{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Corneal+Crosslinking&page=2",
    "query": {
      "condition": "Corneal Crosslinking",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?condition=Corneal+Crosslinking&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-06-11T03:11:15.368Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04897503",
      "title": "Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Keratoconus",
        "Corneal Ectasia"
      ],
      "interventions": [
        {
          "name": "Riboflavin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cornea and Laser Eye Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 170,
      "start_date": "2021-04-16",
      "completion_date": "2025-12",
      "has_results": false,
      "last_update_posted_date": "2023-01-04",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 1,
      "location_summary": "Teaneck, New Jersey",
      "locations": [
        {
          "city": "Teaneck",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04897503"
    },
    {
      "nct_id": "NCT04584125",
      "title": "A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Keratoconus"
      ],
      "interventions": [
        {
          "name": "Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light",
          "type": "DRUG"
        },
        {
          "name": "Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Joseph B. Ciolino, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 216,
      "start_date": "2027-01-01",
      "completion_date": "2028-11-30",
      "has_results": false,
      "last_update_posted_date": "2026-04-08",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04584125"
    },
    {
      "nct_id": "NCT07135167",
      "title": "Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Down Syndrome (DS)",
        "Keratoconus",
        "Pellucid Marginal Degeneration",
        "Forme Fruste Keratoconus (FFK)"
      ],
      "interventions": [
        {
          "name": "Epi-ON corneal cross-linking (CXL)",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Woolfson Eye Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "8 Years and older"
      },
      "enrollment_count": 225,
      "start_date": "2025-08-01",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-02-02",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 12,
      "location_summary": "Atlanta, Georgia • Canton, Georgia • Cumming, Georgia + 8 more",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Canton",
          "state": "Georgia"
        },
        {
          "city": "Cumming",
          "state": "Georgia"
        },
        {
          "city": "Douglasville",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07135167"
    },
    {
      "nct_id": "NCT01189864",
      "title": "Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Keratoconus",
        "Ectasia",
        "Degeneration"
      ],
      "interventions": [
        {
          "name": "Ciprofloxicin or Vigamox or other.",
          "type": "DRUG"
        },
        {
          "name": "Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc)",
          "type": "DRUG"
        },
        {
          "name": "Steroid (FML, Pred Forte, Flarex, etc.)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cxlusa",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 3493,
      "start_date": "2010-02-01",
      "completion_date": "2017-02-03",
      "has_results": false,
      "last_update_posted_date": "2018-10-12",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 16,
      "location_summary": "Scottsdale, Arizona • Laguna Hills, California • San Diego, California + 13 more",
      "locations": [
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Laguna Hills",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "West Hills",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01189864"
    },
    {
      "nct_id": "NCT01956474",
      "title": "CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Keratoconus"
      ],
      "interventions": [
        {
          "name": "Theralight crosslinking and Riboflavin",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Cxlusa",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "8 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "8 Years and older"
      },
      "enrollment_count": 1324,
      "start_date": "2013-01",
      "completion_date": "2017-02-03",
      "has_results": false,
      "last_update_posted_date": "2018-10-12",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 6,
      "location_summary": "Miami, Florida • Atlanta, Georgia • Rockville, Maryland + 3 more",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Rockville",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Brecksville",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01956474"
    },
    {
      "nct_id": "NCT03938883",
      "title": "Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy (\"PRK\")",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ophthalmology",
        "Photorefractive Keratectomy (\"PRK\")",
        "Laser Assisted Surgery",
        "Refractive Surgery"
      ],
      "interventions": [
        {
          "name": "Ocular Bandage Gel (OBG)",
          "type": "DEVICE"
        },
        {
          "name": "Bandage Contact Lens (BCL)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Eyegate Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "22 Years to 50 Years"
      },
      "enrollment_count": 250,
      "start_date": "2019-06-25",
      "completion_date": "2019-10-10",
      "has_results": false,
      "last_update_posted_date": "2019-12-13",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 1,
      "location_summary": "Sioux Falls, South Dakota",
      "locations": [
        {
          "city": "Sioux Falls",
          "state": "South Dakota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03938883"
    },
    {
      "nct_id": "NCT03163641",
      "title": "Safety and Effectiveness of OBG vs.a Bandage Contact Lens for Large Corneal Epithelial Defects in Patients Post-PRK.",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Corneal Epithelial Wound"
      ],
      "interventions": [
        {
          "name": "Acuvue Oasys",
          "type": "DEVICE"
        },
        {
          "name": "Ocular Bandage Gel",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Eyegate Pharmaceuticals, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "22 Years to 50 Years"
      },
      "enrollment_count": 45,
      "start_date": "2018-08-05",
      "completion_date": "2018-11-08",
      "has_results": false,
      "last_update_posted_date": "2020-12-17",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03163641"
    },
    {
      "nct_id": "NCT04240457",
      "title": "Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Keratoconus",
        "Cornea Ectasia"
      ],
      "interventions": [
        {
          "name": "Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.",
          "type": "COMBINATION_PRODUCT"
        }
      ],
      "intervention_types": [
        "COMBINATION_PRODUCT"
      ],
      "sponsor": "Arbor Center for Eye Care",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "12 Years to 60 Years"
      },
      "enrollment_count": 11,
      "start_date": "2020-07-08",
      "completion_date": "2023-02-18",
      "has_results": true,
      "last_update_posted_date": "2024-12-12",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 1,
      "location_summary": "Orland Park, Illinois",
      "locations": [
        {
          "city": "Orland Park",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04240457"
    },
    {
      "nct_id": "NCT06235567",
      "title": "Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Keratoconus"
      ],
      "interventions": [
        {
          "name": "Dextenza 0.4Mg Ophthalmic Insert",
          "type": "DRUG"
        },
        {
          "name": "topical prednisolone acetate 1% (PredForte) eye drops",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Maanasa Indaram, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "64 Years",
        "sex": "ALL",
        "summary": "13 Years to 64 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-04-11",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-03-24",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 3,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06235567"
    },
    {
      "nct_id": "NCT05423041",
      "title": "A Prospective Clinical Trial Designed to Evaluate the Repeatability and Reproducibility of the Intelon BOSS(tm) System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Corneal Transplant",
        "Corneal Crosslinking",
        "Healthy Eyes"
      ],
      "interventions": [
        {
          "name": "BOSS Imaging",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Intelon Optics, Inc",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 34,
      "start_date": "2022-05-14",
      "completion_date": "2022-09-13",
      "has_results": false,
      "last_update_posted_date": "2025-05-04",
      "last_synced_at": "2026-06-11T03:11:15.368Z",
      "location_count": 1,
      "location_summary": "Fayetteville, Arkansas",
      "locations": [
        {
          "city": "Fayetteville",
          "state": "Arkansas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05423041"
    }
  ]
}