{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cognitive+Changes&page=4",
    "query": {
      "condition": "Cognitive Changes",
      "page": 4
    },
    "page_size": 10
  },
  "pagination": {
    "page": 4,
    "page_size": 10,
    "total_count": 334,
    "total_pages": 34,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cognitive+Changes&page=5&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cognitive+Changes&page=3&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-23T00:00:39.406Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01208324",
      "title": "Estrogen and Serotonin on Changing Brain Chemistry",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Menopause"
      ],
      "interventions": [
        {
          "name": "estrogen patch",
          "type": "DRUG"
        },
        {
          "name": "Amino acids",
          "type": "DRUG"
        },
        {
          "name": "Placebo Patch",
          "type": "DRUG"
        },
        {
          "name": "Placebo pills",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "48 Years",
        "maximum_age": "60 Years",
        "sex": "FEMALE",
        "summary": "48 Years to 60 Years · Female only"
      },
      "enrollment_count": 47,
      "start_date": "2010-03-04",
      "completion_date": "2018-11",
      "has_results": true,
      "last_update_posted_date": "2021-04-02",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01208324"
    },
    {
      "nct_id": "NCT06062186",
      "title": "Acute Effects of Naturally Occurring Tea and Coffee-based Ingredients on Cognitive Performance",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognitive Change"
      ],
      "interventions": [
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "AmaTea Guayusa Extract",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Lion's Mane",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "The Center for Applied Health Sciences, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 40,
      "start_date": "2023-04-05",
      "completion_date": "2023-09-15",
      "has_results": false,
      "last_update_posted_date": "2023-10-02",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 1,
      "location_summary": "Canfield, Ohio",
      "locations": [
        {
          "city": "Canfield",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06062186"
    },
    {
      "nct_id": "NCT05201534",
      "title": "Interventions in Mathematics and Cognitive Skills",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Math Learning Disability",
        "Child Development",
        "Developmental Disability",
        "Learning Disabilities",
        "Learning Disabled",
        "Learning Curve",
        "Mathematics Disorder",
        "Dyscalculia",
        "Dyscalculia, Primary",
        "Dyscalculia, Acquired",
        "Specific Learning Disorder, With Impairment in Mathematics",
        "Individuality",
        "Behavior, Child",
        "Behavior and Behavior Mechanisms",
        "Behavior",
        "Decision Making",
        "Neuronal Plasticity",
        "Cognition",
        "Cognition Disorder",
        "Cognitive Dysfunction",
        "Cognitive Change",
        "Cognitive Impairment, Mild",
        "Cognitive Developmental Delay",
        "Cognitive Orientation",
        "Cognitive Delay, Mild",
        "Cognitive Deficits, Mild",
        "Cognitive Abnormality",
        "Neuroscience"
      ],
      "interventions": [
        {
          "name": "Interventions in Mathematics and Cognitive Skills - Experimental",
          "type": "OTHER"
        },
        {
          "name": "Interventions in Mathematics and Cognitive Skills - Active Comparator",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "6 Years to 12 Years"
      },
      "enrollment_count": 180,
      "start_date": "2023-05-05",
      "completion_date": "2027-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-11",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05201534"
    },
    {
      "nct_id": "NCT03141164",
      "title": "Peripheral Vision Training Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Visual Impairment",
        "Cognitive Change"
      ],
      "interventions": [
        {
          "name": "computerized training",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "18 Years to 89 Years"
      },
      "enrollment_count": 30,
      "start_date": "2017-05-30",
      "completion_date": "2020-09-30",
      "has_results": false,
      "last_update_posted_date": "2021-06-08",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03141164"
    },
    {
      "nct_id": "NCT06840808",
      "title": "Treating Word Finding Difficulties in Traumatic Brain Injury With HD-tDCS",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Traumatic Brain Injury",
        "Cognitive Change",
        "Word Finding Difficulty",
        "Acquired Brain Injury"
      ],
      "interventions": [
        {
          "name": "Active Transcranial direct current stimulation",
          "type": "DEVICE"
        },
        {
          "name": "Sham Transcranial direct current stimulation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "The University of Texas at Dallas",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 14,
      "start_date": "2024-12-01",
      "completion_date": "2025-11-12",
      "has_results": false,
      "last_update_posted_date": "2026-02-25",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 1,
