{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cognitive+Function%2C+Preclinical",
    "query": {
      "condition": "Cognitive Function, Preclinical"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 21,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cognitive+Function%2C+Preclinical&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-07-24T03:49:43.482Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07516119",
      "title": "Predicting Pre-dementia",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mild Cognitive Impairment (MCI)",
        "Alzheimer Dementia (AD)",
        "Alzheimer Disease (AD)",
        "APOE-4 Positive"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Prevention Research Consortium Corp.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "55 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "55 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2026-04-15",
      "completion_date": "2029-04-15",
      "has_results": false,
      "last_update_posted_date": "2026-04-07",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07516119"
    },
    {
      "nct_id": "NCT04928976",
      "title": "Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease",
        "Preclinical Alzheimer's Disease",
        "Prodromal Alzheimer's Disease",
        "Alzheimer's Disease (Incl Subtypes)",
        "Mild Cognitive Impairment"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Novoic Limited",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "50 Years to 85 Years"
      },
      "enrollment_count": 67,
      "start_date": "2021-01-22",
      "completion_date": "2021-07-30",
      "has_results": false,
      "last_update_posted_date": "2021-09-05",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 1,
      "location_summary": "Santa Ana, California",
      "locations": [
        {
          "city": "Santa Ana",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04928976"
    },
    {
      "nct_id": "NCT02719327",
      "title": "Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Alzheimer's Disease"
      ],
      "interventions": [
        {
          "name": "icosapent ethyl (IPE)",
          "type": "DRUG"
        },
        {
          "name": "gel cap placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "VA Office of Research and Development",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "50 Years to 75 Years"
      },
      "enrollment_count": 131,
      "start_date": "2017-06-08",
      "completion_date": "2023-09-29",
      "has_results": true,
      "last_update_posted_date": "2024-11-26",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02719327"
    },
    {
      "nct_id": "NCT01592552",
      "title": "A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer's Disease",
        "Multiple Sclerosis",
        "Parkinson's Disease",
        "Huntington's Disease",
        "Amyotrophic Lateral Sclerosis (ALS)"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Sanguine Biosciences",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 20,
      "start_date": "2011-11",
      "completion_date": "2015-03",
      "has_results": false,
      "last_update_posted_date": "2023-11-22",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 1,
      "location_summary": "Sherman Oaks, California",
      "locations": [
        {
          "city": "Sherman Oaks",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01592552"
    },
    {
      "nct_id": "NCT03663387",
      "title": "PET Measures of CSF Clearance in Preclinical Alzheimer's Disease",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Mild Cognitive Impairment"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Weill Medical College of Cornell University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "20 Years to 100 Years"
      },
      "enrollment_count": 116,
      "start_date": "2018-07-30",
      "completion_date": "2022-08-31",
      "has_results": false,
      "last_update_posted_date": "2022-10-20",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03663387"
    },
    {
      "nct_id": "NCT02565511",
      "title": "A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Alzheimers Disease"
      ],
      "interventions": [
        {
          "name": "CAD106 Immunotherapy",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Placebo to CAD106",
          "type": "OTHER"
        },
        {
          "name": "CNP520",
          "type": "DRUG"
        },
        {
          "name": "Placebo to CNP520",
          "type": "OTHER"
        },
        {
          "name": "Alum",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Novartis Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "60 Years to 75 Years"
      },
      "enrollment_count": 480,
      "start_date": "2015-11-30",
      "completion_date": "2020-04-30",
      "has_results": true,
      "last_update_posted_date": "2021-07-08",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 78,
      "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Sun City, Arizona + 67 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Sun City",
          "state": "Arizona"
        },
        {
          "city": "Costa Mesa",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02565511"
    },
    {
      "nct_id": "NCT03131453",
      "title": "A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Alzheimers Disease"
      ],
      "interventions": [
        {
          "name": "CNP520 50mg",
          "type": "DRUG"
        },
        {
          "name": "CNP520 15mg",
          "type": "DRUG"
        },
        {
          "name": "Matching placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Novartis Pharmaceuticals",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "60 Years to 75 Years"
      },
      "enrollment_count": 1145,
      "start_date": "2017-08-03",
      "completion_date": "2020-03-26",
      "has_results": true,
      "last_update_posted_date": "2021-08-05",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 95,
      "location_summary": "Phoenix, Arizona • Sun City, Arizona • Tucson, Arizona + 83 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Sun City",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Costa Mesa",
          "state": "California"
        },
        {
          "city": "Irvine",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03131453"
    },
    {
      "nct_id": "NCT02045056",
      "title": "Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Preclinical Alzheimer's Disease"
      ],
      "interventions": [
        {
          "name": "Gemfibrozil",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Gregory Jicha, 323-5550",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "65 Years to 90 Years"
      },
      "enrollment_count": 72,
      "start_date": "2014-05",
      "completion_date": "2019-06",
      "has_results": false,
      "last_update_posted_date": "2019-10-08",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02045056"
    },
    {
      "nct_id": "NCT03644043",
      "title": "Evidence Amyloid Scan EEG Study",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Alzheimer Disease",
        "Dementia Frontal",
        "Mild Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "EEG scan",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Metabolic Therapy Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 2000,
      "start_date": "2018-07-20",
      "completion_date": "2020-11-30",
      "has_results": false,
      "last_update_posted_date": "2018-08-23",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03644043"
    },
    {
      "nct_id": "NCT03197038",
      "title": "Exercise Training and Cognitive Function in Kidney Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cognitive Function, Preclinical",
        "Chronic Kidney Diseases",
        "Older Adults"
      ],
      "interventions": [
        {
          "name": "Partially supervised home-based walking exercise",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Control",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Illinois at Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "60 Years to 80 Years"
      },
      "enrollment_count": 39,
      "start_date": "2017-09-01",
      "completion_date": "2019-12-18",
      "has_results": true,
      "last_update_posted_date": "2021-07-02",
      "last_synced_at": "2026-07-24T03:49:43.482Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03197038"
    }
  ]
}