{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Clinical+High-Risk&page=12",
    "query": {
      "condition": "Clinical High-Risk",
      "page": 12
    },
    "page_size": 10
  },
  "pagination": {
    "page": 12,
    "page_size": 10,
    "total_count": 455,
    "total_pages": 46,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Clinical+High-Risk&page=13&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Clinical+High-Risk&page=11&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-23T05:31:15.842Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06329544",
      "title": "High Fructose Diet, the Gut Microbiome, and Metabolic Health",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "MASLD",
        "Type 2 Diabetes",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Fructose",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "glucose",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Icahn School of Medicine at Mount Sinai",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "25 Years to 45 Years"
      },
      "enrollment_count": 30,
      "start_date": "2024-10-08",
      "completion_date": "2028-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-12-17",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06329544"
    },
    {
      "nct_id": "NCT07490067",
      "title": "Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Heart Failure With Reduced Ejection Fraction"
      ],
      "interventions": [
        {
          "name": "Metoprolol Succinate",
          "type": "DRUG"
        },
        {
          "name": "Beta-Blocker Polygenic Score",
          "type": "DEVICE"
        },
        {
          "name": "Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2026-12",
      "completion_date": "2029-07",
      "has_results": false,
      "last_update_posted_date": "2026-10-15",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07490067"
    },
    {
      "nct_id": "NCT02200328",
      "title": "Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Clostridium Difficile Diarrhea"
      ],
      "interventions": [
        {
          "name": "Metronidazole",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Alison Schneider",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "55 Years and older"
      },
      "enrollment_count": 76,
      "start_date": "2014-08",
      "completion_date": "2016-03",
      "has_results": true,
      "last_update_posted_date": "2017-05-17",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 1,
      "location_summary": "Weston, Florida",
      "locations": [
        {
          "city": "Weston",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02200328"
    },
    {
      "nct_id": "NCT06932341",
      "title": "Evaluation of the Impact of EHR-Alerts on Clinical Decision Support Pathway Use in Bronchiolitis, and the Impact of Pathway Use on the Prescription of High Flow Nasal Cannula and Other Elements of High Value Care.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bronchiolitis"
      ],
      "interventions": [
        {
          "name": "Non-interruptive",
          "type": "OTHER"
        },
        {
          "name": "Interruptive",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "24 Months",
        "sex": "ALL",
        "summary": "Up to 24 Months"
      },
      "enrollment_count": 2965,
      "start_date": "2025-05-05",
      "completion_date": "2026-07-12",
      "has_results": false,
      "last_update_posted_date": "2026-07-17",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 3,
      "location_summary": "St. Petersburg, Florida • Baltimore, Maryland",
      "locations": [
        {
          "city": "St. Petersburg",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06932341"
    },
    {
      "nct_id": "NCT00267254",
      "title": "A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Hyperlipidemia",
        "Dyslipidemia",
        "Hypercholesterolemia"
      ],
      "interventions": [
        {
          "name": "torcetrapib/atorvastatin",
          "type": "DRUG"
        },
        {
          "name": "simvastatin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pfizer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 640,
      "start_date": "2006-01",
      "completion_date": "2006-08",
      "has_results": false,
      "last_update_posted_date": "2007-11-21",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 49,
      "location_summary": "Birmingham, Alabama • Mobile, Alabama • Mesa, Arizona + 46 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Mobile",
          "state": "Alabama"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tempe",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00267254"
    },
    {
      "nct_id": "NCT00039676",
      "title": "Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Hematologic Cancer",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Waldenstrom Macroglobulinemia",
        "Chronic Lymphocytic Leukemia",
        "Hodgkin Disease",
        "NonHodgkin Lymphoma",
        "Mixed Lymphoproliferative Disease"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "National Cancer Institute (NCI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "11 Months",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "11 Months and older"
      },
      "enrollment_count": 1836,
      "start_date": "2002-07-08",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2026-10-13",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 2,
      "location_summary": "Bethesda, Maryland • Rockville, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        },
        {
