex Decoy)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Anesiva, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1400,
      "start_date": "2001-11",
      "completion_date": "2004-11",
      "has_results": false,
      "last_update_posted_date": "2005-07-15",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 116,
      "location_summary": "Birmingham, Alabama • Mobile, Alabama • Tucson, Arizona + 61 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00041925"
    },
    {
      "nct_id": "NCT01019681",
      "title": "Efficacy and Safety of Umbilical Cord Blood Injection for Critical Limb Ischemia",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Critical Limb Ischemia"
      ],
      "interventions": [
        {
          "name": "Cord blood stem cell injection",
          "type": "BIOLOGICAL"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL"
      ],
      "sponsor": "Richard Burt, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "72 Years",
        "sex": "ALL",
        "summary": "18 Years to 72 Years"
      },
      "enrollment_count": 1,
      "start_date": "2009-11",
      "completion_date": "2014-01",
      "has_results": false,
      "last_update_posted_date": "2014-02-03",
      "last_synced_at": "2026-06-10T15:45:12.550Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01019681"
    }
  ]
}