{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Total+Occlusion+%28CTO%29",
    "query": {
      "condition": "Chronic Total Occlusion (CTO)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 23,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Chronic+Total+Occlusion+%28CTO%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-22T06:04:31.081Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02145299",
      "title": "The Lumen Study: Comparing Devices for Patients With Symptomatic Femoro-popliteal Chronic Total Occlusion (CTO)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Symptomatic Femoro-popliteal Chronic Total Occlusion"
      ],
      "interventions": [
        {
          "name": "TruePath CTO Device",
          "type": "DEVICE"
        },
        {
          "name": "CROSSER CTO Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 8,
      "start_date": "2014-05",
      "completion_date": "2015-06",
      "has_results": true,
      "last_update_posted_date": "2016-11-04",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02145299"
    },
    {
      "nct_id": "NCT01435031",
      "title": "EXPERT CTO: Evaluation of the XIENCE PRIME™ LL and XIENCE Nano™ Everolimus Eluting Coronary Stent Coronary Stents, Performance, and Technique in Chronic Total Occlusions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Artery Disease (CAD)",
        "Chronic Total Occlusion (CTO)"
      ],
      "interventions": [
        {
          "name": "CTO Treatment Device",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Abbott Medical Devices",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 250,
      "start_date": "2011-09",
      "completion_date": "2017-12",
      "has_results": true,
      "last_update_posted_date": "2018-05-09",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 1,
      "location_summary": "Santa Clara, California",
      "locations": [
        {
          "city": "Santa Clara",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01435031"
    },
    {
      "nct_id": "NCT06795763",
      "title": "Acolyte CTO-PCI Study: Imaging and Catheter System to Treat Patients With Coronary Chronic Total Occlusion, Who Have Persistent Symptoms Following Medical Therapy and Are Undergoing Percutaneous Coronary Interventional Procedures",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Chronic Total Occlusions",
        "Ischemic Heart Disease",
        "Ischemic Heart Disease (IHD)",
        "Ischemic Heart Disease Chronic"
      ],
      "interventions": [
        {
          "name": "CTO-PCI Procedure with Acolyte Catheter System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Elumn8 Medical",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 115,
      "start_date": "2025-08-06",
      "completion_date": "2027-09-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-19",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 5,
      "location_summary": "Atlanta, Georgia • Minneapolis, Minnesota • Roslyn, New York + 1 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Roslyn",
          "state": "New York"
        },
        {
          "city": "Amarillo",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06795763"
    },
    {
      "nct_id": "NCT00459446",
      "title": "Imaging of Totally Blocked Arteries",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Atherosclerosis",
        "Peripheral Artery Disease",
        "Intermittent Claudication",
        "Chronic Total Aterial Occlusion"
      ],
      "interventions": [
        {
          "name": "MS-325 Injection (Gadofosveset Trisodium)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2007-04-05",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2017-07-02",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00459446"
    },
    {
      "nct_id": "NCT05089864",
      "title": "STAR and Deferred Stenting Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Occlusion",
        "Coronary Stenosis",
        "Coronary Restenosis"
      ],
      "interventions": [
        {
          "name": "Stent Placement Timing - Early",
          "type": "OTHER"
        },
        {
          "name": "Stent Placement Timing - Late",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Saint Luke's Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2021-11-23",
      "completion_date": "2025-08-07",
      "has_results": false,
      "last_update_posted_date": "2025-10-24",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 1,
      "location_summary": "Kansas City, Missouri",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05089864"
    },
    {
      "nct_id": "NCT05440084",
      "title": "Impact of CTO PCI (Chronic Total Occlusion Percutaneous Intervention) on Regular Physical Activity",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chronic Total Occlusion",
        "Occlusion"
      ],
      "interventions": [
        {
          "name": "Chronic total occlusion percutaneous coronary intervention",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Minneapolis Heart Institute Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1,
      "start_date": "2022-09-01",
      "completion_date": "2024-09-01",
      "has_results": false,
      "last_update_posted_date": "2025-01-24",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05440084"
    },
    {
      "nct_id": "NCT02026466",
      "title": "Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Saint Luke's Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1000,
      "start_date": "2013-12",
      "completion_date": "2017-12",
      "has_results": false,
      "last_update_posted_date": "2021-10-19",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 11,
      "location_summary": "Mesa, Arizona • Phoenix, Arizona • Torrance, California + 8 more",
      "locations": [
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Torrance",
          "state": "California"
        },
        {
          "city": "Elk Grove Village",
          "state": "Illinois"
        },
        {
          "city": "Columbia",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02026466"
    },
    {
      "nct_id": "NCT03521804",
      "title": "Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Chronic Total Occlusion of Coronary Artery"
      ],
      "interventions": [
        {
          "name": "SoundBite™ Crossing System Active Wire 14",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "SoundBite Medical Solutions, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 35,
      "start_date": "2018-06-21",
      "completion_date": "2020-11-20",
      "has_results": false,
      "last_update_posted_date": "2023-12-06",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03521804"
    },
    {
      "nct_id": "NCT03118544",
      "title": "REduction of Contrast Via DyeVert Used in CTO Procedures",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Chronic Total Occlusion of Coronary Artery"
      ],
      "interventions": [
        {
          "name": "DyeVert System",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Minneapolis Heart Institute Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2017-03-26",
      "completion_date": "2018-02-02",
      "has_results": false,
      "last_update_posted_date": "2018-05-17",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 3,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03118544"
    },
    {
      "nct_id": "NCT02499666",
      "title": "Change in Exercise Capacity as Measured by Peak Oxygen Uptake After CTO PCI",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Coronary Artery Disease",
        "Angina Pectoris"
      ],
      "interventions": [
        {
          "name": "Percutaneous Coronary Intervention",
          "type": "PROCEDURE"
        },
        {
          "name": "Coronary stent",
          "type": "DEVICE"
        },
        {
          "name": "Clopidogrel",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE",
        "DRUG"
      ],
      "sponsor": "Henry Ford Health System",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "18 Years to 90 Years"
      },
      "enrollment_count": 15,
      "start_date": "2015-06-29",
      "completion_date": "2017-10-30",
      "has_results": false,
      "last_update_posted_date": "2022-03-07",
      "last_synced_at": "2026-07-22T06:04:31.081Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02499666"
    }
  ]
}