      "location_summary": "Richardson, Texas",
      "locations": [
        {
          "city": "Richardson",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06840808"
    },
    {
      "nct_id": "NCT06334354",
      "title": "A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Breast Cancer Survivors"
      ],
      "interventions": [
        {
          "name": "Assessments",
          "type": "OTHER"
        },
        {
          "name": "Assessment (Survivors Only)",
          "type": "OTHER"
        },
        {
          "name": "APOE and DNA Isolation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Memorial Sloan Kettering Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "80 Years",
        "sex": "FEMALE",
        "summary": "60 Years to 80 Years · Female only"
      },
      "enrollment_count": 420,
      "start_date": "2024-05-10",
      "completion_date": "2028-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-14",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 7,
      "location_summary": "Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more",
      "locations": [
        {
          "city": "Basking Ridge",
          "state": "New Jersey"
        },
        {
          "city": "Middletown",
          "state": "New Jersey"
        },
        {
          "city": "Montvale",
          "state": "New Jersey"
        },
        {
          "city": "Commack",
          "state": "New York"
        },
        {
          "city": "Harrison",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06334354"
    },
    {
      "nct_id": "NCT05315531",
      "title": "The Effects of Hydration on Gut Health and Thinking",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Dehydration",
        "Cognitive Change",
        "Gastrointestinal Microbiota"
      ],
      "interventions": [
        {
          "name": "Water Intake",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Illinois at Urbana-Champaign",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "19 Years to 50 Years"
      },
      "enrollment_count": 23,
      "start_date": "2021-08-23",
      "completion_date": "2022-07-29",
      "has_results": false,
      "last_update_posted_date": "2024-01-11",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 1,
      "location_summary": "Urbana, Illinois",
      "locations": [
        {
          "city": "Urbana",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05315531"
    },
    {
      "nct_id": "NCT04551937",
      "title": "Effects of Prebiotics on Cognition and Health",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Physiological Stress",
        "Cognitive Change",
        "Gastrointestinal Health"
      ],
      "interventions": [
        {
          "name": "Lactose Free 1% Milk",
          "type": "OTHER"
        },
        {
          "name": "Lactose Free 1% Milk + 10 g prebiotic",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Illinois at Urbana-Champaign",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "25 Years to 45 Years"
      },
      "enrollment_count": 24,
      "start_date": "2018-02-14",
      "completion_date": "2018-09-18",
      "has_results": false,
      "last_update_posted_date": "2020-09-16",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 1,
      "location_summary": "Urbana, Illinois",
      "locations": [
        {
          "city": "Urbana",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04551937"
    },
    {
      "nct_id": "NCT01703702",
      "title": "Effectiveness of Florbetapir (18F) PET Imaging in Changing Patient Management and the Relationship Between Scan Status and Cognitive Decline",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Alzheimer's Disease"
      ],
      "interventions": [
        {
          "name": "florbetapir (18F)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Avid Radiopharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "50 Years to 90 Years"
      },
      "enrollment_count": 641,
      "start_date": "2012-10",
      "completion_date": "2015-04",
      "has_results": true,
      "last_update_posted_date": "2016-08-17",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 21,
      "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Sun City, Arizona + 15 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Sun City",
          "state": "Arizona"
        },
        {
          "city": "Clearwater",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01703702"
    },
    {
      "nct_id": "NCT07147894",
      "title": "Executive Function Training for Children and Adolescents",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognitive Change"
      ],
      "interventions": [
        {
          "name": "Nongamified N-back training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Gamified N-back training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Multiple Domain Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Coaching Session",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Northeastern University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "12 Years to 17 Years"
      },
      "enrollment_count": 780,
      "start_date": "2025-12-14",
      "completion_date": "2028-06-30",
      "has_results": false,
      "last_update_posted_date": "2025-12-23",
      "last_synced_at": "2026-10-23T00:00:39.406Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07147894"
    }
  ]
}