{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Circulatory+Stress&page=5",
    "query": {
      "condition": "Circulatory Stress",
      "page": 5
    },
    "page_size": 10
  },
  "pagination": {
    "page": 5,
    "page_size": 10,
    "total_count": 489,
    "total_pages": 49,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Circulatory+Stress&page=6&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Circulatory+Stress&page=4&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-06T09:55:33.913Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02492269",
      "title": "Stress Response and Neurodevelopmental Outcome After Cardiac Surgery Utilizing CPB in Children: A Prospective, Double Blinded and Randomized Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Congenital Heart Disease"
      ],
      "interventions": [
        {
          "name": "Dexmedetomidine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Aymen N Naguib",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Month",
        "maximum_age": "12 Months",
        "sex": "ALL",
        "summary": "1 Month to 12 Months"
      },
      "enrollment_count": 30,
      "start_date": "2014-05",
      "completion_date": "2024-12",
      "has_results": true,
      "last_update_posted_date": "2025-08-07",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02492269"
    },
    {
      "nct_id": "NCT03988621",
      "title": "Improving Self-care of Heart Failure Caregivers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Heart Failure"
      ],
      "interventions": [
        {
          "name": "ViCCY",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 343,
      "start_date": "2019-08-23",
      "completion_date": "2023-10-19",
      "has_results": true,
      "last_update_posted_date": "2025-02-20",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03988621"
    },
    {
      "nct_id": "NCT00681200",
      "title": "Evaluating Mechanisms of Blood Pressure Reduction Using Meditation in Hypertensive African Americans",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "Enhanced health education",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Transcendental Meditation program",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Maharishi International University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 152,
      "start_date": "2008-04",
      "completion_date": "2012-05",
      "has_results": false,
      "last_update_posted_date": "2022-04-14",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 1,
      "location_summary": "Washington D.C., District of Columbia",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00681200"
    },
    {
      "nct_id": "NCT01798992",
      "title": "Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Idiopathic Dilated Cardiomyopathy"
      ],
      "interventions": [
        {
          "name": "Carvedilol",
          "type": "DRUG"
        },
        {
          "name": "Metoprolol succinate",
          "type": "DRUG"
        },
        {
          "name": "Metoprolol succinate + doxazosin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 56,
      "start_date": "2000-09",
      "completion_date": "2009-03",
      "has_results": true,
      "last_update_posted_date": "2023-11-29",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 2,
      "location_summary": "Denver, Colorado • Salt Lake City, Utah",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01798992"
    },
    {
      "nct_id": "NCT01411293",
      "title": "Vasoprotective Activities of Low-Fat Milk in Individuals With Metabolic Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiovascular Disease",
        "Metabolic Syndrome",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Low-Fat Milk",
          "type": "OTHER"
        },
        {
          "name": "Rice Milk",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Connecticut",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 21,
      "start_date": "2011-08",
      "completion_date": "2013-10",
      "has_results": false,
      "last_update_posted_date": "2014-01-06",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 1,
      "location_summary": "Storrs, Connecticut",
      "locations": [
        {
          "city": "Storrs",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01411293"
    },
    {
      "nct_id": "NCT01545492",
      "title": "Testing the Developmental Origins Hypothesis",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Diabetes",
        "Stroke",
        "Obesity"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Children's & Women's Health Centre of British Columbia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 626,
      "start_date": "2012-01",
      "completion_date": "2019-01",
      "has_results": false,
      "last_update_posted_date": "2012-03-06",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 4,
      "location_summary": "New Haven, Connecticut • Louisville, Kentucky • Camden, New Jersey + 1 more",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Louisville",
          "state": "Kentucky"
        },
        {
          "city": "Camden",
          "state": "New Jersey"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01545492"
    },
    {
      "nct_id": "NCT02522481",
      "title": "Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-141",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Coronary Artery Disease"
      ],
      "interventions": [
        {
          "name": "Lumason",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bracco Diagnostics, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 175,
      "start_date": "2015-09-24",
      "completion_date": "2018-02-25",
      "has_results": true,
      "last_update_posted_date": "2021-06-11",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 10,
      "location_summary": "Tucson, Arizona • La Jolla, California • West Hills, California + 7 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "West Hills",
          "state": "California"
        },
        {
          "city": "Newark",
          "state": "Delaware"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02522481"
    },
    {
      "nct_id": "NCT02546726",
      "title": "Heat & Aerobic Training (HEAT) Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pre-hypertension"
      ],
      "interventions": [
        {
          "name": "Heat & Aerobic Training (HEAT)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Exercise Only",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Illinois at Urbana-Champaign",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "45 Years to 64 Years"
      },
      "enrollment_count": 41,
      "start_date": "2015-08-21",
      "completion_date": "2017-05-24",
      "has_results": false,
      "last_update_posted_date": "2019-04-17",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 1,
      "location_summary": "Urbana, Illinois",
      "locations": [
        {
          "city": "Urbana",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02546726"
    },
    {
      "nct_id": "NCT01432626",
      "title": "Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Stress Induced Cardiomyopathy"
      ],
      "interventions": [
        {
          "name": "I-123 radiolabeled metaiodobenzylguanidine cardiac imaging",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2011-09",
      "completion_date": "2015-06",
      "has_results": true,
      "last_update_posted_date": "2016-03-22",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01432626"
    },
    {
      "nct_id": "NCT03680404",
      "title": "The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cardiovascular Diseases",
        "Cardiovascular Risk Factor",
        "Vasoconstriction"
      ],
      "interventions": [
        {
          "name": "Control (Phenylephrine)",
          "type": "DRUG"
        },
        {
          "name": "Phenylephrine + Apocynin",
          "type": "DRUG"
        },
        {
          "name": "Phenylephrine + Allopurinol",
          "type": "DRUG"
        },
        {
          "name": "Phenylephrine + Tempol",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas at Arlington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 24,
      "start_date": "2018-10-01",
      "completion_date": "2020-02-01",
      "has_results": false,
      "last_update_posted_date": "2020-11-05",
      "last_synced_at": "2026-10-06T09:55:33.913Z",
      "location_count": 1,
      "location_summary": "Arlington, Texas",
      "locations": [
        {
          "city": "Arlington",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03680404"
    }
  ]
}