{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Orthostatic+Intolerance&page=2",
    "query": {
      "condition": "Chronic Orthostatic Intolerance",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Orthostatic+Intolerance&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-05-22T09:05:50.092Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01399489",
      "title": "Aerobic Training and Arterial Stiffness in Chronic Kidney Disease (CKD) Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Kidney Disease",
        "Hypertension",
        "Diabetes"
      ],
      "interventions": [
        {
          "name": "Exercise training",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Springfield College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "35 Years to 70 Years"
      },
      "enrollment_count": 51,
      "start_date": "2009-09",
      "completion_date": "2012-12",
      "has_results": false,
      "last_update_posted_date": "2014-01-23",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "Springfield, Massachusetts",
      "locations": [
        {
          "city": "Springfield",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01399489"
    },
    {
      "nct_id": "NCT06156202",
      "title": "Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program for PASC Program to Improve Functioning of Persons Suffering From Post-COVID-19 Syndrome: A Randomized Controlled Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post-Acute COVID-19",
        "Post-Acute COVID-19 Syndrome",
        "Post-Acute COVID-19 Infection",
        "Long COVID",
        "Long Covid19",
        "Dyspnea",
        "Orthostasis",
        "Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Comprehensive Rehabilitation",
          "type": "OTHER"
        },
        {
          "name": "Augmented Usual Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 125,
      "start_date": "2023-11-15",
      "completion_date": "2025-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-01-20",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06156202"
    },
    {
      "nct_id": "NCT06133075",
      "title": "Using Mirabegron to Increase BP in Patients With POTS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Postural Orthostatic Tachycardia Syndrome",
        "Chronic Orthostatic Intolerance",
        "Syncope"
      ],
      "interventions": [
        {
          "name": "Mirabegron 50 MG",
          "type": "DRUG"
        },
        {
          "name": "Mirabegron 25 MG",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2023-12-22",
      "completion_date": "2025-07-25",
      "has_results": true,
      "last_update_posted_date": "2026-04-08",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06133075"
    },
    {
      "nct_id": "NCT05664711",
      "title": "Effect of Stellate Ganglion Block on ME/CFS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Encephalomyelitis, Myalgic",
        "Chronic Fatigue Syndrome",
        "Chronic Fatigue Disorder",
        "Chronic Fatigue and Immune Dysfunction Syndrome",
        "Myalgic Encephalomyelitis",
        "Postviral Fatigue Syndrome",
        "Systemic Exertion Intolerance Disease",
        "Infectious Mononucleosis-Like Syndrome, Chronic",
        "Chronic Fatigue-Fibromyalgia Syndrome"
      ],
      "interventions": [
        {
          "name": "Bupivacaine Injection",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Neuroversion, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 50 Years · Female only"
      },
      "enrollment_count": 10,
      "start_date": "2023-03-15",
      "completion_date": "2024-01-15",
      "has_results": false,
      "last_update_posted_date": "2024-12-06",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "Anchorage, Alaska",
      "locations": [
        {
          "city": "Anchorage",
          "state": "Alaska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05664711"
    },
    {
      "nct_id": "NCT04140721",
      "title": "Autonomic Determinants of POTS - Pilot 2",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Postural Tachycardia Syndrome"
      ],
      "interventions": [
        {
          "name": "Placebo oral tablet",
          "type": "DRUG"
        },
        {
          "name": "Moxonidine Pill",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 48,
      "start_date": "2021-08-31",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-27",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04140721"
    },
    {
      "nct_id": "NCT05725499",
      "title": "The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injuries",
        "Hypotension",
        "Orthostatic Hypotension",
        "Spinal Cord Diseases",
        "Cardiovascular Diseases",
        "Trauma, Nervous System",
        "Central Nervous System Diseases",
        "Nervous System Diseases",
        "Blood Pressure"
      ],
      "interventions": [
        {
          "name": "Biostim-5 transcutaneous spinal stimulator",
          "type": "DEVICE"
        },
        {
          "name": "Tilt-table orthostatic stress testing",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Kessler Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 5,
      "start_date": "2023-02-01",
      "completion_date": "2026-08-01",
      "has_results": false,
      "last_update_posted_date": "2025-09-02",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "West Orange, New Jersey",
      "locations": [
        {
          "city": "West Orange",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05725499"
    },
    {
      "nct_id": "NCT06027255",
      "title": "Long COVID Immune Profiling",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Long COVID",
        "POTS - Postural Orthostatic Tachycardia Syndrome",
        "Autonomic Dysfunction"
      ],
      "interventions": [
        {
          "name": "IL-6",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "cytokines (IL-17, and IFN-ɣ)",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Compass 31",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST",
        "BEHAVIORAL"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2024-04-24",
      "completion_date": "2027-07-01",
      "has_results": false,
      "last_update_posted_date": "2025-12-15",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06027255"
    },
    {
      "nct_id": "NCT04141891",
      "title": "Advancing Understanding of Transportation Options",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetic Retinopathy",
        "Macular Degeneration",
        "Glaucoma",
        "Retinitis Pigmentosa",
        "Vision Disorders",
        "Acute Coronary Syndrome",
        "Implantable Defibrillator User",
        "Congestive Heart Failure",
        "Hypertrophic Obstructive Cardiomyopathy",
        "Orthostatic Hypotension",
        "Syncope",
        "Presyncope",
        "Narcolepsy",
        "Dementia",
        "Multiple Sclerosis",
        "Parkinson Disease",
        "Brain Injuries",
        "Spinal Cord Injuries",
        "Stroke",
        "Vertigo",
        "Dizziness",
        "Seizures",
        "Substance Use",
        "Insulin Dependent Diabetes Mellitus",
        "Arthritis",
        "Foot--Abnormalities",
        "Chronic Obstructive Pulmonary Disease",
        "Obstructive Sleep Apnea",
        "End Stage Renal Disease",
        "Sleep Apnea",
        "Insomnia",
        "Restless Legs Syndrome"
      ],
      "interventions": [
        {
          "name": "Driving Decision Aid",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Older Drivers Website",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 529,
      "start_date": "2019-12-12",
      "completion_date": "2023-12-21",
      "has_results": true,
      "last_update_posted_date": "2025-02-21",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 3,
      "location_summary": "La Jolla, California • Aurora, Colorado • Indianapolis, Indiana",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04141891"
    },
    {
      "nct_id": "NCT03674541",
      "title": "The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome",
        "Chronic Fatigue Syndrome",
        "Myalgic Encephalomyelitis",
        "Exercise Intolerance",
        "Dysautonomia",
        "Low Ventricular Filling Pressures (Preload Failure)",
        "Postural Orthostatic Tachycardia Syndrome",
        "Orthostatic Hypotension",
        "Fibromyalgia"
      ],
      "interventions": [
        {
          "name": "Pyridostigmine Bromide",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Brigham and Women's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 45,
      "start_date": "2020-01-14",
      "completion_date": "2021-12-20",
      "has_results": true,
      "last_update_posted_date": "2022-11-08",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03674541"
    },
    {
      "nct_id": "NCT05421208",
      "title": "Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Post-acute COVID-19 Syndrome",
        "Postural Tachycardia Syndrome (POTS)",
        "Long COVID",
        "SARS CoV 2 Infection"
      ],
      "interventions": [
        {
          "name": "Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Levels of inflammatory cytokine ( IL-6) in controls",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Effect on inflammation after chronic PNS stimulation",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 60,
      "start_date": "2022-06-01",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-01-20",
      "last_synced_at": "2026-05-22T09:05:50.092Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05421208"
    }
  ]
}