{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cognitive+Impairment",
    "query": {
      "condition": "Cognitive Impairment"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 1847,
    "total_pages": 185,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Cognitive+Impairment&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-06-07T11:57:57.212Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05399888",
      "title": "A Study to Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Mild Cognitive Impairment Due to Alzheimer's Disease",
        "Alzheimer's Disease Dementia"
      ],
      "interventions": [
        {
          "name": "BIIB080",
          "type": "DRUG"
        },
        {
          "name": "BIIB080-matching placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Biogen",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "50 Years to 80 Years"
      },
      "enrollment_count": 416,
      "start_date": "2022-08-24",
      "completion_date": "2028-06-06",
      "has_results": false,
      "last_update_posted_date": "2026-06-05",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 36,
      "location_summary": "Phoenix, Arizona • Scottsdale, Arizona • Sun City, Arizona + 30 more",
      "locations": [
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Sun City",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05399888"
    },
    {
      "nct_id": "NCT03717922",
      "title": "Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Brain Diseases",
        "Memory Disorders",
        "Learning Disabilities",
        "Cognitive Impairment"
      ],
      "interventions": [
        {
          "name": "Low Intensity Focused Ultrasound Pulsation to Amygdala",
          "type": "DEVICE"
        },
        {
          "name": "Low Intensity Focused Ultrasound Pulsation to Entorhinal Cortex",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": "90 Years",
        "sex": "ALL",
        "summary": "35 Years to 90 Years"
      },
      "enrollment_count": 21,
      "start_date": "2019-06-28",
      "completion_date": "2022-12-20",
      "has_results": true,
      "last_update_posted_date": "2024-03-20",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03717922"
    },
    {
      "nct_id": "NCT06728774",
      "title": "Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Major Depressive Disorder (MDD)",
        "Cognitive Dysfunction"
      ],
      "interventions": [
        {
          "name": "Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Goal-focused Supportive Contact",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Portland VA Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2025-05-01",
      "completion_date": "2026-06",
      "has_results": false,
      "last_update_posted_date": "2025-06-06",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 1,
      "location_summary": "Portland, Oregon",
      "locations": [
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06728774"
    },
    {
      "nct_id": "NCT06318390",
      "title": "The Impact of KETO5 XOGenius Beverage on Markers of Physiological and Neurocognitive Health",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiovascular Diseases",
        "Hypertension",
        "Cognitive Decline",
        "Diet",
        "Healthy"
      ],
      "interventions": [
        {
          "name": "XO Genius",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "The University of Texas at Arlington",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 6,
      "start_date": "2023-08-01",
      "completion_date": "2025-05-31",
      "has_results": false,
      "last_update_posted_date": "2025-09-26",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 1,
      "location_summary": "Arlington, Texas",
      "locations": [
        {
          "city": "Arlington",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06318390"
    },
    {
      "nct_id": "NCT03889327",
      "title": "Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Multiple Sclerosis"
      ],
      "interventions": [
        {
          "name": "Neuropsychological Feedback & Psychoeducation (Cognition)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Psychoeducation (Health)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Missouri, Kansas City",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 51,
      "start_date": "2018-03-26",
      "completion_date": "2019-09-01",
      "has_results": false,
      "last_update_posted_date": "2024-12-06",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 1,
      "location_summary": "Kansas City, Kansas",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Kansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03889327"
    },
    {
      "nct_id": "NCT04212442",
      "title": "Improving Aging in Place in Subsidized Housing",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Physical Disability",
        "Cognitive Impairment",
        "Physical Activity"
      ],
      "interventions": [
        {
          "name": "Independent Living Program for Affordable Housing.",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "62 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "62 Years and older"
      },
      "enrollment_count": 75,
      "start_date": "2020-01-13",
      "completion_date": "2023-03-02",
      "has_results": true,
      "last_update_posted_date": "2024-11-15",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 13,
      "location_summary": "Camden, New Jersey • Cape May, New Jersey • Pennsauken, New Jersey + 1 more",
      "locations": [
        {
          "city": "Camden",
          "state": "New Jersey"
        },
        {
          "city": "Cape May",
          "state": "New Jersey"
        },
        {
          "city": "Cape May",
          "state": "New Jersey"
        },
        {
          "city": "Pennsauken",
          "state": "New Jersey"
        },
        {
          "city": "Pennsauken",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04212442"
    },
    {
      "nct_id": "NCT05935241",
      "title": "mPATH for Low-income Older Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sedentary Time",
        "Insomnia",
        "Cognitive Decline"
      ],
      "interventions": [
        {
          "name": "mPATH",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Attention Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 176,
      "start_date": "2024-05-30",
      "completion_date": "2029-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-13",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05935241"
    },
    {
      "nct_id": "NCT01600859",
      "title": "Evaluation of E2609 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (Study: E2609-A001-101 Amendment 02)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Alzheimer's Disease"
      ],
      "interventions": [
        {
          "name": "E2609",
          "type": "DRUG"
        },
        {
          "name": "Placebo for E2609",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Eisai Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "50 Years to 85 Years"
      },
      "enrollment_count": 65,
      "start_date": "2012-07",
      "completion_date": "2013-10",
      "has_results": false,
      "last_update_posted_date": "2016-12-30",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 2,
      "location_summary": "Glendale, California • Baltimore, Maryland",
      "locations": [
        {
          "city": "Glendale",
          "state": "California"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01600859"
    },
    {
      "nct_id": "NCT04469959",
      "title": "Dopaminergic Dysfunction in Late-Life Depression",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Late Life Depression",
        "Cognitive Decline",
        "Depressive Disorder, Treatment-Resistant",
        "Levodopa",
        "Gait Impairment"
      ],
      "interventions": [
        {
          "name": "L-Dopa",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 79,
      "start_date": "2021-02-15",
      "completion_date": "2026-04-29",
      "has_results": false,
      "last_update_posted_date": "2026-05-28",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 2,
      "location_summary": "Pittsburgh, Pennsylvania • Nashville, Tennessee",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04469959"
    },
    {
      "nct_id": "NCT02411461",
      "title": "Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Pseudohypoparathyroidism",
        "Albright Hereditary Osteodystrophy"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "6 Years to 18 Years"
      },
      "enrollment_count": 39,
      "start_date": "2014-12-01",
      "completion_date": "2017-01",
      "has_results": true,
      "last_update_posted_date": "2019-11-13",
      "last_synced_at": "2026-06-07T11:57:57.212Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02411461"
    }
  ]
}