          "city": "Rockville",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00039676"
    },
    {
      "nct_id": "NCT05440851",
      "title": "Platform of Randomized Adaptive Clinical Trials in Critical Illness",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Insufficiency",
        "Extracorporeal Membrane Oxygenation Complication",
        "Mechanical Ventilation Pressure High"
      ],
      "interventions": [
        {
          "name": "Ultra-Protective Ventilation Facilitated by Extracorporeal Support",
          "type": "OTHER"
        },
        {
          "name": "Lung-Protective Ventilation (LPV)",
          "type": "OTHER"
        },
        {
          "name": "Driving Pressure-Limited Ventilation (DPL)",
          "type": "OTHER"
        },
        {
          "name": "Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)",
          "type": "OTHER"
        },
        {
          "name": "Early Cohort corticosteroid dose",
          "type": "DRUG"
        },
        {
          "name": "Extended Cohort corticosteroid dose",
          "type": "DRUG"
        },
        {
          "name": "Usual care without routine corticosteroids",
          "type": "DRUG"
        },
        {
          "name": "Usual care without extending corticosteroids",
          "type": "DRUG"
        },
        {
          "name": "Usual care with fludrocortisone",
          "type": "DRUG"
        },
        {
          "name": "Usual care without fludrocortisone",
          "type": "DRUG"
        },
        {
          "name": "Drug 4 mL:",
          "type": "DRUG"
        },
        {
          "name": "Drug 40 mg:",
          "type": "DRUG"
        },
        {
          "name": "PEEP-20",
          "type": "OTHER"
        },
        {
          "name": "PEEP-AOP",
          "type": "OTHER"
        },
        {
          "name": "PEEP-10",
          "type": "OTHER"
        },
        {
          "name": "VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation",
          "type": "OTHER"
        },
        {
          "name": "Electrical impedance tomography (EIT)",
          "type": "OTHER"
        },
        {
          "name": "no treatment / intervention arm is involved.",
          "type": "OTHER"
        },
        {
          "name": "Usual care",
          "type": "OTHER"
        },
        {
          "name": "Early Routine IMT",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "University Health Network, Toronto",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6250,
      "start_date": "2023-04-30",
      "completion_date": "2027-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-10-22",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 27,
      "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 20 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05440851"
    },
    {
      "nct_id": "NCT00192439",
      "title": "Study to Evaluate the Human Infection of the Lower Respiratory Tract in Children at High Risk",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Severe Respiratory Disease"
      ],
      "interventions": [
        {
          "name": "High Risk Respiratory Disease",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "MedImmune LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "24 Months",
        "sex": "ALL",
        "summary": "1 Day to 24 Months"
      },
      "enrollment_count": 1500,
      "start_date": "2003-12",
      "completion_date": "2006-12",
      "has_results": false,
      "last_update_posted_date": "2007-05-07",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 16,
      "location_summary": "Long Beach, California • Denver, Colorado • Chicago, Illinois + 13 more",
      "locations": [
        {
          "city": "Long Beach",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00192439"
    },
    {
      "nct_id": "NCT01252329",
      "title": "Comparison of Elective Lymph Node Treatment Versus Clinical Observation in the Absence of Palpable Lymph Nodes for High Risk Skin Squamous Cell Carcinoma (SCC)",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "High Risk Cutaneous Squamous Cell Carcinoma"
      ],
      "interventions": [
        {
          "name": "elective lymph node dissection",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 29,
      "start_date": "2011-04",
      "completion_date": "2014-07-14",
      "has_results": false,
      "last_update_posted_date": "2017-10-24",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 2,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01252329"
    },
    {
      "nct_id": "NCT03240770",
      "title": "Effect of VPro5 Therapy on Clear Aligner Therapy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Malocclusion"
      ],
      "interventions": [
        {
          "name": "VPro5 device",
          "type": "DEVICE"
        },
        {
          "name": "Deviation from Standard Tray Wear Time (14 Days)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Mani Alikhani",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 60,
      "start_date": "2017-02-03",
      "completion_date": "2017-07-20",
      "has_results": false,
      "last_update_posted_date": "2017-08-07",
      "last_synced_at": "2026-10-23T05:31:15.842Z",
      "location_count": 4,
      "location_summary": "Hoboken, New Jersey • Brooklyn, New York • San Antonio, Texas",
      "locations": [
        {
          "city": "Hoboken",
          "state": "New Jersey"
        },
        {
          "city": "Hoboken",
          "state": "New Jersey"
        },
        {
          "city": "Brooklyn",
          "state": "New York"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03240770"
    }
  ]
}