{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Comparative+Effectiveness+Research&page=2",
    "query": {
      "condition": "Comparative Effectiveness Research",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Comparative+Effectiveness+Research&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-10T14:06:52.469Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03486028",
      "title": "Patient Centered Assessment and Substance Use Disorder Treatment Study (PCAST)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Substance Use Disorders"
      ],
      "interventions": [
        {
          "name": "Adherence to ASAM protocols",
          "type": "OTHER"
        },
        {
          "name": "Non-adherence to ASAM protocols",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "RTI International",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Years and older"
      },
      "enrollment_count": 991,
      "start_date": "2018-07-31",
      "completion_date": "2019-10-27",
      "has_results": false,
      "last_update_posted_date": "2019-11-26",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 1,
      "location_summary": "Research Triangle Park, North Carolina",
      "locations": [
        {
          "city": "Research Triangle Park",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03486028"
    },
    {
      "nct_id": "NCT05531591",
      "title": "RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Depression",
        "Dementia",
        "Mild Cognitive Impairment",
        "Treatment Resistant Depression",
        "Major Depressive Disorder",
        "Treatment-Refractory Depression",
        "Late Life Depression",
        "Geriatric Depression"
      ],
      "interventions": [
        {
          "name": "Aripiprazole Augmentation",
          "type": "DRUG"
        },
        {
          "name": "Bupropion Augmentation",
          "type": "DRUG"
        },
        {
          "name": "Switch to bupropion",
          "type": "DRUG"
        },
        {
          "name": "Lithium Augmentation",
          "type": "DRUG"
        },
        {
          "name": "Switch to nortriptyline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Centre for Addiction and Mental Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "60 Years and older"
      },
      "enrollment_count": 87,
      "start_date": "2019-08-01",
      "completion_date": "2024-07-31",
      "has_results": false,
      "last_update_posted_date": "2024-11-25",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 3,
      "location_summary": "Los Angeles, California • St Louis, Missouri • New York, New York",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05531591"
    },
    {
      "nct_id": "NCT01142882",
      "title": "Comparative Effectiveness of Web-based Versus Traditional Adolescent HIV Prevention",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "HIV Infections",
        "Hepatitis",
        "Sexually Transmitted Infections"
      ],
      "interventions": [
        {
          "name": "Traditional Prevention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Web-based Prevention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "National Development and Research Institutes, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "12 Years to 18 Years"
      },
      "enrollment_count": 120,
      "start_date": "2010-02",
      "completion_date": "2011-08",
      "has_results": false,
      "last_update_posted_date": "2011-07-20",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 3,
      "location_summary": "Brooklyn, New York • Jamaica, New York • The Bronx, New York",
      "locations": [
        {
          "city": "Brooklyn",
          "state": "New York"
        },
        {
          "city": "Jamaica",
          "state": "New York"
        },
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01142882"
    },
    {
      "nct_id": "NCT02119182",
      "title": "Transforming Research and Clinical Knowledge in Traumatic Brain Injury",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Traumatic Brain Injury"
      ],
      "interventions": [
        {
          "name": "In-Person Outcome Assessment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Phone Outcome Assessment",
          "type": "BEHAVIORAL"
        },
        {
          "name": "3T Magnetic Resonance Imaging (MRI)",
          "type": "PROCEDURE"
        },
        {
          "name": "Blood Draw for Plasma, DNA, Serum, RNA",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "PROCEDURE"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Year",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "1 Year to 100 Years"
      },
      "enrollment_count": 2996,
      "start_date": "2014-03-02",
      "completion_date": "2020-08-31",
      "has_results": false,
      "last_update_posted_date": "2020-09-16",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 23,
      "location_summary": "San Francisco, California • Denver, Colorado • Englewood, Colorado + 17 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Englewood",
          "state": "Colorado"
        },
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02119182"
    },
    {
      "nct_id": "NCT05452642",
      "title": "The Supporting Understanding of PCOS Education and Research (SUPER) Study",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Polycystic Ovary"
      ],
      "interventions": [
        {
          "name": "DASH diet",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Very low-carbohydrate diet",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "21 Years to 45 Years · Female only"
      },
      "enrollment_count": 223,
      "start_date": "2022-08-15",
      "completion_date": "2026-07-15",
      "has_results": false,
      "last_update_posted_date": "2025-12-15",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05452642"
    },
    {
      "nct_id": "NCT02977299",
      "title": "Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Treatment Resistant Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Aripiprazole",
          "type": "DRUG"
        },
        {
          "name": "Repetitive transcranial magnetic stimulation (rTMS)",
          "type": "DEVICE"
        },
        {
          "name": "Venlafaxine XR",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 278,
      "start_date": "2017-05-01",
      "completion_date": "2022-04-24",
      "has_results": false,
      "last_update_posted_date": "2022-04-27",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 11,
      "location_summary": "Birmingham, Alabama • Los Angeles, California • Stanford, California + 8 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Tampa",
          "state": "Florida"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02977299"
    },
    {
      "nct_id": "NCT02133391",
      "title": "Accountable Care Organizations/ Public Health Collaborative",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Immunization Reminder System"
      ],
      "interventions": [
        {
          "name": "Centralized Reminder/Recall (R/R)",
          "type": "OTHER"
        },
        {
          "name": "Practice-based Reminder/Recall",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "19 Months",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "19 Months and older"
      },
      "enrollment_count": 78354,
      "start_date": "2015-02-18",
      "completion_date": "2017-07-14",
      "has_results": false,
      "last_update_posted_date": "2017-09-29",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 1,
      "location_summary": "Aurora, Colorado",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02133391"
    },
    {
      "nct_id": "NCT01114685",
      "title": "A Comparison of Changes in Bone Density With the Same Bone-health Plan, But With Different Bone-health Supplements",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteopenia"
      ],
      "interventions": [
        {
          "name": "AlgaeCal-1",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "AlgaeCal-2",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Integrative Health Technologies, Inc.",
      "sponsor_class": "NETWORK",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 354,
      "start_date": "2006-06",
      "completion_date": "2010-03",
      "has_results": false,
      "last_update_posted_date": "2010-05-03",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01114685"
    },
    {
      "nct_id": "NCT04441034",
      "title": "Stanford Pragmatic Effectiveness Comparison",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Anti-convulsant medications",
          "type": "DRUG"
        },
        {
          "name": "Anti-depressant medications",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 450,
      "start_date": "2022-04-12",
      "completion_date": "2027-04-30",
      "has_results": false,
      "last_update_posted_date": "2026-05-22",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 1,
      "location_summary": "Redwood City, California",
      "locations": [
        {
          "city": "Redwood City",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04441034"
    },
    {
      "nct_id": "NCT06023459",
      "title": "Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Opioid-Related Disorders",
        "Substance-Related Disorders",
        "Narcotic-Related Disorders"
      ],
      "interventions": [
        {
          "name": "Injectable extended-release buprenorphine",
          "type": "DRUG"
        },
        {
          "name": "Sublingual buprenorphine-naloxone",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yih-Ing Hser",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 140,
      "start_date": "2024-10-14",
      "completion_date": "2026-01-14",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-06-10T14:06:52.469Z",
      "location_count": 7,
      "location_summary": "El Dorado, Arkansas • Garberville, California • Gibson City, Illinois + 4 more",
      "locations": [
        {
          "city": "El Dorado",
          "state": "Arkansas"
        },
        {
          "city": "Garberville",
          "state": "California"
        },
        {
          "city": "Gibson City",
          "state": "Illinois"
        },
        {
          "city": "Belfast",
          "state": "Maine"
        },
        {
          "city": "Scappoose",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06023459"
    }
  ]
}